Universal Type I IFN Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: Bioassay, Cell Culture, In Vivo.

Showing Publications 1 - 10 of 30. Show All 30 Publications. Collapse Publications.

Publications using 11200-1	Applications	Species
J Song, RD Chow, M Pena-Herna, L Zhang, SA Loeb, EY So, OD Liang, P Ren, S Chen, CB Wilen, S Lee LRRC15 inhibits SARS-CoV-2 cellular entry in trans PloS Biology, 2022-10-13;20(10):e3001805. 2022-10-13 [PMID: 36228039] (Bioassay, Human)	Bioassay	Human
B Los, M Preu beta ner, K Eschke, RM Vidal, A Abdelgawad, D Olofsson, S Keiper, M Paulo-Pedr, A Grindel, S Meinke, J Trimpert, F Heyd Body temperature variation controls pre-mRNA processing and transcription of antiviral genes and SARS-CoV-2 replication Nucleic Acids Research, 2022-07-08;0(0):. 2022-07-08 [PMID: 35713540] (Bioassay, Human)	Bioassay	Human
X Yang, X Zhao, Y Zhu, Y Shen, Y Wang, P Lu, Z Jiang, H Pan, J Yang, J Xun, L Zhao, J Wang, Z Liang, X Shen, Y Liang, Q Lin, H Liang, L Jin, D Zhang, J Liu, B Wang, S Jiang, J Xu, H Wu, H Lu, H Zhu FKBP3 Induces Human Immunodeficiency Virus Type 1 Latency by Recruiting Histone Deacetylase 1/2 to the Viral Long Terminal Repeat MBio, 2021-07-20;0(0):e0079521. 2021-07-20 [PMID: 34281390] (Bioassay, Human)	Bioassay	Human
N Buang, L Tapeng, V Gray, A Sardini, C Whilding, L Lightstone, TD Cairns, MC Pickering, J Behmoaras, GS Ling, M Botto Type I interferons affect the metabolic fitness of CD8+ T cells from patients with systemic lupus erythematosus Nature Communications, 2021-03-31;12(1):1980. 2021-03-31 [PMID: 33790300] (Bioassay, Human)	Bioassay	Human
KP Singh, JM Zerbato, W Zhao, S Braat, C Deleage, GS Tennakoon, H Mason, A Dantanaray, A Rhodes, JW Rhodes, J Torresi, AN Harman, PA Revill, M Crane, JD Estes, A Avihingsan, SR Lewin, J Audsley Intrahepatic CXCL10 is strongly associated with liver fibrosis in HIV-Hepatitis B co-infection PLoS Pathog., 2020-09-08;16(9):e1008744. 2020-09-08 [PMID: 32898182] (Bioassay, Human)	Bioassay	Human
C Paulus, T Harwardt, B Walter, A Marxreiter, M Zenger, E Reuschel, MM Nevels Revisiting promyelocytic leukemia protein targeting by human cytomegalovirus immediate-early protein 1 PLoS Pathog., 2020-05-04;16(5):e1008537. 2020-05-04 [PMID: 32365141] (Cell Culture, Human)	Cell Culture	Human
RM Van der Sl, JM Zerbato, JW Rhodes, RD Pascoe, A Solomon, NA Kumar, AI Dantanaray, S Tennakoon, J Dufloo, J McMahon, JJ Chang, VA Evans, PJ Hertzog, MR Jakobsen, AN Harman, SR Lewin, PU Cameron Diverse effects of interferon alpha on the establishment and reversal of HIV latency PLoS Pathog., 2020-02-28;16(2):e1008151. 2020-02-28 [PMID: 32109259] (Cell Culture, Human)	Cell Culture	Human
E Kuca-Warna, U Skalska, I Janicka, U Musia?owic, K Bonek, P G?uszko, P Szcz?sny, M Olesi?ska, E Kontny The Phenotype and Secretory Activity of Adipose-Derived Mesenchymal Stem Cells (ASCs) of Patients with Rheumatic Diseases Cells, 2019-12-17;8(12):. 2019-12-17 [PMID: 31861245] (Cell Culture, Human)	Cell Culture	Human
F Vahedi, AJ Lee, SE Collins, MV Chew, E Lusty, B Chen, A Dubey, CD Richards, JJ Feld, RS Russell, KL Mossman, AA Ashkar IL-15 and IFN-? signal through the ERK pathway to inhibit HCV replication, independent of type I IFN signaling Cytokine, 2018-06-19;0(0):. 2018-06-19 [PMID: 29908921] (Bioassay, Human)	Bioassay	Human
