Recombinant Mouse CD43 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CD43, also known as Leukosialin, Sialophorin, B-cell differentiation antigen LP-3 and Ly-48, is a type I transmembrane sialylated mucin that is expressed on most leukocytes and some tumor cells (1). Notably, the membrane expression of CD43 seems to be a characteristic of leukocytes, while cytoplasmic expression without membrane insertion occurs in endothelium and select epithelia. While CD43 restricts leukocyte adhesion and modulates T cell activation, these activities are context specific (2). CD43 can both induce and protect against apoptosis, and can either promote or block cell adhesion (3). In mouse, CD43 is synthesized as a 395 amino acid (aa) precursor that contains a 19 aa signal sequence, a 229 aa extracellular region, a 23 aa TM domain, and a 124 aa cytoplasmic tail. The mouse extracellular region (aa 20-248) has only one N-linked glycosylation site while the human extracellular region (aa 20-253) has 25 O-linked glycosylation sites and one N-linked glycosylation site. Mouse CD43 extracellular region shares 38% and 61% aa sequence identity with the extracellular regions in human and rat CD43, respectively.

Array 9959-CD

• CD43/Sialophorin Antibodies
• CD43/Sialophorin Lysates
• CD43/Sialophorin Proteins
• CD43/Sialophorin Proteins and Enzymes