Recombinant Mouse Netrin-1 Protein

This product or the use of this product is covered by U.S. Patents owned by The Regents of the University of California. This product is for research use only and is not to be used for commercial purposes. Use of this product to produce products for sale or for diagnostic, therapeutic or drug discovery purposes is prohibited. In order to obtain a license to use this product for such purposes, contact The Regents of the University of California.

U.S. Patent # 5,565,331, 6,096,866, 6,017,714, 6,309,638, 6,670,451, and other U.S. and international patents pending.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Mouse Netrin-1 is a member of the laminin-related family of axon-guidance molecules, collectively referred to as Netrins (netr is Sanskrit for “one who guides”). The molecule’s cDNA encodes a 603 amino acid (aa) protein precursor that has structural similarity to the N-terminal gamma ‑chain of laminin. It contains a globular domain, three EGF repeats, and a C-terminal heparin-binding domain. Mouse Netrin-1 shares 52% aa identity with mouse Netrin-3, and 98% and 87% aa identity with human and chicken Netrin-1, respectively. Cells reported to express Netrin-1 in the embryo include cells of the floor plate, ventricular zone of the spinal cord, the brain, the ganglionic eminence, and parts of the diencephalon. Netrins were first identified for promoting the outgrowth of commissural axons and are also involved in helping migrating cells and axonal growth cones navigate to their targets. Netrins can provide both attractive and repulsive cues to neurons, depending on the receptors present and cellular context. In the adult, Netrin-1 is likely involved in axon regeneration in peripheral nerves. Netrin-1 has also been shown to be expressed outside of the nervous system and to be involved in development of such tissues as the pancreas, lung, bowel, bone and mammary gland. In non-neural organogenesis, Netrin‑1 provides an adhesive rather than guidance function. The DCC (deleted in colorectal carcinoma), Neogenin, the UNC5 family of receptors, and the adenosine A2b receptors are proposed to be functional receptors for Netrin-1 (1‑7).

We have publications tested in 7 confirmed species: Human, Mouse, Rat, African Green Monkey, Bovine, Chicken, Primate - Macaca mulatta (Rhesus Macaque).

We have publications tested in 3 applications: Bioassay, Cell Culture, In Vivo.

Showing Publications 1 - 10 of 40. Show All 40 Publications. Collapse Publications.