K Matsuno, M Kajihara, R Nakao, N Nao, A Mori-Kajih, M Muramatsu, Y Qiu, S Torii, M Igarashi, N Kasajima, K Mizuma, K Yoshii, H Sawa, C Sugimoto, A Takada, H Ebihara The Unique Phylogenetic Position of a Novel Tick-Borne Phlebovirus Ensures an Ixodid Origin of the Genus Phlebovirus mSphere, 2018-06-13;3(3):. 2018-06-13 [PMID: 29898985] (Bioassay, Human)	Bioassay	Human
U Cytlak, A Resteu, D Bogaert, HS Kuehn, T Altmann, A Gennery, G Jackson, A Kumanovics, KV Voelkerdin, S Prader, M Dullaers, J Reichenbac, H Hill, F Haerynck, SD Rosenzweig, M Collin, V Bigley Ikaros family zinc finger 1 regulates dendritic cell development and function in humans Nat Commun, 2018-03-27;9(1):1239. 2018-03-27 [PMID: 29588478] (Bioassay, Human)	Bioassay	Human
X Dai, M Tohyama, M Murakami, K Sayama Epidermal keratinocytes sense dsRNA via the NLRP3 inflammasome, mediating interleukin (IL)-1? and IL-18 release Exp. Dermatol, 2017-05-12;0(0):. 2017-05-12 [PMID: 28266737] (Bioassay, Human)	Bioassay	Human
Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer Nature, 2016-05-18;533(7604):493-8. 2016-05-18 [PMID: 27225120] (Bioassay, Human)	Bioassay	Human
JF Hedges, A Robison, E Kimmel, K Christense, E Lucas, A Ramstead, MA Jutila Type I IFN counters or promotes Coxiella burnetii replication dependent on tissue Infect Immun, 2016-05-24;0(0):. 2016-05-24 [PMID: 27068091] (In Vivo, Mouse)	In Vivo	Mouse
Labzin L, Schmidt S, Masters S, Beyer M, Krebs W, Klee K, Stahl R, Lutjohann D, Schultze J, Latz E, De Nardo D ATF3 Is a Key Regulator of Macrophage IFN Responses. J Immunol, 2015-09-28;195(9):4446-55. 2015-09-28 [PMID: 26416280] (Bioassay, Human)	Bioassay	Human
Berri F, Haffar G, Le V, Sadewasser A, Paki K, Lina B, Wolff T, Riteau B Annexin V incorporated into influenza virus particles inhibits gamma interferon signaling and promotes viral replication. J Virol, 2014-07-16;88(19):11215-28. 2014-07-16 [PMID: 25031344] (Bioassay, Human)	Bioassay	Human
Cimica V, Dalrymple N, Roth E, Nasonov A, Mackow E An innate immunity-regulating virulence determinant is uniquely encoded by the Andes virus nucleocapsid protein. MBio, 2014-02-18;5(1):. 2014-02-18 [PMID: 24549848] (Bioassay, Human)	Bioassay	Human
Ray A, Tian Z, Das D, Coffman R, Richardson P, Chauhan D, Anderson K A novel TLR-9 agonist C792 inhibits plasmacytoid dendritic cell-induced myeloma cell growth and enhance cytotoxicity of bortezomib. Leukemia, 2014-01-30;28(8):1716-24. 2014-01-30 [PMID: 24476765] (Bioassay, Human)	Bioassay	Human
Li X, Jiang L, Chen L, Ding M, Guo H, Zhang W, Zhang H, Ma X, Liu X, Xi X, Chen S, Chen Z, Zhu J RIG-I modulates Src-mediated AKT activation to restrain leukemic stemness. Mol Cell, 2014-01-09;53(3):407-19. 2014-01-09 [PMID: 24412064] (Bioassay, Human)	Bioassay	Human
Li W, Okuda A, Yamamoto H, Yamanishi K, Terada N, Yamanishi H, Tanaka Y, Okamura H Regulation of development of CD56 bright CD11c + NK-like cells with helper function by IL-18. PLoS ONE, 2013-12-20;8(12):e82586. 2013-12-20 [PMID: 24376549] (Bioassay, Human)	Bioassay	Human
