PSENEN/PEN2 Antibody (JE41-28) Summary
Additional Information |
Recombinant Monoclonal Antibody. |
Immunogen |
Recombinant protein within Human PSENEN/PEN2 aa 1-101 / 101. (SwissProt: Q9NZ42 Human; SwissProt: Q9CQR7 Mouse; SwissProt: O88777 Rat) |
Localization |
Cell membrane. Endoplasmic reticulum. Golgi apparatus. |
Isotype |
IgG |
Clonality |
Monoclonal |
Host |
Rabbit |
Gene |
PSENEN |
Purity |
Protein A purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Flow Cytometry 1:50-1:100
- Immunocytochemistry/ Immunofluorescence 1:50-1:200
- Immunohistochemistry-Paraffin 1:50-1:200
- Western Blot 1:500-1:2000
|
Theoretical MW |
12 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Buffer |
TBS (pH7.4), 0.05% BSA, 40% Glycerol |
Preservative |
0.05% Sodium Azide |
Concentration |
1 mg/ml |
Purity |
Protein A purified |
Alternate Names for PSENEN/PEN2 Antibody (JE41-28)
Background
Presenilin (PS1/PS2) complexes are responsible for the intramembrane gamma-secretase cleavage of the beta-amyloid precursor protein. Presenilin enhancer 2 (PEN2) is an essential cofactor involved in physically interacting with PS1 and is necessary for gamma-secretase activity. Endogenous PEN2 preferentially interacts with PS1 holoprotein. Down-regulation of PEN2 expression abolishes the endoproteolysis of PS1 and overexpression promotes the production of PS1 fragments.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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