Recombinant Human IL-6 Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin-6 (IL-6) is a pleiotropic, alpha -helical, 22-28 kDa phosphorylated and variably glycosylated cytokine that plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression (1-5). Mature human IL-6 is 183 amino acids (aa) in length and shares 39% aa sequence identity with mouse and rat IL-6 (6). Alternative splicing generates several isoforms with internal deletions, some of which exhibit antagonistic properties (7-10). IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6 R alpha) and a signal transducing subunit (gp130). IL-6 binds to IL-6 R alpha , triggering IL-6 R alpha association with gp130 and gp130 dimerization (11). gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM (12). Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage (5). In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha (5). Trans-signaling enables a wider range of cell types to respond to IL-6, as the expression of gp130 is ubiquitous, while that of IL-6 R alpha is predominantly restricted to hepatocytes, monocytes, and resting lymphocytes (2, 5). Soluble splice forms of gp130 block trans-signaling from IL-6/IL-6 R alpha but not from other cytokines that use gp130 as a co-receptor (5, 13). IL-6, along with TNF-alpha and IL-1, drives the acute inflammatory response and the transition from acute inflammation to either acquired immunity or chronic inflammatory disease (1-5). When dysregulated, it contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis (1, 2, 5). IL-6 can also function as an anti-inflammatory molecule, as in skeletal muscle where it is secreted in response to exercise (2). In addition, it enhances hematopoietic stem cell proliferation and the differentiation of Th17 cells, memory B cells, and plasma cells (1, 14).

We have publications tested in 13 confirmed species: Human, Mouse, Rat, Bovine, Chicken, Hamster, N/A, Porcine, Primate - Chlorocebus pygerythrus (Vervet Monkey), Primate - Macaca mulatta (Rhesus Macaque), Primate - Pan troglodytes (Chimpanzee), Rabbit, Transgenic Mouse.

We have publications tested in 14 applications: Bioassay, Cell Culture, Control, Differentiation, ELISA (Standard), ELISA Capture, ELISA Control, ELISA Standard, IHC-P, In Vivo, Proximity Ligation Assay (PLA), Spheroid Culture, Stimulation, cell cutlure.

Showing Publications 1 - 10 of 364. Show All 364 Publications. Collapse Publications.

Publications using 206-IL	Applications	Species
Hong, J;Son, M;Sin, J;Kim, H;Chung, DK; Nanoparticles of Lactiplantibacillus plantarum K8 Reduce Staphylococcus aureus Respiratory Infection and Tumor Necrosis Factor Alpha- and Interferon Gamma-Induced Lung Inflammation Nutrients 2023-11-09 [PMID: 38004123] (ELISA Control, Human)	ELISA Control	Human
Urban, L;Novák, Š;?oma, M;Dvo?ánková, B;Lacina, L;Šáchová, J;Hradilová, M;Svato?ová, P;Kolá?, M;Strnad, H;B?ezinová, J;Smetana, K;Gál, P;Szabo, P; Unravelling heterogeneous effects of cancer?associated fibroblasts on poor prognosis markers in breast cancer EM?G3 cell line: In vitro?targeted treatment (anti?IL-6, anti?VEGF-A, anti?MFGE8) based on transcriptomic profiling Oncology reports 2024-01-01 [PMID: 37975220] (Bioassay, Human)	Bioassay	Human
Harmange, G;Hueros, RAR;Schaff, DL;Emert, B;Saint-Antoine, M;Kim, LC;Niu, Z;Nellore, S;Fane, ME;Alicea, GM;Weeraratna, AT;Simon, MC;Singh, A;Shaffer, SM; Disrupting cellular memory to overcome drug resistance Nature communications 2023-11-06 [PMID: 37932277] (Bioassay, Human)	Bioassay	Human
Zhang, X;Xu, X;Chen, J;Wang, G;Li, Q;Li, M;Lu, J; Identification of HHT-9041P1: A novel potent and selective JAK1 inhibitor in a rat model of rheumatoid arthritis International immunopharmacology 2023-10-24 [PMID: 37883818] (Bioassay, Human)	Bioassay	Human
Alimohammadi, S;Masuda-Kuroki, K;Szöll?si, AG;Di Nardo, A; Factors Influencing Marker Expressions of Cultured Human Cord Blood-Derived Mast Cells International journal of molecular sciences 2023-10-04 [PMID: 37834338] (Bioassay, Human)	Bioassay	Human
Rangel Rivera, GO;Dwyer, CJ;Knochelmann, HM;Smith, AS;Aksoy, BA;Cole, AC;Wyatt, MM;Kumaresan, S;Thaxton, JE;Lesinski, GB;Paulos, CM; Progressively enhancing stemness of adoptively transferred T cells with PI3K? blockade improves metabolism and anti-tumor immunity Cancer research 2023-10-06 [PMID: 37801615] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
Odell, ID;Agrawal, K;Sefik, E;Odell, AV;Caves, E;Kirkiles-Smith, NC;Horsley, V;Hinchcliff, M;Pober, JS;Kluger, Y;Flavell, RA; IL-6 trans-signaling in a humanized mouse model of scleroderma Proceedings of the National Academy of Sciences of the United States of America 2023-09-12 [PMID: 37669366] (Bioassay, Human)	Bioassay	Human
Twarog, M;Schustak, J;Xu, Y;Coble, M;Dolan, K;Esterberg, R;Huang, Q;Saint-Geniez, M;Bao, Y; TNF? induced by DNA-sensing in macrophage compromises retinal pigment epithelial (RPE) barrier function Scientific reports 2023-09-02 [PMID: 37660150] (Bioassay, Human)	Bioassay	Human