Publications using 1109-N1	Applications	Species
Alvarez, S;Gupta, S;Honeychurch, K;Mercado-Ayon, Y;Kawaguchi, R;Butler, SJ; Netrin1 patterns the dorsal spinal cord through modulation of Bmp signaling bioRxiv : the preprint server for biology 2023-11-04 [PMID: 37961605] (Bioassay, African Green Monkey)	Bioassay	African Green Monkey
Schlienger, S;Yam, PT;Balekoglu, N;Ducuing, H;Michaud, JF;Makihara, S;Kramer, DK;Chen, B;Fasano, A;Berardelli, A;Hamdan, FF;Rouleau, GA;Srour, M;Charron, F; Genetics of mirror movements identifies a multifunctional complex required for Netrin-1 guidance and lateralization of motor control Science advances 2023-05-12 [PMID: 37172092] (Bioassay, Rat)	Bioassay	Rat
P Ramalingam, MC Gutkin, MG Poulos, T Tillery, C Doughty, A Winiarski, AG Freire, S Rafii, D Redmond, JM Butler Restoring bone marrow niche function rejuvenates aged hematopoietic stem cells by reactivating the DNA Damage Response Nature Communications, 2023-04-10;14(1):2018. 2023-04-10 [PMID: 37037837] (Bioassay, Mouse)	Bioassay	Mouse
X Xia, Z Mao, W Wang, J Ma, J Tian, S Wang, K Yin Netrin-1 promotes the immunosuppressive activity of MDSCs in colorectal cancer Cancer Immunology Research, 2023-05-03;0(0):. 2023-05-03 [PMID: 36812256] (Bioassay, Mouse)	Bioassay	Mouse
Y Zang, K Chaudhari, GJ Bashaw Tace/ADAM17 is a bi-directional regulator of axon guidance that coordinates distinct Frazzled and Dcc receptor signaling outputs Cell Reports, 2022-12-06;41(10):111785. 2022-12-06 [PMID: 36476876] (Bioassay, Mouse)	Bioassay	Mouse
ES Chan, Y Ge, YW So, YF Bai, L Liu, YT Wang Allosteric potentiation of GABAA receptor single-channel conductance by netrin-1 during neuronal-excitation-induced inhibitory synaptic homeostasis Cell Reports, 2022-11-01;41(5):111584. 2022-11-01 [PMID: 36323250] (Bioassay, Mouse)	Bioassay	Mouse
H Wei, L Ailanen, M Morales, A Koivisto, A Pertovaara Spinal TRPA1 Contributes to the Mechanical Hypersensitivity Effect Induced by Netrin-1 International Journal of Molecular Sciences, 2022-06-14;23(12):. 2022-06-14 [PMID: 35743067] (Bioassay, Mouse)	Bioassay	Mouse
V Barroca, C Racine, L Pays, P Fouchet, M Coureuil, I Allemand The netrin-1 receptor UNC5C contributes to the homeostasis of undifferentiated spermatogonia in adult mice Stem Cell Research, 2022-02-25;60(0):102723. 2022-02-25 [PMID: 35247845] (Bioassay, Mouse)	Bioassay	Mouse
K Boyé, LH Geraldo, J Furtado, L Pibouin-Fr, M Poulet, D Kim, B Nelson, Y Xu, L Jacob, N Maissa, D Agalliu, L Claesson-W, SL Ackerman, A Eichmann Endothelial Unc5B controls blood-brain barrier integrity Nature Communications, 2022-03-04;13(1):1169. 2022-03-04 [PMID: 35246514] (Bioassay, Mouse)	Bioassay	Mouse
D Pradella, G Deflorian, A Pezzotta, A Di Matteo, E Belloni, D Campolungo, A Paradisi, M Bugatti, W Vermi, M Campioni, A Chiapparin, L Scietti, F Forneris, C Giampietro, N Volf, M Rehman, S Zacchigna, MP Paronetto, A Pistocchi, A Eichmann, P Mehlen, C Ghigna A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis Nature Communications, 2021-08-11;12(1):4872. 2021-08-11 [PMID: 34381052] (Bioassay, Human)	Bioassay	Human
G Chen, SS Kang, Z Wang, EH Ahn, Y Xia, X Liu, IM Sandoval, FP Manfredsso, Z Zhang, K Ye Netrin-1 receptor UNC5C cleavage by active &delta-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologies Science Advances, 2021-04-16;7(16):. 2021-04-16 [PMID: 33863723] (Bioassay, Rat)	Bioassay	Rat
T Shigeoka, M Koppers, HH Wong, JQ Lin, R Cagnetta, A Dwivedy, J de Freitas, FW van Tartwi, F Ströhl, JM Cioni, J Schaeffer, M Carrington, CF Kaminski, H Jung, WA Harris, CE Holt On-Site Ribosome Remodeling by Locally Synthesized Ribosomal Proteins in Axons Cell Rep, 2019-12-10;29(11):3605-3619.e10. 2019-12-10 [PMID: 31825839] (Cell Culture, Mouse)	Cell Culture	Mouse
