SOD2/Mn-SOD Antibody (349810) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Superoxide Dismutases (SODs), originally identified as Indophenoloxidases (IPOs), are enzymes that catalyze the conversion of naturally-occuring but harmful superoxide radicals into molecular oxygen and hydrogen peroxide. Superoxide Dismutases 2 (SOD2), also known as Manganese (Mn) SOD, mitochondrial SOD, and IPO-B, is an intramitochondrial 22 kDa homotetramer. Each SOD2 monomer binds one Mn²⁺ ion. Three isozymes of SOD have been identified and are functionally related but have very modest sequence homology. SOD2 shares only 23% and 17% sequence identity with SOD1 and SOD3, respectively. SOD2 is, however, well conserved from species to species and shares 90% and 87% homology with mouse and rat SOD2, respectively. Oxidative stress has been implicated in many diseases and the chief source of reactive oxygen species within the cell is the mitochondrion. SOD2 is a free radical scavenging enzyme that protects against damage from superoxide produced as a byproduct of oxidative phosphorylation. SOD2 is required for normal biologic function of tissues by maintaining the integrity of mitochondrial enzymes susceptible to inactivation by superoxide. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Porcine.

We have publications tested in 2 applications: ICC, Western Blot.

Showing Publications 1 - 7 of 7.

Publications using MAB3419	Applications	Species
Woo J, Seo H, Lee J et al. Polypropylene microplastic exposure leads to lung inflammation through p38-mediated NF- kappa B pathway due to mitochondrial damage Research Square 7/8/2022 [PMID: 36624477]
P Wohlrab, L Soto-Gonza, T Benesch, MP Winter, IM Lang, K Markstalle, V Tretter, KU Klein Intermittent Hypoxia Activates Duration-Dependent Protective and Injurious Mechanisms in Mouse Lung Endothelial Cells Front Physiol, 2018-12-06;9(0):1754. 2018-12-06 [PMID: 30574096] (Western Blot, Mouse)	Western Blot	Mouse
JM Adrian-Seg, K Sreenivasa, P Gajawada, H Lörchner, T Braun, J Pöling The AB loop of oncostatin M (OSM) determines species-specific signaling in humans and mice J. Biol. Chem., 2018-10-29;0(0):. 2018-10-29 [PMID: 30373773] (Western Blot, Human)	Western Blot	Human
S Sun, J Liu, M Zhao, Y Han, P Chen, Q Mo, B Wang, G Chen, Y Fang, Y Tian, J Zhou, D Ma, Q Gao, P Wu Loss of the novel mitochondrial protein FAM210B promotes metastasis via PDK4-dependent metabolic reprogramming Cell Death Dis, 2017-06-08;8(6):e2870. 2017-06-08 [PMID: 28594398] (Western Blot, Human)	Western Blot	Human
Saraf R, Huang T, Mahmood F, Owais K, Bardia A, Khabbaz K, Liu D, Senthilnathan V, Lassaletta A, Sellke F, Matyal R Early Cellular Changes in the Ascending Aorta and Myocardium in a Swine Model of Metabolic Syndrome. PLoS ONE, 2016-01-14;11(1):e0146481. 2016-01-14 [PMID: 26766185] (Western Blot, Porcine)	Western Blot	Porcine
Van Brussel , Ilse, Schrijvers , Dorien M, Martinet , Wim, Pintelon , Isabel, Deschacht , Maartje, Schnorbusch , Kathy, Maes , Louis, Bosmans , Johan M, Vrints , Christia, Adriaensen , Dirk, Cos , Paul, Bult , Hidde Transcript and protein analysis reveals better survival skills of monocyte-derived dendritic cells compared to monocytes during oxidative stress. PLoS ONE, 2012-08-15;7(8):e43357. 2012-08-15 [PMID: 22916248] (ICC, Western Blot, Human)	ICC, Western Blot	Human
Duan W, Peng Q, Masuda N, Ford E, Tryggestad E, Ladenheim B, Zhao M, Cadet JL, Wong J, Ross CA Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease. Neurobiol. Dis., 2008-03-10;30(3):312-22. 2008-03-10 [PMID: 18403212] (Western Blot, Mouse)	Western Blot	Mouse

Array MAB3419

• SOD2/Mn-SOD Antibodies
• SOD2/Mn-SOD Lysates
• SOD2/Mn-SOD Proteins
• SOD2/Mn-SOD ELISA