Vaikunthanathan, T;Landmann, E;Correa, DM;Romano, M;Trevelin, SC;Peng, Q;Crespo, E;Corrado, M;Lozano, JJ;Pearce, EL;Perpinan, E;Zoccarato, A;Siew, L;Edwards-Hicks, J;Khan, R;Luu, NT;Thursz, MR;Newsome, PN;Martinez-Llordella, M;Shah, N;Lechler, RI;Shah, AM;Sanchez-Fueyo, A;Lombardi, G;Safinia, N; Dysregulated anti-oxidant signalling and compromised mitochondrial integrity negatively influence regulatory T cell function and viability in liver disease EBioMedicine 2023-08-30 [PMID: 37657135] (Bioassay, Human)	Bioassay	Human
Lee, H;Xie, T;Yu, X;Schaffter, SW;Schulman, R; Plug-and-play protein biosensors using aptamer-regulated in vitro transcription bioRxiv : the preprint server for biology 2023-08-14 [PMID: 37645783] (Bioassay, Human)	Bioassay	Human
Newman, S;Wilson, B;Mamerow, D;Wollant, B;Nyein, H;Rosenberg-Hasson, Y;Maecker, H;Eisenstein, M;Soh, H; Extending the dynamic range of biomarker quantification through molecular equalization bioRxiv 2023-01-01 [PMID: 37443317] (Bioassay, Human)	Bioassay	Human
A Di Nardo, YL Chang, S Alimohamma, K Masuda-Kur, Z Wang, K Sriram, PA Insel Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts Cell Reports, 2023-04-28;42(5):112453. 2023-04-28 [PMID: 37120813] (Bioassay, Human)	Bioassay	Human
L Feige, T Kozaki, G Dias de Me, V Guillemot, F Larrous, F Ginhoux, H Bourhy Susceptibilities of CNS Cells towards Rabies Virus Infection Is Linked to Cellular Innate Immune Responses Viruses, 2022-12-29;15(1):. 2022-12-29 [PMID: 36680128] (Bioassay, Human)	Bioassay	Human
Y Fukawa, K Kayamori, M Tsuchiya, T Ikeda IL-1 Generated by Oral Squamous Cell Carcinoma Stimulates Tumor-Induced and RANKL-Induced Osteoclastogenesis: A Possible Mechanism of Bone Resorption Induced by the Infiltration of Oral Squamous Cell Carcinoma International Journal of Molecular Sciences, 2022-12-30;24(1):. 2022-12-30 [PMID: 36614130] (Cell Culture, Mouse)	Cell Culture	Mouse
MS Ågren, T Litman, JO Eriksen, P Schjerling, M Bzorek, LMR Gjerdrum Gene Expression Linked to Reepithelialization of Human Skin Wounds International Journal of Molecular Sciences, 2022-12-12;23(24):. 2022-12-12 [PMID: 36555389] (cell cutlure, Human)	cell cutlure	Human
X Liu, N Sato, T Yabushita, J Li, Y Jia, M Tamura, S Asada, T Fujino, T Fukushima, T Yonezawa, Y Tanaka, T Fukuyama, A Tsuchiya, S Shikata, H Iwamura, C Kinouchi, K Komatsu, S Yamasaki, T Shibata, AT Sasaki, J Schibler, M Wunderlich, E O'Brien, B Mizukawa, JC Mulloy, Y Sugiura, H Takizawa, T Shibata, K Miyake, T Kitamura, S Goyama IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia Embo Molecular Medicine, 2022-12-01;0(0):e15631. 2022-12-01 [PMID: 36453131] (Cell Culture, Human)	Cell Culture	Human
Kunitomi A, Hirohata R, Arreola V, Osawa M, Kato T, Nomura M, Kawaguchi J, Hara H, Kusano K, Takashima Y, Takahashi K, Fukuda K, Takasu N, Yamanaka S Improved Sendai viral system for reprogramming to naive pluripotency. Cell Rep Methods, 2022-10-17;2(11):100317. 2022-10-17 [PMID: 36447645] (Bioassay, Human)	Bioassay	Human
M Tayyab, P Xie, MA Sami, H Raji, Z Lin, Z Meng, SR Mahmoodi, M Javanmard A portable analog front-end system for label-free sensing of proteins using nanowell array impedance sensors Scientific Reports, 2022-11-22;12(1):20119. 2022-11-22 [PMID: 36418852] (ELISA Standard, Human)	ELISA Standard	Human
AKO Rode, TB Buus, V Mraz, FAH Al-Jaberi, DV Lopez, SL Ford, S Hennen, IP Eliasen, IV Klewe, L Gharehdagh, A Dragan, MM Rosenkilde, A Woetmann, L Skov, N Ødum, CM Bonefeld, M Kongsbak-W, C Geisler Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor Cells, 2022-08-19;11(16):. 2022-08-19 [PMID: 36010663] (Stimulation, Human)	Stimulation	Human
YS Michaels, JM Edgar, MC Major, EL Castle, C Zimmerman, T Yin, A Hagner, C Lau, HH Hsu, MI Ibañez-Rio, LJ Durland, DJHF Knapp, PW Zandstra DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells Science Advances, 2022-08-24;8(34):eabn5522. 2022-08-24 [PMID: 36001668] (Bioassay, Human)	Bioassay	Human
MY Wang, CM Zhang, HH Zhou, ZB Ge, CC Su, ZH Lou, XY Zhang, TT Xu, SY Li, L Zhu, YL Zhou, Y Wu, SR Ji Identification of a distal enhancer that determines the expression pattern of acute phase marker C-reactive protein Oncogene, 2022-06-17;0(0):102160. 2022-06-17 [PMID: 35724961] (Bioassay, Human)	Bioassay	Human
P Sekhri, DK Ledezma, A Shukla, EE Sweeney, R Fernandes The Thermal Dose of Photothermal Therapy Generates Differential Immunogenicity in Human Neuroblastoma Cells Cancers, 2022-03-11;14(6):. 2022-03-11 [PMID: 35326601] (Cell Culture, Human)	Cell Culture	Human
A Dritsoula, L Dowsett, C Pilotti, MN O'Connor, SE Moss, J Greenwood Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway Scientific Reports, 2022-03-22;12(1):4867. 2022-03-22 [PMID: 35318338] (Bioassay, Human)	Bioassay	Human
J Whitburn, SR Rao, EV Morris, S Tabata, A Hirayama, T Soga, JR Edwards, Z Kaya, C Palmer, FC Hamdy, CM Edwards Metabolic profiling of prostate cancer in skeletal microenvironments identifies G6PD as a key mediator of growth and survival Science Advances, 2022-02-25;8(8):eabf9096. 2022-02-25 [PMID: 35213227] (Bioassay, Human)	Bioassay	Human
