Recombinant Mouse CD90/Thy1 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CD90, also known as Thy1, is an approximately 25-35 kDa glycoprotein that mediates cellular adhesion and exerts wide ranging effects in different tissues (1, 2). Mature mouse CD90 contains one immunoglobulin-like domain followed by a GPI anchor (3-5). CD90 is expressed on hematopoietic progenitor cells, neurons, and activated vascular endothelial cells (6-8). Its species-specific expression in lymphoid cells allows its use as a thymocyte and pan T cell marker in mouse but not in human (1). CD90 can form dimers and higher order multimers (9). It binds to heparin, the proteoglycan Syndecan-4, and Integrins alpha M beta 2, alpha V beta 3, and  alpha V beta 5 (8, 10-13). Through these interactions, CD90 inhibits neurite outgrowth (7), promotes astrocyte adhesion (10), mediates the adhesion and extravasation of leukocytes and melanoma cells (8, 12), supports the Thrombospondin-1 induced disassembly of fibroblast focal adhesions (14), and inhibits the activation of latent TGF-beta 1, myofibroblast differentiation, and lung fibrosis (13)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: Bioassay, Flow Cytometry.

Showing Publications 1 - 2 of 2.

Publications using 7335-CD	Applications	Species
ACH Szeto, ACF Ferreira, J Mannion, PA Clark, M Sivasubram, MWD Heycock, A Crisp, HE Jolin, P Kozik, MD Knolle, ANJ McKenzie An alphavbeta3 integrin checkpoint is critical for efficient TH2 cell cytokine polarization and potentiation of antigen-specific immunity Nature Immunology, 2022-12-22;24(1):123-135. 2022-12-22 [PMID: 36550322] (Bioassay, Mouse)	Bioassay	Mouse
L Abou-Elkac, H Wang, SM Chowdhury, RH Kimura, SV Bachawal, SS Gambhir, L Tian, JK Willmann Thy1-Targeted Microbubbles for Ultrasound Molecular Imaging of Pancreatic Ductal Adenocarcinoma Clin. Cancer Res., 2018-01-04;0(0):. 2018-01-04 [PMID: 29301827] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse

Array 7335-CD

• CD90/Thy1 Antibodies
• CD90/Thy1 Proteins
• CD90/Thy1 Proteins and Enzymes