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SOD2/Mn-SOD Antibody (012) [Biotin]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clone
012
Clonality
Monoclonal
Host
Rabbit
Conjugate
Biotin

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-90139AF350
Alexa Fluor 405
NBP2-90139AF405
Alexa Fluor 488
NBP2-90139AF488
Alexa Fluor 532
NBP2-90139AF532
Alexa Fluor 594
NBP2-90139AF594
Alexa Fluor 647
NBP2-90139AF647
Alexa Fluor 700
NBP2-90139AF700
Alexa Fluor 750
NBP2-90139AF750
Allophycocyanin
NBP2-90139APC
DyLight 350
NBP2-90139UV
DyLight 405
NBP2-90139V
DyLight 488
NBP2-90139G
DyLight 550
NBP2-90139R
DyLight 594
NBP2-90139DL594
DyLight 650
NBP2-90139C
DyLight 680
NBP2-90139FR
DyLight 755
NBP2-90139IR
FITC
NBP2-90139F
HRP
NBP2-90139H
Janelia Fluor 549
NBP2-90139JF549
Janelia Fluor 646
NBP2-90139JF646
PE
NBP2-90139PE
PerCP
NBP2-90139PCP
Unconjugated
NBP2-90139-100ul
mFluor Violet 450 SE
NBP2-90139MFV450
mFluor Violet 500 SE
NBP2-90139MFV500
mFluor Violet 610 SE
NBP2-90139MFV610
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SOD2/Mn-SOD Antibody (012) [Biotin] Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
This antibody was obtained from a rabbit immunized with purified, recombinant Human SOD2/Mn-SOD (Uniprot#: P04179-1; Lys25-Lys222).
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
SOD2
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Alternate Names for SOD2/Mn-SOD Antibody (012) [Biotin]

  • EC 1.15.1.1
  • indophenoloxidase B
  • IPOB
  • IPO-B
  • manganese-containing superoxide dismutase
  • mangano-superoxide dismutase
  • Mn SOD
  • Mn superoxide dismutase
  • MnSOD
  • MVCD6
  • SOD, Mitochodrial
  • SOD2
  • superoxide dismutase [Mn], mitochondrial
  • superoxide dismutase 2, mitochondrial

Background

Superoxide dismutase (SOD) is responsible for the elimination of cytotoxic active oxygen by catalyzing the dismutation of the superoxide radical to oxygen and hydrogen peroxide (1, 2, 3). There are three SOD isoenzymes in mammalian cells. They are: extracellular SOD (EC SOD), copper and zinc-containing SOD (CuZn SOD) and manganese-containing SOD (Mn SOD, SOD-2). The CuZn form contains Cu and Zn ions and exists as a 32 kDa dimer in the cytosol. Mn SOD is an 80 kDa tetramer that contains Mn ion and resides in the mitochondrial matrix. Mn SOD is a tumor necrosis factor (TNF)-inducible enzyme that protects cells from NFmediated apoptosis (4) via superoxide anion detoxification and the subsequent regulation of apoptosis through cytochrome c release and the modulation of the redox state of the mitochondria (6). Mn SOD has also been shown to be a tumor suppressor in human breast cancer (7). Overexpression of this enzyme protects neurons from NMDAand nitric oxide-induced neurotoxicity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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SOD2/Mn-SOD
Antibody (012) [Bioti
NBP2-90139B
SOD2/Mn-SOD Antibody (012) [Biotin]
Species: Hu
Applications: IHC

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Bioinformatics

Gene Symbol SOD2