Choline Acetyltransferase/ChAT Antibody

Cholinergic systems are implicated in numerous neurologic functions. Alteration in some cholinergic neurons may account for the disturbances of Alzheimer disease. The protein encoded by this gene synthesizes the neurotransmitter acetylcholine. Alternative splice variants have been found that contain alternative 5' untranslated exons. Three of the four described splice variants encode identical 69 kDa proteins while one variant encodes both the 69 kDa and a larger 82 kDa protein.; Choline acetylase catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.; CATALYTIC ACTIVITY: Acetyl-CoA + choline = CoA + O-acetylcholine.; Defects in CHAT are the cause of familial infantile myasthenia gravis 2 (FIMG2); also known as CMS-EA. FIMG2 patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement. Inheritance is autosomal recessive.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 8 applications: EM, ICC/IF, IF/IHC, IHC, IHC-Fr, IHC-FrFl, IHC-WhMt, WB.

Showing Publications 1 - 10 of 22. Show All 22 Publications. Collapse Publications.

Publications using NBP1-30052	Applications	Species
Liu S, Xiang K, Yuan F, Xiang M Generation of self-organized autonomic ganglion organoids from fibroblasts iScience 2023-03-01 [PMID: 36922996]
Wang J, Xu L, Peng D et al. IFN-?-STAT1-mediated CD8+ T-cell-neural stem cell cross talk controls astrogliogenesis after spinal cord injury Inflammation and regeneration 2023-02-13 [PMID: 36782279] (IHC, ICC/IF, Mouse)	IHC, ICC/IF	Mouse
You J, Maksimovic K, Lee J et al. Selective Loss of MATR3 in Spinal Interneurons, Upper Motor Neurons and Hippocampal CA1 Neurons in a MATR3 S85C Knock-In Mouse Model of Amyotrophic Lateral Sclerosis Biology 2022-02-12 [PMID: 35205163] (IF/IHC, Mouse)	IF/IHC	Mouse
Radzimirska M, Kuchinka J, Kuder T Et al. Distribution and neurochemical characteristic of the cardiac nerve structures in the heart of chinchilla (Chinchilla laniger Molina) Folia histochemica et cytobiologica 2021-09-28 [PMID: 34581422]
Tassone A, Martella G, Meringolo M et al. Vesicular Acetylcholine Transporter Alters Cholinergic Tone and Synaptic Plasticity in DYT1 Dystonia Movement disorders : official journal of the Movement Disorder Society 2021-06-26 [PMID: 34173686]
Li Z, Wang Y, Jiang Y et al. Xiao-Qing-Long-Tang Maintains Cardiac Function during Heart Failure with Reduced Ejection Fraction in Salt-Sensitive Rats by Regulating the Imbalance of Cardiac Sympathetic Innervation Evidence-Based Complementary and Alternative Medicine 2020-11-24 [PMID: 33628295] (EM)	EM
Yao Y, Wang J, He T et al. Microarray assay of circular RNAs reveals cicRNA.7079 as a new anti-apoptotic molecule in spinal cord injury in mice Brain Res Bull 2020-09-04 [PMID: 32882320]
Radzimirska M, Kuchinka J, Nowak E et al. Cholinergic and adrenergic innervation of the pancreas in chinchilla (Chinchilla Laniger Molina) Folia Histochemica et Cytobiologica 2020-04-09 [PMID: 32202307] (IHC)	IHC
Bonsi P, Ponterio G, Vanni V et al. RGS9-2 rescues dopamine D2 receptor levels and signaling in DYT1 dystonia mouse models EMBO Mol Med 2018-12-14 [PMID: 30552094] (ICC/IF, Mouse)	ICC/IF	Mouse