A Pignata, H Ducuing, L Boubakar, T Gardette, K Kindbeiter, M Bozon, S Tauszig-De, J Falk, O Thoumine, V Castellani A Spatiotemporal Sequence of Sensitization to Slits and Semaphorins Orchestrates Commissural Axon Navigation Cell Rep, 2019-10-08;29(2):347-362.e5. 2019-10-08 [PMID: 31597096] (Bioassay, Chicken)	Bioassay	Chicken
Q Shao, T Yang, H Huang, T Majumder, BA Khot, MM Khouzani, F Alarmanazi, YK Gore, G Liu Disease-associated mutations in human TUBB3 disturb netrin repulsive signaling PLoS ONE, 2019-06-21;14(6):e0218811. 2019-06-21 [PMID: 31226147] (In Vivo, Mouse)	In Vivo	Mouse
M Zhuang, X Li, J Zhu, J Zhang, F Niu, F Liang, M Chen, D Li, P Han, SJ Ji The m6A reader YTHDF1 regulates axon guidance through translational control of Robo3.1 expression Nucleic Acids Res., 2019-05-21;0(0):. 2019-05-21 [PMID: 30843071] (Bioassay, Mouse)	Bioassay	Mouse
X He, Y Liu, X Lin, F Yuan, D Long, Z Zhang, Y Wang, A Xuan, GY Yang Netrin-1 attenuates brain injury after middle cerebral artery occlusion via downregulation of astrocyte activation in mice J Neuroinflammation, 2018-09-18;15(1):268. 2018-09-18 [PMID: 30227858] (In Vivo, Mouse)	In Vivo	Mouse
Y Zhang, P Chen, G Di, X Qi, Q Zhou, H Gao Netrin-1 promotes diabetic corneal wound healing through molecular mechanisms mediated via the adenosine 2B receptor Sci Rep, 2018-04-16;8(1):5994. 2018-04-16 [PMID: 29662125] (Mouse)		Mouse
T Sato, S Kokabu, Y Enoki, N Hayashi, M Matsumoto, M Nakahira, M Sugasawa, T Yoda Functional Roles of Netrin-1 in Osteoblast Differentiation In Vivo, 2017-05-01;31(3):321-328. 2017-05-01 [PMID: 28438858] (Bioassay, Mouse)	Bioassay	Mouse
K Yamahara, T Nakagawa, J Ito, K Kinoshita, K Omori, N Yamamoto Netrin 1 mediates protective effects exerted by insulin-like growth factor 1 on cochlear hair cells Neuropharmacology, 2017-04-01;119(0):26-39. 2017-04-01 [PMID: 28373074] (Bioassay, Mouse)	Bioassay	Mouse
KA Glendining, D Markie, RJ Gardner, EA Franz, SP Robertson, CL Jasoni A novel role for the DNA repair gene Rad51 in Netrin-1 signalling Sci Rep, 2017-01-06;7(0):39823. 2017-01-06 [PMID: 28057929] (Bioassay, Mouse)	Bioassay	Mouse
Y Hashimoto, Y Toyama, S Kusakari, M Nawa, M Matsuoka An Alzheimer's disease-linked rare mutation potentiates netrin receptor uncoordinated-5C-induced signaling that merges with amyloid ? precursor protein signaling J Biol Chem, 2016-04-11;0(0):. 2016-04-11 [PMID: 27068745] (Bioassay, Human)	Bioassay	Human
Ros O, Cotrufo T, Martinez-Marmol R, Soriano E Regulation of patterned dynamics of local exocytosis in growth cones by netrin-1. J Neurosci, 2015-04-01;35(13):5156-70. 2015-04-01 [PMID: 25834042] (Bioassay, Rat)	Bioassay	Rat
Deming P, Campbell S, Stone J, Rivard R, Mercier A, Howe A Anchoring of protein kinase A by ERM (ezrin-radixin-moesin) proteins is required for proper netrin signaling through DCC (deleted in colorectal cancer). J Biol Chem, 2015-01-09;290(9):5783-96. 2015-01-09 [PMID: 25575591] (Bioassay, Mouse)	Bioassay	Mouse
Mediero A, Ramkhelawon B, Perez-Aso M, Moore K, Cronstein B Netrin-1 is a critical autocrine/paracrine factor for osteoclast differentiation. J Bone Miner Res, 2015-05-01;30(5):837-54. 2015-05-01 [PMID: 25483983] (Bioassay, Mouse)	Bioassay	Mouse
O'Leary C, Bradford D, Chen M, White A, Blackmore D, Cooper H The Netrin/RGM receptor, Neogenin, controls adult neurogenesis by promoting neuroblast migration and cell cycle exit. Stem Cells, 2015-02-01;33(2):503-14. 2015-02-01 [PMID: 25308084] (Bioassay, Mouse)	Bioassay	Mouse
Lu , Xi, Kim-Han , Jeong So, Harmon , Steve, Sakiyama-Elbert , Shelly E, O'Malley , Karen L The Parkinsonian mimetic, 6-OHDA, impairs axonal transport in dopaminergic axons. Mol Neurodegener, 2014-05-03;9(0):17. 2014-05-03 [PMID: 24885281] (Bioassay, Mouse)	Bioassay	Mouse
