Recombinant Mouse Ephrin-A1 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Ephrin-A1, also known as B61 and LERK-1, is a member of the Ephrin-A family of GPI-anchored ligands that bind and induce the tyrosine autophosphorylation of Eph receptors. Ephrin-A ligands are structurally related to the extracellular domains of the transmembrane Ephrin-B ligands. Eph-Ephrin interactions are widely involved in the regulation of cell migration, tissue morphogenesis, and cancer progression (1, 2). Mouse Ephrin-A1 is synthesized with an 17 amino acid (aa) signal peptide, a 165 aa mature chain, and a 23 aa C‑terminal propeptide which is removed prior to GPI linkage of Ephrin-A1 to the membrane (3, 4). It can also be released as a soluble molecule (3, 5, 6). The mature 21 ‑ 25 kDa mouse Ephrin-A1 shares 85% and 94% aa sequence identity with human and rat Ephrin-A1, respectively. Ephrin-A1 is widely expressed on endothelial and epithelial cells, particularly in the lung, intestine, liver, and skin (4, 8). It is expressed on resting CD4+ T cells but is down‑regulated following activation (7, 8). Ligation of Ephrin-A1 on CD4+ T cells inhibits cell proliferation and activation, although soluble Ephrin-A1 can promote T cell chemotaxis (7, 8). In cancer, Ephrin‑A1 is expressed by tumor cells as well as on the tumor-associated vasculature (5, 6, 9). It inhibits tumor cell proliferation and migration but also supports tumor growth by promoting angiogenesis (10 - 12). Soluble Ephrin-A1 additionally promotes neuronal survival and neurite extension (13).

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Canine, Virus - Henipavirus.

We have publications tested in 4 applications: Binding Assay, Bioassay, Coprecipitation Assay, In Vivo.

Showing Publications 1 - 10 of 20. Show All 20 Publications. Collapse Publications.