T Matsumoto, H Okayama, S Nakajima, K Saito, M Ito, A Kaneta, Y Kanke, H Onozawa, S Hayase, S Fujita, W Sakamoto, M Saito, Z Seze, T Momma, K Mimura, K Kono SH2D4A downregulation due to loss of chromosome 8p is associated with poor prognosis and low T cell infiltration in colorectal cancer British Journal of Cancer, 2021-12-10;0(0):. 2021-12-10 [PMID: 34893760] (Bioassay, Human)	Bioassay	Human
SA Saenz, A Local, T Carr, A Shakya, S Koul, H Hu, L Chourb, J Stedman, J Malley, LA D'Agostino, V Shanmugasu, J Malona, CE Schwartz, L Beebe, M Clements, G Rajaraman, J Cho, L Jiang, A Dubrovskiy, M Kreilein, R Shimanovic, LG Hamann, L Escoubet, JM Ellis Small molecule allosteric inhibitors of RORgammat block Th17-dependent inflammation and associated gene expression in vivo PLoS ONE, 2021-11-09;16(11):e0248034. 2021-11-09 [PMID: 34752458] (Bioassay, Human)	Bioassay	Human
A Pirosa, EB Tankus, A Mainardi, P Occhetta, L Dönges, C Baum, M Rasponi, I Martin, A Barbero Modeling In Vitro Osteoarthritis Phenotypes in a Vascularized Bone Model Based on a Bone-Marrow Derived Mesenchymal Cell Line and Endothelial Cells International Journal of Molecular Sciences, 2021-09-03;22(17):. 2021-09-03 [PMID: 34502489] (Bioassay, Human)	Bioassay	Human
G Carbotti, B Dozin, S Martini, C Giordano, F Scordamagl, M Croce, G Filaci, S Ferrini, M Fabbi IL-27 Mediates PD-L1 Expression and Release by Human Mesothelioma Cells Cancers, 2021-08-09;13(16):. 2021-08-09 [PMID: 34439164] (Bioassay, Human)	Bioassay	Human
AL Fisher, V Sangkhae, K Balušíková, NJ Palaskas, T Ganz, E Nemeth Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy Nature Communications, 2021-06-29;12(1):4026. 2021-06-29 [PMID: 34188052] (Bioassay, Human)	Bioassay	Human
LG Lima, S Ham, H Shin, EPZ Chai, ESH Lek, RJ Lobb, AF Müller, S Mathivanan, B Yeo, Y Choi, BS Parker, A Möller Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution Nature Communications, 2021-06-10;12(1):3543. 2021-06-10 [PMID: 34112803] (ELISA Capture, Human)	ELISA Capture	Human
P Gonzalez-M, M Romano, H Yan, R Deshmukh, J Papoin, L Oburoglu, M Daumur, AS Dumé, I Phadke, C Mongellaz, X Qu, PN Bories, M Fontenay, X An, V Dardalhon, M Sitbon, VS Zimmermann, PG Gallagher, S Tardito, L Blanc, N Mohandas, N Taylor, S Kinet An IDH1-vitamin C crosstalk drives human erythroid development by inhibiting pro-oxidant mitochondrial metabolism Cell Reports, 2021-02-02;34(5):108723. 2021-02-02 [PMID: 33535038] (Bioassay, Human)	Bioassay	Human
H Gunawardan, T Romero, N Yao, S Heidt, A Mulder, DA Elashoff, NM Valenzuela Tissue-specific endothelial cell heterogeneity contributes to unequal inflammatory responses Scientific Reports, 2021-01-21;11(1):1949. 2021-01-21 [PMID: 33479269] (Bioassay, Human)	Bioassay	Human
KW Zhang, D Wang, H Cai, MQ Cao, YY Zhang, PY Zhuang, J Shen IL?6 plays a crucial role in epithelial?mesenchymal transition and pro?metastasis induced by sorafenib in liver cancer Oncology reports, 2021-01-07;0(0):. 2021-01-07 [PMID: 33432366] (Bioassay, Human)	Bioassay	Human
J Dong, S Viswanatha, E Adami, BK Singh, SP Chothani, B Ng, WW Lim, J Zhou, M Tripathi, NSJ Ko, SG Shekeran, J Tan, SY Lim, M Wang, PM Lio, PM Yen, S Schafer, SA Cook, AA Widjaja Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH Nature Communications, 2021-01-04;12(1):66. 2021-01-04 [PMID: 33397952] (Bioassay, Human)	Bioassay	Human
A Dorronsoro, V Lang, I Ferrin, J Fernández-, L Zabaleta, E Pérez-Ruiz, P Sepúlveda, C Trigueros Intracellular role of IL-6 in mesenchymal stromal cell immunosuppression and proliferation Scientific Reports, 2020-12-14;10(1):21853. 2020-12-14 [PMID: 33318571] (Bioassay, Human)	Bioassay	Human
J Stebbing, G Sánchez Ni, M Falcone, S Youhanna, P Richardson, S Ottaviani, JX Shen, C Sommerauer, G Tiseo, L Ghiadoni, A Virdis, F Monzani, LR Rizos, F Forfori, A Avendaño-C, S De Marco, L Carrozzi, F Lena, PM Sánchez-Ju, LG Lacerenza, N Cesira, D Caldevilla, A Perrella, L Niccoli, LS Méndez, D Matarrese, D Goletti, YJ Tan, V Monteil, G Dranitsari, F Cantini, A Farcomeni, S Dutta, SK Burley, H Zhang, M Pistello, W Li, M Mas Romero, F Andrés Pre, RS Simón-Tale, R García-Mol, C Kutter, JH Felce, ZF Nizami, AG Miklosi, JM Penninger, F Menichetti, A Mirazimi, P Abizanda, VM Lauschke JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality Sci Adv, 2021-01-01;0(0):. 2021-01-01 [PMID: 33187978] (Spheroid Culture, Human)	Spheroid Culture	Human
L Gan, H Shen, X Li, Z Han, Y Jing, X Yang, M Wu, Y Xia Mesenchymal stem cells promote chemoresistance by activating autophagy in intrahepatic cholangiocarcinoma Oncol Rep, 2020-11-06;0(0):. 2020-11-06 [PMID: 33155663] (Cell Culture, Human)	Cell Culture	Human
SA Sheehan, KL Hamilton, EP Retzbach, P Balachandr, H Krishnan, P Leone, GS Goldberg Evidence that Maackia amurensis seed lectin (MASL) exerts pleiotropic actions on oral squamous cells to inhibit SARS-CoV-2 infection and COVID-19 disease progression Res Sq, 2020-10-23;0(0):. 2020-10-23 [PMID: 33106801] (Bioassay, Human)	Bioassay	Human