Wang T, Ge Y, Xiao M, Lopez-Coral A, Li L, Roesch A, Huang C, Alexander P, Vogt T, Xu X, Hwang W, Lieu M, Belser E, Liu R, Somasundaram R, Herlyn M, Kaufman R SECTM1 produced by tumor cells attracts human monocytes via CD7-mediated activation of the PI3K pathway. J Invest Dermatol, 2013-10-24;134(4):1108-18. 2013-10-24 [PMID: 24157461] (Bioassay, Human)	Bioassay	Human
Webster , Brian, Ott , Melanie, Greene , Warner C Evasion of superinfection exclusion and elimination of primary viral RNA by an adapted strain of hepatitis C virus. J Virol, 2013-10-02;87(24):13354-69. 2013-10-02 [PMID: 24089557] (Bioassay, Human)	Bioassay	Human
Chen , Qian, Swaminathan , Sanjay, Yang , De, Dai , Lue, Sui , Hongyan, Yang , Jun, Hornung , Ronald L, Wang , Yanmei, Huang , Da Wei, Hu , Xiaojun, Lempicki , Richard, Imamichi , Tomozumi Interleukin-27 is a potent inhibitor of cis HIV-1 replication in monocyte-derived dendritic cells via a type I interferon-independent pathway. PLoS ONE, 2013-03-20;8(3):e59194. 2013-03-20 [PMID: 23527130] (Bioassay, Human)	Bioassay	Human
Rosen L, Freeman A, Yang L, Jutivorakool K, Olivier K, Angkasekwinai N, Suputtamongkol Y, Bennett J, Pyrgos V, Williamson P, Ding L, Holland S, Browne S Anti-GM-CSF autoantibodies in patients with cryptococcal meningitis. J Immunol, 2013-03-18;190(8):3959-66. 2013-03-18 [PMID: 23509356] (Bioassay, Human)	Bioassay	Human
Srivastava R, Lee S, Andrade Filho P, Lord C, Jie H, Davidson H, Lopez-Albaitero A, Gibson S, Gooding W, Ferrone S, Ferris R Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patients. Clin Cancer Res, 2013-02-26;19(7):1858-72. 2013-02-26 [PMID: 23444227] (Bioassay, Human)	Bioassay	Human
Jones P, Maric M, Madison M, Maury W, Roller R, Okeoma C BST-2/tetherin-mediated restriction of chikungunya (CHIKV) VLP budding is counteracted by CHIKV non-structural protein 1 (nsP1). Virology, 2013-02-12;438(1):37-49. 2013-02-12 [PMID: 23411007] (Bioassay, Human)	Bioassay	Human
Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 2012-07-26;487(7408):505-9. 2012-07-26 [PMID: 22763448] (Bioassay, Human)	Bioassay	Human
Cilloniz C, Pantin-Jackwood MJ, Ni C, Carter VS, Korth MJ, Swayne DE, Tumpey TM, Katze MG Molecular signatures associated with Mx1-mediated resistance to highly pathogenic influenza virus infection: mechanisms of survival. J. Virol., 2011-12-21;86(5):2437-46. 2011-12-21 [PMID: 22190720] (In Vivo, Mouse)	In Vivo	Mouse
Knoblach T, Grandel B, Seiler J, Nevels M, Paulus C Human cytomegalovirus IE1 protein elicits a type II interferon-like host cell response that depends on activated STAT1 but not interferon-gamma. PLoS Pathog., 2011-04-14;7(4):e1002016. 2011-04-14 [PMID: 21533215] (Bioassay, Human)	Bioassay	Human
Albanesi C, Scarponi C, Pallotta S, Daniele R, Bosisio D, Madonna S, Fortugno P, Gonzalvo-Feo S, Franssen JD, Parmentier M, De Pita O, Girolomoni G, Sozzani S Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment. J. Exp. Med., 2008-12-29;206(1):249-58. 2008-12-29 [PMID: 19114666] (Bioassay, Human)	Bioassay	Human
Show All 30 Publications. Collapse Publications.

Array 11200-1

• IFN-alpha Antibodies
• IFN-alpha ELISA Kits
• IFN-alpha ELISAs
• IFN-alpha Proteins and Enzymes