Publications using 602-A1	Applications	Species
L Zhang, C Zhou, Y Zhou, W Zhang, X Hu, M Chen, H Hui, L Guo, C Wu, J Zhou, H Yin P-Y/G@NHs sensitizes non-small cell lung cancer cells to radiotherapy via blockage of the PI3K/AKT signaling pathway Bioorganic chemistry, 2022-12-06;131(0):106317. 2022-12-06 [PMID: 36525920] (Bioassay, Mouse)	Bioassay	Mouse
MP Gehring, EB Pasquale Protein kinase C phosphorylates the EphA2 receptor on serine 892 in the regulatory linker connecting the kinase and SAM domains Cell. Signal., 2020-05-13;73(0):109668. 2020-05-13 [PMID: 32413552] (Bioassay, Human)	Bioassay	Human
TK Darling, PN Mimche, C Bray, B Umaru, LM Brady, C Stone, CE Eboumbou M, TE Lane, LS Ayong, TJ Lamb EphA2 contributes to disruption of the blood-brain barrier in cerebral malaria PLoS Pathog., 2020-01-30;16(1):e1008261. 2020-01-30 [PMID: 31999807] (Bioassay, Mouse)	Bioassay	Mouse
ED Laing, CK Navaratnar, S Cheliout D, SR Petzing, Y Xu, SL Sterling, GA Marsh, LF Wang, M Amaya, DB Nikolov, R Cattaneo, CC Broder, K Xu Structural and functional analyses reveal promiscuous and species specific use of ephrin receptors by Cedar virus Proc. Natl. Acad. Sci. U.S.A., 2019-09-23;0(0):. 2019-09-23 [PMID: 31548390] (Coprecipitation Assay, Virus - Henipavirus)	Coprecipitation Assay	Virus - Henipavirus
Barquilla A, Lamberto I, Heynen-Genel S, Brill L, Pasquale E Protein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylation. Mol Biol Cell, 2016-07-06;27(17):2757-70. 2016-07-06 [PMID: 27385333] (Bioassay, Human)	Bioassay	Human
Kobayashi H, Saito T, Sato K, Furusawa K, Hosokawa T, Tsutsumi K, Asada A, Kamada S, Ohshima T, Hisanaga S Phosphorylation of cyclin-dependent kinase 5 (Cdk5) at Tyr-15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk5. J Biol Chem, 2014-05-28;289(28):19627-36. 2014-05-28 [PMID: 24872417] (Bioassay, Mouse)	Bioassay	Mouse
Naudin C, Sirvent A, Leroy C, Larive R, Simon V, Pannequin J, Bourgaux J, Pierre J, Robert B, Hollande F, Roche S SLAP displays tumour suppressor functions in colorectal cancer via destabilization of the SRC substrate EPHA2. Nat Commun, 2014-01-01;5(0):3159. 2014-01-01 [PMID: 24457997] (Bioassay, Human)	Bioassay	Human
Ieguchi K, Tomita T, Omori T, Komatsu A, Deguchi A, Masuda J, Duffy S, Coulthard M, Boyd A, Maru Y ADAM12-cleaved ephrin-A1 contributes to lung metastasis. Oncogene, 2013-05-20;33(17):2179-90. 2013-05-20 [PMID: 23686306] (Bioassay, In Vivo, Human, Mouse)	Bioassay, In Vivo	Human, Mouse
Giorgio C, Hassan Mohamed I, Flammini L, Barocelli E, Incerti M, Lodola A, Tognolini M Lithocholic acid is an Eph-ephrin ligand interfering with Eph-kinase activation. PLoS ONE, 2011-03-30;6(3):e18128. 2011-03-30 [PMID: 21479221] (Binding Assay, Human)	Binding Assay	Human
Dunaway CM, Hwang Y, Lindsley CW Cooperative signaling between Slit2 and Ephrin-A1 regulates a balance between angiogenesis and angiostasis. Mol. Cell. Biol., 2010-12-06;31(3):404-16. 2010-12-06 [PMID: 21135133] (In Vivo, Mouse)	In Vivo	Mouse
Afshari FT, Kwok JC, Fawcett JW Astrocyte-produced ephrins inhibit schwann cell migration via VAV2 signaling. J. Neurosci., 2010-03-24;30(12):4246-55. 2010-03-24 [PMID: 20335460] (Bioassay, Rat)	Bioassay	Rat
Miura K, Nam JM, Kojima C, Mochizuki N, Sabe H EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts. Mol. Biol. Cell, 2009-02-04;20(7):1949-59. 2009-02-04 [PMID: 19193766] (Bioassay, Canine)	Bioassay	Canine
Wykosky J, Palma E, Gibo DM Soluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptor. Oncogene, 2008-09-15;27(58):7260-73. 2008-09-15 [PMID: 18794797] (Bioassay, Human)	Bioassay	Human
Yamashita T, Ohneda K, Nagano M, Miyoshi C, Kaneko N, Miwa Y, Yamamoto M, Ohneda O, Fujii-Kuriyama Y Hypoxia-inducible transcription factor-2alpha in endothelial cells regulates tumor neovascularization through activation of ephrin A1. J. Biol. Chem., 2008-04-23;283(27):18926-36. 2008-04-23 [PMID: 18434321] (Bioassay, Mouse)	Bioassay	Mouse
Masuda J, Usui R, Maru Y Fibronectin type I repeat is a nonactivating ligand for EphA1 and inhibits ATF3-dependent angiogenesis. J. Biol. Chem., 2008-02-28;283(19):13148-55. 2008-02-28 [PMID: 18308734] (Bioassay, Human)	Bioassay	Human
Hong S, Kang UJ, Isacson O, Kim KS Neural precursors derived from human embryonic stem cells maintain long-term proliferation without losing the potential to differentiate into all three neural lineages, including dopaminergic neurons. J. Neurochem., 2007-10-18;104(2):316-24. 2007-10-18 [PMID: 17944878] (Bioassay, Mouse)	Bioassay	Mouse
Konstantinova I, Nikolova G, Ohara-Imaizumi M, Meda P, Kucera T, Zarbalis K, Wurst W, Nagamatsu S, Lammert E EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets. Cell, 2007-04-20;129(2):359-70. 2007-04-20 [PMID: 17448994] (Bioassay, Mouse)	Bioassay	Mouse
Chaudhari A, Mahfouz M, Fialho AM, Yamada T, Granja AT, Zhu Y, Hashimoto W, Schlarb-Ridley B, Cho W, Das Gupta TK, Chakrabarty AM Cupredoxin-cancer interrelationship: azurin binding with EphB2, interference in EphB2 tyrosine phosphorylation, and inhibition of cancer growth. Biochemistry, 2007-01-24;46(7):1799-810. 2007-01-24 [PMID: 17249693] (Binding Assay, Human)	Binding Assay	Human
Macrae M, Neve RM, Rodriguez-Viciana P, Haqq C, Yeh J, Chen C, Gray JW, McCormick F A conditional feedback loop regulates Ras activity through EphA2. Cancer Cell, 2005-08-01;8(2):111-8. 2005-08-01 [PMID: 16098464] (Bioassay, Human)	Bioassay	Human
Sharfe N, Freywald A, Toro A, Dadi H, Roifman C Ephrin stimulation modulates T cell chemotaxis. Eur. J. Immunol., 2002-12-01;32(12):3745-55. 2002-12-01 [PMID: 12516569] (Bioassay, Human)	Bioassay	Human
Show All 20 Publications. Collapse Publications.

Array 602-A1

• Ephrin-A1 Antibodies
• Ephrin-A1 Antibody Pair
• Ephrin-A1 ELISA Kits
• Ephrin-A1 Lysates
• Ephrin-A1 Proteins
• Ephrin-A1 Proteins and Enzymes