L Gorchs, S Ahmed, C Mayer, A Knauf, C Fernández, M Svensson, R Heuchel, E Rangelova, P Bergman, H Kaipe The vitamin D analogue calcipotriol promotes an anti-tumorigenic phenotype of human pancreatic CAFs but reduces T cell mediated immunity Sci Rep, 2020-10-15;10(1):17444. 2020-10-15 [PMID: 33060625] (Human)		Human
Q Zhang, Z Yang, Y Ni, H Bai, Q Han, Z Yi, X Yi, YL Agbana, Y Kuang, Y Zhu NF-&kappaB and pSTAT3 synergistically drive G6PD overexpression and facilitate sensitivity to G6PD inhibition in ccRCC Cancer Cell Int, 2020-10-06;20(0):483. 2020-10-06 [PMID: 33041664] (Bioassay, Human)	Bioassay	Human
M Kurte, AM Vega-Lette, P Luz-Crawfo, F Djouad, D Noël, M Khoury, F Carrión Time-dependent LPS exposure commands MSC immunoplasticity through TLR4 activation leading to opposite therapeutic outcome in EAE Stem Cell Res Ther, 2020-09-25;11(1):416. 2020-09-25 [PMID: 32988406] (Bioassay, Human)	Bioassay	Human
D Talwar, J Messens, TP Dick A role for annexin A2 in scaffolding the peroxiredoxin 2-STAT3 redox relay complex Nature Communications, 2020-09-09;11(1):4512. 2020-09-09 [PMID: 32908147] (Bioassay, Human)	Bioassay	Human
JY Hur, GR Frost, X Wu, C Crump, SJ Pan, E Wong, M Barros, T Li, P Nie, Y Zhai, JC Wang, J Tcw, L Guo, A McKenzie, C Ming, X Zhou, M Wang, Y Sagi, AE Renton, BT Esposito, Y Kim, KR Sadleir, I Trinh, RA Rissman, R Vassar, B Zhang, DS Johnson, E Masliah, P Greengard, A Goate, YM Li The innate immunity protein IFITM3 modulates &gamma-secretase in Alzheimer's disease Nature, 2020-09-02;0(0):. 2020-09-02 [PMID: 32879487] (Bioassay, Human)	Bioassay	Human
MY Hsieh, JJ Lin, SH Hsia, JL Huang, KW Yeh, KW Chang, WI Lee Diminished toll-like receptor response in febrile infection-related epilepsy syndrome (FIRES) Biomed J, 2020-05-29;0(0):. 2020-05-29 [PMID: 32651134] (Bioassay, Human)	Bioassay	Human
J Yan, SP Pandey, BJ Barnes, JR Turner, C Abraham T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation Cell Rep, 2020-06-30;31(13):107820. 2020-06-30 [PMID: 32610123] (Bioassay, Human)	Bioassay	Human
L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids Cell Stem Cell, 2020-06-19;27(1):125-136.e7. 2020-06-19 [PMID: 32579880] (Bioassay, Human)	Bioassay	Human
L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids Cell Stem Cell, 2020;27(1):125-136.e7. 2020 [PMID: 32579880] (Bioassay, Human)	Bioassay	Human
JL Spivak, A Merchant, DM Williams, O Rogers, W Zhao, A Duffield, LS Resar, AR Moliterno, ZJ Zhao Thrombopoietin is required for full phenotype expression in a JAK2V617F transgenic mouse model of polycythemia vera PLoS ONE, 2020-06-01;15(6):e0232801. 2020-06-01 [PMID: 32479500] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
MF Abas?yan?k, K Wolfe, H Van Phan, J Lin, B Laxman, SR White, PA Verhoef, GM Mutlu, B Patel, S Tay Ultrasensitive digital quantification of cytokines and bacteria predicts septic shock outcomes Nat Commun, 2020-05-25;11(1):2607. 2020-05-25 [PMID: 32451375] (Bioassay, Human)	Bioassay	Human
J Kanasugi, I Hanamura, A Ota, S Karnan, VQ Lam, S Mizuno, M Wahiduzzam, ML Rahman, T Hyodo, H Konishi, S Tsuzuki, Y Hosokawa, A Takami Biallelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells Cancer Sci., 2020-04-09;111(5):1663-1675. 2020-04-09 [PMID: 32176823] (Cell Culture, Human)	Cell Culture	Human
H Xiang, CP Ramil, J Hai, C Zhang, H Wang, AA Watkins, R Afshar, P Georgiev, MA Sze, XS Song, PJ Curran, M Cheng, JR Miller, D Sun, A Loboda, Y Jia, LY Moy, A Chi, PE Brandish Cancer-associated fibroblasts promote immunosuppression by inducing ROS-generating monocytic MDSCs in lung squamous cell carcinoma Cancer Immunol Res, 2020-02-19;0(0):. 2020-02-19 [PMID: 32075803] (Bioassay, Human)	Bioassay	Human
T Mang, S Lindemann, A Gigout Increasing the Medium Osmolarity Reduces the Inflammatory Status of Human OA Chondrocytes and Increases Their Responsiveness to GDF-5 Int J Mol Sci, 2020-01-14;21(2):. 2020-01-14 [PMID: 31947660] (Cell Culture, Human)	Cell Culture	Human
D Parashar, A Geethadevi, MR Aure, J Mishra, J George, C Chen, MK Mishra, A Tahiri, W Zhao, B Nair, Y Lu, LS Mangala, C Rodriguez-, G Lopez-Bere, AKS Camara, M Liang, JS Rader, R Ramchandra, M You, AK Sood, VN Kristensen, GB Mills, S Pradeep, P Chaluvally miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer Cell Rep, 2019-12-24;29(13):4389-4406.e10. 2019-12-24 [PMID: 31875548] (Cell Culture, Human)	Cell Culture	Human
JS Hook, M Cao, K Weng, N Kinnare, JG Moreland Mycobacterium tuberculosis Lipoarabinomannan Activates Human Neutrophils via a TLR2/1 Mechanism Distinct from Pam3CSK4 J. Immunol., 2019-12-23;0(0):. 2019-12-23 [PMID: 31871022] (ELISA Standard, Human)	ELISA Standard	Human
D De Silva, Z Zhang, Y Liu, JS Parker, C Xu, L Cai, GG Wang, HS Earp, YE Whang Interaction between androgen receptor and coregulator SLIRP is regulated by Ack1 tyrosine kinase and androgen Sci Rep, 2019-12-09;9(1):18637. 2019-12-09 [PMID: 31819114] (Cell Culture, Human)	Cell Culture	Human