Ramkhelawon B, Hennessy E, Menager M, Ray T, Sheedy F, Hutchison S, Wanschel A, Oldebeken S, Geoffrion M, Spiro W, Miller G, McPherson R, Rayner K, Moore K Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity. Nat Med, 2014-03-02;20(4):377-84. 2014-03-02 [PMID: 24584118] (Bioassay, Mouse)	Bioassay	Mouse
Chen J, Cai Q, Shen P, Yan R, Wang C, Yang D, Fu H, Chen X Netrin-1 protects against L-Arginine-induced acute pancreatitis in mice. PLoS ONE, 2012-09-27;7(9):e46201. 2012-09-27 [PMID: 23029434] (In Vivo, Mouse)	In Vivo	Mouse
Palmesino E, Haddick PC, Tessier-Lavigne M, Kania A Genetic analysis of DSCAM's role as a Netrin-1 receptor in vertebrates. J. Neurosci., 2012-01-11;32(2):411-6. 2012-01-11 [PMID: 22238077] (Bioassay, Mouse)	Bioassay	Mouse
Kim-Han JS, Antenor-Dorsey JA, O'Malley KL The Parkinsonian mimetic, MPP+, specifically impairs mitochondrial transport in dopamine axons. J. Neurosci., 2011-05-11;31(19):7212-21. 2011-05-11 [PMID: 21562285] (Bioassay, Mouse)	Bioassay	Mouse
Kuwako K, Kakumoto K, Imai T Neural RNA-binding protein Musashi1 controls midline crossing of precerebellar neurons through posttranscriptional regulation of Robo3/Rig-1 expression. Neuron, 2010-08-12;67(3):407-21. 2010-08-12 [PMID: 20696379] (Bioassay, Mouse)	Bioassay	Mouse
Tadagavadi RK, Wang W Netrin-1 Regulates Th1/Th2/Th17 Cytokine Production and Inflammation through UNC5B Receptor and Protects Kidney against Ischemia-Reperfusion Injury. J. Immunol., 2010-08-06;185(0):3750-8. 2010-08-06 [PMID: 20693423] (In Vivo, Mouse)	In Vivo	Mouse
Mancino M, Esposito C, Watanabe K, Nagaoka T, Gonzales M, Bianco C, Normanno N, Salomon DS, Strizzi L Neuronal guidance protein Netrin-1 induces differentiation in human embryonal carcinoma cells. Cancer Res., 2009-02-17;69(5):1717-21. 2009-02-17 [PMID: 19223540] (Bioassay, Human)	Bioassay	Human
Rosenberger P, Schwab JM, Mirakaj V, Masekowsky E, Mager A, Morote-Garcia JC, Unertl K, Eltzschig HK Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia. Nat. Immunol., 2009-01-04;10(2):195-202. 2009-01-04 [PMID: 19122655] (In Vivo, Mouse)	In Vivo	Mouse
Wu TW, Li WW, Li H Netrin-1 attenuates ischemic stroke-induced apoptosis. Neuroscience, 2008-08-22;156(3):475-82. 2008-08-22 [PMID: 18786616] (In Vivo, Mouse)	In Vivo	Mouse
Schaffar G, Taniguchi J, Brodbeck T, Meyer AH, Schmidt M, Yamashita T, Mueller BK LIM-only protein 4 interacts directly with the repulsive guidance molecule A receptor Neogenin. J. Neurochem., 2008-08-12;107(2):418-31. 2008-08-12 [PMID: 18702663] (Bioassay, Mouse)	Bioassay	Mouse
Strizzi L, Mancino M, Bianco C, Raafat A, Gonzales M, Booth BW, Watanabe K, Nagaoka T, Mack DL, Howard B, Callahan R, Smith GH, Salomon DS Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland. J. Cell. Physiol., 2008-09-01;216(3):824-34. 2008-09-01 [PMID: 18425773] (Bioassay, In Vivo, Mouse)	Bioassay, In Vivo	Mouse
Wang W, Reeves WB, Ramesh G Netrin-1 and kidney injury. I. Netrin-1 protects against ischemia-reperfusion injury of the kidney. Am. J. Physiol. Renal Physiol., 2008-01-23;294(4):F739-47. 2008-01-23 [PMID: 18216145] (In Vivo, Mouse)	In Vivo	Mouse
Isakova IA, Baker K, Dutreil M, Dufour J, Gaupp D, Phinney DG Age- and dose-related effects on MSC engraftment levels and anatomical distribution in the central nervous systems of nonhuman primates: identification of novel MSC subpopulations that respond to guidance cues in brain. Stem Cells, 2007-10-11;25(12):3261-70. 2007-10-11 [PMID: 17932418] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque))	Bioassay	Primate - Macaca mulatta (Rhesus Macaque)
Nguyen A, Cai H Netrin-1 induces angiogenesis via a DCC-dependent ERK1/2-eNOS feed-forward mechanism. Proc. Natl. Acad. Sci. U.S.A., 2006-04-12;103(17):6530-5. 2006-04-12 [PMID: 16611730] (Bioassay, Bovine)	Bioassay	Bovine
Show All 40 Publications. Collapse Publications.

Array 1109-N1

• Netrin-1 Antibodies
• Netrin-1 ELISA Kit
• Netrin-1 Protein
• Netrin-1 Proteins and Enzymes