Recombinant Mouse FAM3C Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Family with sequence similarity 3, member C (FAM3C), also known as Interleukin-Like EMT Inducer (ILEI), is an approximately 25 kDa secreted protein in the FAM group of molecules (1, 2). Members of this family share a four helix bundle secondary structure similar to that found in many cytokines. Mature mouse FAM3C shares 94% and 97% amino acid sequence identity with human and rat FAM3C, respectively. It is widely expressed, notably in the nonsensory epithelium of auditory semicircular canals (1) and in the photoreceptor layer of the retina (3). FAM3C is up‑regulated and shows altered intracellular localization in various tumors (4, 5). Its translation is normally silenced by the binding of hnRNP E1 to the FAM3C mRNA, but this inhibition is removed following cellular exposure to TGF-beta (6, 7). FAM3C, like TGF-beta , promotes epithelial-mesenchymal transition (EMT), tumor growth, and metastasis (4-6). FAM3C cooperates with oncogenic Ras to promote the up‑regulation of PDGF-C and PDGF R beta , leading to increased PDGF receptor signaling (5). R&D Systems in-house testing indicates that FAM3C supports the adhesion of Caki cells.

Array 2868-FM

• FAM3C Antibodies
• FAM3C Lysates
• FAM3C Proteins
• FAM3C Proteins and Enzyme