X Sun, Q Qu, Y Lao, M Zhang, X Yin, H Zhu, Y Wang, J Yang, J Yi, M Hao Tumor suppressor HIC1 is synergistically compromised by cancer-associated fibroblasts and tumor cells through the IL-6/pSTAT3 axis in breast cancer BMC Cancer, 2019-12-03;19(1):1180. 2019-12-03 [PMID: 31795965] (ELISA Standard, Human)	ELISA Standard	Human
A Stumpf, T Brandstett, J Hübner, J Rühe Hydrogel based protein biochip for parallel detection of biomarkers for diagnosis of a Systemic Inflammatory Response Syndrome (SIRS) in human serum PLoS ONE, 2019-12-02;14(12):e0225525. 2019-12-02 [PMID: 31790441] (ELISA Standard, Human)	ELISA Standard	Human
X Xu, H Fukui, Y Ran, X Wang, Y Inoue, N Ebisudani, H Nishimura, T Tomita, T Oshima, J Watari, H Kiyama, H Miwa The Link between Type III Reg and STAT3-Associated Cytokines in Inflamed Colonic Tissues Mediators Inflamm., 2019-11-06;2019(0):7859460. 2019-11-06 [PMID: 31780871] (Bioassay, Human)	Bioassay	Human
N Uyama, H Tsutsui, S Wu, K Yasuda, E Hatano, XY Qin, S Kojima, J Fujimoto Anti-interleukin-6 receptor antibody treatment ameliorates postoperative adhesion formation Sci Rep, 2019-11-26;9(1):17558. 2019-11-26 [PMID: 31772282] (IHC-P, Human)	IHC-P	Human
JY Ko, WS Lian, TC Tsai, YS Chen, CK Hsieh, CW Kuo, FS Wang MicroRNA-29a Mitigates Subacromial Bursa Fibrosis in Rotator Cuff Lesion with Shoulder Stiffness Int J Mol Sci, 2019-11-15;20(22):. 2019-11-15 [PMID: 31731750] (Cell Culture, Human)	Cell Culture	Human
AT Stefka, D Johnson, S Rosebeck, JH Park, Y Nakamura, AJ Jakubowiak Potent anti-myeloma activity of the TOPK inhibitor OTS514 in pre-clinical models Cancer Med, 2019-11-12;0(0):. 2019-11-12 [PMID: 31714026] (Cell Culture, Human)	Cell Culture	Human
JE Lee, X Zhong, JY Lee, YJ Surh, HK Na 15-Keto prostaglandin E2 induces heme oxygenase-1 expression through activation of Nrf2 in human colon epithelial CCD 841 CoN cells Arch. Biochem. Biophys., 2019-12-24;0(0):108162. 2019-12-24 [PMID: 31669540] (Bioassay, Human)	Bioassay	Human
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M Suga, T Kondo, K Imamura, R Shibukawa, Y Okanishi, Y Sagara, K Tsukita, T Enami, M Furujo, K Saijo, Y Nakamura, M Osawa, MK Saito, S Yamanaka, H Inoue Generation of a human induced pluripotent stem cell line, BRCi001-A, derived from a patient with mucopolysaccharidosis type I Stem Cell Res, 2019-02-12;36(0):101406. 2019-02-12 [PMID: 30849633] (Bioassay, Human)	Bioassay	Human
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TA Ahmed, C Adamopoulo, Z Karoulia, X Wu, R Sachidanan, SA Aaronson, PI Poulikakos SHP2 Drives Adaptive Resistance to ERK Signaling Inhibition in Molecularly Defined Subsets of ERK-Dependent Tumors Cell Rep, 2019-01-02;26(1):65-78.e5. 2019-01-02 [PMID: 30605687] (Bioassay, Human)	Bioassay	Human
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U Painuly, V Ramakrishn, T Kimlinger, L Wellik, J Haug, W Gonsalves, L Bi, Z Huang, SV Rajkumar, S Kumar Aurora kinase and FGFR3 inhibition results in significant apoptosis in molecular subgroups of multiple myeloma Oncotarget, 2018-10-02;9(77):34582-34594. 2018-10-02 [PMID: 30349651] (Bioassay, Human)	Bioassay	Human
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X Jin, X He, X Cao, P Xu, Y Xing, S Sui, L Wang, J Meng, W Lu, R Cui, H Ni, M Zhao Iron overload impairs normal hematopoietic stem and progenitor cells through reactive oxygen species and shortens survival in myelodysplastic syndrome mice Haematologica, 2018-06-14;0(0):. 2018-06-14 [PMID: 29903757] (In Vivo, Mouse)	In Vivo	Mouse
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H Pei, L He, M Shao, Z Yang, Y Ran, D Li, Y Zhou, M Tang, T Wang, Y Gong, X Chen, S Yang, M Xiang, L Chen Discovery of a highly selective JAK3 inhibitor for the treatment of rheumatoid arthritis Sci Rep, 2018-03-27;8(1):5273. 2018-03-27 [PMID: 29588471] (Bioassay, Human)	Bioassay	Human
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H Alsaffar, N Martino, JP Garrett, AP Adam Interleukin-6 promotes a sustained loss of endothelial barrier function via Janus kinase-mediated STAT3 phosphorylation and de novo protein synthesis Am. J. Physiol., Cell Physiol., 2018-01-10;0(0):. 2018-01-10 [PMID: 29351406] (Bioassay, Human)	Bioassay	Human
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K Schmitt, P Charlins, M Veselinovi, L Kinner-Bib, S Hu, J Curlin, L Remling-Mu, KE Olson, T Aboellail, R Akkina Zika viral infection and neutralizing human antibody response in a BLT humanized mouse model Virology, 2018-01-06;515(0):235-242. 2018-01-06 [PMID: 29310105] (Bioassay, Human)	Bioassay	Human
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GE Tyzack, CE Hall, CR Sibley, T Cymes, S Forostyak, G Carlino, IF Meyer, G Schiavo, SC Zhang, GM Gibbons, J Newcombe, R Patani, A Lakatos A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models Nat Commun, 2017-10-27;8(1):1164. 2017-10-27 [PMID: 29079839] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