Sun T, Li D, Hu S et al. Aging-dependent decrease in the numbers of enteric neurons, interstitial cells of Cajal and expression of connexin43 in various regions of gastrointestinal tract. Aging (Albany NY) 2018-12-11 [PMID: 30530917] (ICC/IF, WB, Mouse)	ICC/IF, WB	Mouse
Mellone M, Zianni E, Stanic J et al. NMDA receptor GluN2D subunit participates to levodopa-induced dyskinesia pathophysiology. Neurobiol. Dis. 2018-09-24 [PMID: 30261285] (IHC-FrFl, Rat)	IHC-FrFl	Rat
Palomo GM, Granatiero V, Kawamata H et al. Parkin is a disease modifier in the mutant SOD1 mouse model of ALS EMBO Mol Med 2018-08-20 [PMID: 30126943] (IF/IHC, Mouse)	IF/IHC	Mouse
Simandi Z, Pajer K, Karolyi K et al. Arginine Methyltransferase PRMT8 Provides Cellular Stress Tolerance in Aging Motoneurons J. Neurosci. 2018-08-29 [PMID: 30054395] (WB, Mouse)	WB	Mouse
Rotheneichner P, Belles M, Benedetti B et al. Cellular Plasticity in the Adult Murine Piriform Cortex: Continuous Maturation of Dormant Precursors Into Excitatory Neurons Cereb. Cortex 2018-04-21 [PMID: 29688272] (IF/IHC, Mouse)	IF/IHC	Mouse
Burstein SR, Valsecchi F, Kawamata H et al. In vitro and in vivo studies of the ALS-FTLD protein CHCHD10 reveal novel mitochondrial topology and protein interactions Hum. Mol. Genet. 2017-11-03 [PMID: 29112723] (Mouse)		Mouse
Stanic J, Mellone M, Napolitano F et al. Rabphilin 3A: A novel target for the treatment of levodopa-induced dyskinesias Neurobiol. Dis. 2017-08-18 [PMID: 28823933] (IF/IHC, Rat)	IF/IHC	Rat
Gelfo F, Cutuli D, Nobili A et al. Chronic Lithium Treatment in a Rat Model of Basal Forebrain Cholinergic Depletion: Effects on Memory Impairment and Neurodegeneration. J. Alzheimers Dis. 2017-02-22 [PMID: 28222508]
Zhang GQ, Yang S, Li XS, Zhou DS. Expression and possible role of IGF-IR in the mouse gastric myenteric plexus and smooth muscles. Acta Histochem. 2014-03-12 [PMID: 24630395] (IHC-Fr, IHC-WhMt, Mouse)	IHC-Fr, IHC-WhMt	Mouse
Martella G, Maltese M, Nistico R et al. Regional specificity of synaptic plasticity deficits in a knock-in mouse model of DYT1 dystonia. Neurobiol. Dis. 2014-03-03 [PMID: 24503369] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Ponterio G, Tassone A, Sciamanna G et al. Powerful inhibitory action of mu opioid receptors (MOR) on cholinergic interneuron excitability in the dorsal striatum. Neuropharmacology 2013-07-25 [PMID: 23891638] (ICC/IF, IF/IHC, Mouse)	ICC/IF, IF/IHC	Mouse
Liu J, Tu H, Zhang D et al. Voltage-gated sodium channel expression and action potential generation in differentiated NG108-15 cells BMC Neurosci 2012-10-25 [PMID: 23095258] (ICC/IF, Rat, Mouse)	ICC/IF	Rat, Mouse
Sciamanna G, Tassone A, Martella G et al. Developmental Profile of the Aberrant Dopamine D2 Receptor Response in Striatal Cholinergic Interneurons in DYT1 Dystonia. PLoS ONE;6(9). 2011-01-01 [PMID: 21912682] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Show All 22 Publications. Collapse Publications.

Array NBP1-30052

• Choline Acetyltransferase/ChAT Antibodies
• Choline Acetyltransferase/ChAT ELISA Kits
• Choline Acetyltransferase/ChAT Kits
• Choline Acetyltransferase/ChAT Lysate
• Choline Acetyltransferase/ChAT Proteins