Recombinant Mouse Ephrin-A1 Fc Chimera Biotinylated Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Ephrin-A1, also known as B61 and LERK-1, is a member of the Ephrin-A family of GPI-anchored ligands that bind and induce the tyrosine autophosphorylation of Eph receptors. Ephrin-A ligands are structurally related to the extracellular domains of the transmembrane Ephrin-B ligands. Eph-Ephrin interactions are widely involved in the regulation of cell migration, tissue morphogenesis, and cancer progression (1, 2). Mouse Ephrin-A1 is synthesized with an 17 amino acid (aa) signal peptide, a 165 aa mature chain, and a 23 aa C‑terminal propeptide which is removed prior to GPI linkage of Ephrin-A1 to the membrane (3, 4). It can also be released as a soluble molecule (3, 5, 6). The mature 21‑25 kDa mouse Ephrin-A1 shares 85% and 94% aa sequence identity with human and rat Ephrin-A1, respectively. Ephrin-A1 is widely expressed on endothelial and epithelial cells, particularly in the lung, intestine, liver, and skin (4, 8). It is expressed on resting CD4+ T cells but is down‑regulated following activation (7, 8). Ligation of Ephrin-A1 on CD4+ T cells inhibits cell proliferation and activation, although soluble Ephrin-A1 can promote T cell chemotaxis (7, 8). In cancer, Ephrin‑A1 is expressed by tumor cells as well as on the tumor-associated vasculature (5, 6, 9). It inhibits tumor cell proliferation and migration but also supports tumor growth by promoting angiogenesis (10‑12). Soluble Ephrin-A1 additionally promotes neuronal survival and neurite extension (13).

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: Binding Assay, Bioassay, Immunoprecipitation.

Showing Publications 1 - 3 of 3.

Publications using BT602	Applications	Species
M Takasugi, R Okada, A Takahashi, D Virya Chen, S Watanabe, E Hara Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2 Nat Commun, 2017-06-06;8(0):15729. 2017-06-06 [PMID: 28585531] (Bioassay, Mouse)	Bioassay	Mouse
Barquilla A, Lamberto I, Heynen-Genel S, Brill L, Pasquale E Protein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylation. Mol Biol Cell, 2016-07-06;27(17):2757-70. 2016-07-06 [PMID: 27385333] (Immunoprecipitation, Human)	Immunoprecipitation	Human
Giorgio C, Hassan Mohamed I, Flammini L, Barocelli E, Incerti M, Lodola A, Tognolini M Lithocholic acid is an Eph-ephrin ligand interfering with Eph-kinase activation. PLoS ONE, 2011-03-30;6(3):e18128. 2011-03-30 [PMID: 21479221] (Binding Assay, Human)	Binding Assay	Human

Array BT602

• Ephrin-A1 Antibodies
• Ephrin-A1 Antibody Pair
• Ephrin-A1 ELISA Kits
• Ephrin-A1 Lysates
• Ephrin-A1 Proteins
• Ephrin-A1 Proteins and Enzymes