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D Wang, S Tang, Q Zhang Maslinic acid suppresses the growth of human gastric cells by inducing apoptosis via inhibition of the interleukin-6 mediated Janus kinase/signal transducer and activator of transcription 3 signaling pathway Oncol Lett, 2017-04-21;13(6):4875-4881. 2017-04-21 [PMID: 28599489] (Bioassay, Human)	Bioassay	Human
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Y Kokubu, T Yamaguchi, K Kawabata In�vitro model of cerebral ischemia by using brain microvascular endothelial cells derived from human induced pluripotent stem cells Biochem. Biophys. Res. Commun, 2017-03-21;0(0):. 2017-03-21 [PMID: 28336435] (Bioassay, Human)	Bioassay	Human
JA Schwartz, KL Clayton, S Mujib, H Zhang, AK Rahman, J Liu, FY Yue, E Benko, C Kovacs, MA Ostrowski Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9 J. Immunol, 2017-03-06;0(0):. 2017-03-06 [PMID: 28264968] (Bioassay, Human)	Bioassay	Human
H He, AE Kuriyan, CW Su, M Mahabole, Y Zhang, YT Zhu, HW Flynn, JM Parel, SC Tseng Inhibition of Proliferation and Epithelial Mesenchymal Transition in Retinal Pigment Epithelial Cells by Heavy Chain-Hyaluronan/Pentraxin 3 Sci Rep, 2017-03-02;7(0):43736. 2017-03-02 [PMID: 28252047] (Bioassay, Human)	Bioassay	Human
AS Pachori, M Madan, YO Nunez Lope, F Yi, C Meyer, AA Seyhan Reduced skeletal muscle secreted frizzled-related protein 3 is associated with inflammation and insulin resistance Obesity (Silver Spring), 2017-02-27;0(0):. 2017-02-27 [PMID: 28240822] (Bioassay, Human)	Bioassay	Human
H Tsukamoto, K Fujieda, M Hirayama, T Ikeda, A Yuno, K Matsumura, D Fukuma, K Araki, H Mizuta, H Nakayama, S Senju, Y Nishimura Soluble IL-6R expressed by myeloid cells reduces tumor-specific Th1 differentation and drives tumor progression Cancer Res, 2017-02-24;0(0):. 2017-02-24 [PMID: 28235765] (Bioassay, Human)	Bioassay	Human
JS Muhammad, S Nanjo, T Ando, S Yamashita, T Maekita, T Ushijima, Y Tabuchi, T Sugiyama Autophagy Impairment by Helicobacter pylori-induced Methylation Silencing of MAP1LC3Av1 Promotes Gastric Carcinogenesis Int. J. Cancer, 2017-03-14;0(0):. 2017-03-14 [PMID: 28214334] (Bioassay, Rat)	Bioassay	Rat
M Tanaka, H Tashiro, B Omer, N Lapteva, J Ando, M Ngo, B Mehta, G Dotti, PR Kinchingto, AM Leen, C Rossig, CM Rooney Vaccination targeting native receptors to enhance the function and proliferation of chimeric antigen receptor (CAR)-modified T cells Clin. Cancer Res, 2017-02-09;0(0):. 2017-02-09 [PMID: 28183713] (Bioassay, Mouse)	Bioassay	Mouse
C Lin, W Liao, Y Jian, Y Peng, X Zhang, L Ye, Y Cui, B Wang, X Wu, Z Xiong, S Wu, J Li, X Wang, L Song CGI-99 promotes breast cancer metastasis via autocrine interleukin-6 signaling Oncogene, 2017-02-06;0(0):. 2017-02-06 [PMID: 28166202] (Bioassay, Human)	Bioassay	Human
A Bott, N Erdem, S Lerrer, A Hotz-Wagen, C Breunig, K Abnaof, A Wörner, H Wilhelm, E Münsterman, A Ben-Baruch, S Wiemann miRNA-1246 induces pro-inflammatory responses in mesenchymal stem/stromal cells by regulating PKA and PP2A Oncotarget, 2017-07-04;8(27):43897-43914. 2017-07-04 [PMID: 28159925] (Bioassay, Human)	Bioassay	Human
R Adams, RJ Burnley, CR Valenzano, O Qureshi, C Doyle, S Lumb, M Del Carmen, R Griffin, D McMillan, RD Taylor, C Meier, P Mori, LM Griffin, U Wernery, J Kinne, S Rapecki, TS Baker, AD Lawson, M Wright, A Ettorre Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling Sci Rep, 2017-01-30;7(0):37716. 2017-01-30 [PMID: 28134246] (Bioassay, Human)	Bioassay	Human
KZ Oben, BW Gachuki, SS Alhakeem, MK McKenna, Y Liang, DK St Clair, VM Rangnekar, S Bondada Radiation Induced Apoptosis of Murine Bone Marrow Cells Is Independent of Early Growth Response 1 (EGR1) PLoS ONE, 2017-01-12;12(1):e0169767. 2017-01-12 [PMID: 28081176] (Bioassay, Mouse)	Bioassay	Mouse
Elias S, Schmidt A, Kannan V, Andersson J, Tegner J TGF-beta Affects the Differentiation of Human GM-CSF+ CD4+ T Cells in an Activation- and Sodium-Dependent Manner. Front Immunol, 2016-12-23;7(0):603. 2016-12-23 [PMID: 28066414] (Bioassay, Human)	Bioassay	Human
L J Spicer G protein-coupled receptor 34 in ovarian granulosa cells of cattle: changes during follicular development and potential functional implications Domest. Anim. Endocrinol, 2016-12-11;59(0):90-99. 2016-12-11 [PMID: 28040605] (Bioassay, Bovine)	Bioassay	Bovine
Anja Kerstein Environmental factor and inflammation-driven alteration of the total peripheral T-cell compartment in granulomatosis with polyangiitis J. Autoimmun, 2016-12-28;0(0):. 2016-12-28 [PMID: 28040323] (Bioassay, Human)	Bioassay	Human
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Yukio Takeshita Effects of neuromyelitis optica-IgG at the blood-brain barrier in vitro Neurol Neuroimmunol Neuroinflamm, 2016-12-19;4(1):e311. 2016-12-19 [PMID: 28018943] (Bioassay, Human)	Bioassay	Human
Aurélie Chiche Injury-Induced Senescence Enables In�Vivo Reprogramming in Skeletal Muscle Cell Stem Cell, 2016-12-22;0(0):. 2016-12-22 [PMID: 28017795] (Bioassay, Human)	Bioassay	Human
Structure-based virtual screening and characterization of a novel IL-6 antagonistic compound from synthetic compound database Drug Des Devel Ther, 2016-12-15;10(0):4091-4100. 2016-12-15 [PMID: 28008232] (Bioassay, Human)	Bioassay	Human
Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia Oncogene, 2016-12-19;0(0):. 2016-12-19 [PMID: 27991934] (Bioassay, Human)	Bioassay	Human
Macrophages Enhance Migration in Inflammatory Breast Cancer Cells via RhoC GTPase Signaling Sci Rep, 2016-12-19;6(0):39190. 2016-12-19 [PMID: 27991524] (Bioassay, Human)	Bioassay	Human
Rajeev K Tyagi A generic RNA pulsed DC based approach for developing therapeutic intervention against Nasopharyngeal Carcinoma Hum Vaccin Immunother, 2016-11-30;0(0):0. 2016-11-30 [PMID: 27901642] (Bioassay, Human)	Bioassay	Human
Andrea Todisco Regulation and function of Bone Morphogenetic Protein signaling in colonic injury and inflammation Am. J. Physiol. Gastrointest. Liver Physiol., 2016-11-17;0(0):ajpgi.00169.2. 2016-11-17 [PMID: 27856416] (Bioassay, Human)	Bioassay	Human
Robert Sabat MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations Mediators Inflamm., 2016-10-23;2016(0):4097574. 2016-10-23 [PMID: 27843200] (Bioassay, Human)	Bioassay	Human
Derek N J Hart The Analysis of CD83 Expression on Human Immune Cells Identifies a Unique CD83+-Activated T Cell Population J. Immunol., 2016-11-11;0(0):. 2016-11-11 [PMID: 27837105] (Bioassay, Human)	Bioassay	Human
Angela P Bastidas-C, Astrid D Bakker, Behrouz Zandieh-D, Cornelis J Kleverlaa, Nathalie Bravenboe, Tim Forouzanf, Jenneke Klein-Nul Cytokines TNF-?, IL-6, IL-17F, and IL-4 Differentially Affect Osteogenic Differentiation of Human Adipose Stem Cells. Stem Cells International, 2016-09-07;0(0):1687-966X. 2016-09-07 [PMID: 27667999] (Bioassay, Human)	Bioassay	Human
Activated monocytes resist elimination by retinal pigment epithelium and downregulate their OTX2 expression via TNF-? Aging Cell, 2016-09-22;0(0):. 2016-09-22 [PMID: 27660103] (Bioassay, Porcine)	Bioassay	Porcine
Involvement of Spinal IL-6 Trans-Signaling in the Induction of Hyperexcitability of Deep Dorsal Horn Neurons by Spinal Tumor Necrosis Factor-Alpha J Neurosci, 2016-09-21;36(38):9782-91. 2016-09-21 [PMID: 27656018] (Bioassay, Rat)	Bioassay	Rat
Endothelial Cell Activation is Regulated by Epidermal Growth Factor-Like Domain 7 (Egfl7) during Inflammation J Biol Chem, 2016-09-20;0(0):. 2016-09-20 [PMID: 27650497] (Bioassay, Human)	Bioassay	Human
Signaling and Immunoresolving Actions of Resolvin D1 in Inflamed Human Visceral Adipose Tissue J Immunol, 2016-09-19;0(0):. 2016-09-19 [PMID: 27647830] (Bioassay, Human)	Bioassay	Human
Regulation of Polycystin-1 Function by Calmodulin Binding PLoS ONE, 2016-08-25;11(8):e0161525. 2016-08-25 [PMID: 27560828] (Bioassay, Human)	Bioassay	Human
Jak1-STAT3 signals are essential effectors of the USP6/TRE17 oncogene in tumorigenesis Cancer Res, 2016-07-20;0(0):. 2016-07-20 [PMID: 27440725] (Bioassay, Mouse)	Bioassay	Mouse
Olaf Pinkenburg The Human Antimicrobial Protein Bactericidal/Permeability-Increasing Protein (BPI) Inhibits the Infectivity of Influenza A Virus PLoS ONE, 2016-06-06;11(6):e0156929. 2016-06-06 [PMID: 27273104] (ELISA (Standard), Human)	ELISA (Standard)	Human
Marcin Ratajewski Expression of human gene coding ROR?T receptor depends on the Sp2 transcription factor J Leukoc Biol, 2016-06-02;0(0):. 2016-06-02 [PMID: 27256574] (Bioassay, Human)	Bioassay	Human
MM Halpert, V Konduri, D Liang, Y Chen, JB Wing, S Paust, JM Levitt, WK Decker Dendritic Cell-Secreted Cytotoxic T-Lymphocyte-Associated Protein-4 Regulates the T-cell Response by Downmodulating Bystander Surface B7 Stem Cells Dev., 2016-05-02;25(10):774-87. 2016-05-02 [PMID: 26979751] (Bioassay, Human)	Bioassay	Human
Zhong H, Davis A, Ouzounova M, Carrasco R, Chen C, Breen S, Chang Y, Huang J, Liu Z, Yao Y, Hurt E, Moisan J, Fung M, Tice D, Clouthier S, Xiao Z, Wicha M, Korkaya H, Hollingsworth R A Novel IL6 Antibody Sensitizes Multiple Tumor Types to Chemotherapy Including Trastuzumab-Resistant Tumors. Cancer Res, 2016-01-07;76(2):480-90. 2016-01-07 [PMID: 26744529] (Bioassay, Human)	Bioassay	Human
Huston S, Ngamskulrungroj P, Xiang R, Ogbomo H, Stack D, Li S, Timm-McCann M, Kyei S, Oykhman P, Kwon-Chung K, Mody C Cryptococcus gattii Capsule Blocks Surface Recognition Required for Dendritic Cell Maturation Independent of Internalization and Antigen Processing. J Immunol, 2016-01-06;196(3):1259-71. 2016-01-06 [PMID: 26740109] (Bioassay, Human)	Bioassay	Human
BR Yoon, YH Chung, SJ Yoo, K Kawara, J Kim, IS Yoo, CG Park, SW Kang, WW Lee Preferential Induction of the T Cell Auxiliary Signaling Molecule B7-H3 on Synovial Monocytes in Rheumatoid Arthritis J. Biol. Chem, 2015-12-23;291(8):4048-57. 2015-12-23 [PMID: 26702052] (Bioassay, Human)	Bioassay	Human
Min H, Kim S, Baek S, Woo J, Park J, Cho M, Lee J, Kwok S, Kim S, Park S Anthocyanin Extracted from Black Soybean Seed Coats Prevents Autoimmune Arthritis by Suppressing the Development of Th17 Cells and Synthesis of Proinflammatory Cytokines by Such Cells, via Inhibition of NF-kappaB. PLoS ONE, 2015-11-06;10(11):e0138201. 2015-11-06 [PMID: 26544846] (Bioassay, Mouse)	Bioassay	Mouse
Dong B, Shi Z, Wang J, Wu J, Yang Z, Fang K IL-6 Inhibits the Targeted Modulation of PDCD4 by miR-21 in Prostate Cancer. PLoS ONE, 2015-08-07;10(8):e0134366. 2015-08-07 [PMID: 26252635] (Bioassay, Human)	Bioassay	Human
Yousef S, Heise J, Lajmi N, Bartels K, Kroger N, Luetkens T, Atanackovic D Cancer-testis antigen SLLP1 represents a promising target for the immunotherapy of multiple myeloma. J Transl Med, 2015-06-20;13(0):197. 2015-06-20 [PMID: 26088750] (Bioassay, Human)	Bioassay	Human
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Hong S, Choi J, Lee S, Park Y, Park K, Lee J, Kim J, Gajulapati V, Goo J, Singh S, Lee K, Kim Y, Im S, Ahn S, Rose-John S, Heo T, Choi Y A Novel Small-Molecule Inhibitor Targeting the IL-6 Receptor beta Subunit, Glycoprotein 130. J Immunol, 2015-05-29;195(1):237-45. 2015-05-29 [PMID: 26026064] (Bioassay, Human)	Bioassay	Human
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James B Canavan Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease Gut, 2015-02-24;65(4):584-94. 2015-02-24 [PMID: 25715355] (Bioassay, Human)	Bioassay	Human
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Lee D, Sung K, Bartlett D, Kwon Y, Lee Y HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells. Cell Signal, 2014-11-18;27(2):293-305. 2014-11-18 [PMID: 25446253] (Bioassay, Human)	Bioassay	Human
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Melemedjian O, Tillu D, Moy J, Asiedu M, Mandell E, Ghosh S, Dussor G, Price T Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity. Mol Pain, 2014-07-04;10(0):45. 2014-07-04 [PMID: 24993495] (Bioassay, In Vivo, Mouse)	Bioassay, In Vivo	Mouse
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Kastrati I, Canestrari E, Frasor J PHLDA1 expression is controlled by an estrogen receptor-NFkappaB-miR-181 regulatory loop and is essential for formation of ER+ mammospheres. Oncogene, 2014-06-23;34(18):2309-16. 2014-06-23 [PMID: 24954507] (Bioassay, Human)	Bioassay	Human
Tanaka , Akinobu, Zhu , Qinchang, Tan , Hui, Horiba , Hiroki, Ohnuki , Koichiro, Mori , Yasuhiro, Yamauchi , Ryoko, Ishikawa , Hiroya, Iwamoto , Akira, Kawahara , Hiroharu, Shimizu , Kuniyosh Biological activities and phytochemical profiles of extracts from different parts of bamboo (Phyllostachys pubescens). Molecules, 2014-06-18;19(6):8238-60. 2014-06-18 [PMID: 24945578] (Bioassay, Human)	Bioassay	Human
Bettini M, Blanchfield L, Castellaw A, Zhang Q, Nakayama M, Smeltzer M, Zhang H, Hogquist K, Evavold B, Vignali D TCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential. J Immunol, 2014-06-18;193(2):571-9. 2014-06-18 [PMID: 24943217] (Bioassay, Mouse)	Bioassay	Mouse
Mimura N, Hideshima T, Shimomura T, Suzuki R, Ohguchi H, Rizq O, Kikuchi S, Yoshida Y, Cottini F, Jakubikova J, Cirstea D, Gorgun G, Minami J, Tai Y, Richardson P, Utsugi T, Iwama A, Anderson K Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition. Cancer Res, 2014-06-16;74(16):4458-69. 2014-06-16 [PMID: 24934808] (Bioassay, Human)	Bioassay	Human
Linher-Melville , Katja, Singh , Gurmit The transcriptional responsiveness of LKB1 to STAT-mediated signaling is differentially modulated by prolactin in human breast cancer cells. BMC Cancer, 2014-06-09;14(0):415. 2014-06-09 [PMID: 24913037] (Bioassay, Human)	Bioassay	Human
Horwitz , Mitchell, Chao , Nelson J, Rizzieri , David A, Long , Gwynn D, Sullivan , Keith M, Gasparetto , Cristina, Chute , John P, Morris , Ashley, McDonald , Carolyn, Waters-Pick , Barbara, Stiff , Patrick, Wease , Steven, Peled , Amnon, Snyder , David, Cohen , Einat Ga, Shoham , Hadas, Landau , Efrat, Friend , Etty, Peleg , Iddo, Aschengrau , Dorit, Yackoubov , Dima, Kurtzberg , Joanne, Peled , Tony Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment. J Clin Invest, 2014-06-09;124(7):3121-8. 2014-06-09 [PMID: 24911148] (Bioassay, Human)	Bioassay	Human
Volpe E, Pattarini L, Martinez-Cingolani C, Meller S, Donnadieu M, Bogiatzi S, Fernandez M, Touzot M, Bichet J, Reyal F, Paronetto M, Chiricozzi A, Chimenti S, Nasorri F, Cavani A, Kislat A, Homey B, Soumelis V Thymic stromal lymphopoietin links keratinocytes and dendritic cell-derived IL-23 in patients with psoriasis. J Allergy Clin Immunol, 2014-06-06;134(2):373-81. 2014-06-06 [PMID: 24910175] (Bioassay, Human)	Bioassay	Human
Zhao Y, Xiao X, Frank S, Lin H, Xia Y Distinct mechanisms of induction of hepatic growth hormone resistance by endogenous IL-6, TNF-alpha, and IL-1beta. Am J Physiol Endocrinol Metab, 2014-06-03;307(2):E186-98. 2014-06-03 [PMID: 24895283] (Bioassay, Human)	Bioassay	Human
Kofler D, Marson A, Dominguez-Villar M, Xiao S, Kuchroo V, Hafler D Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells. J Clin Invest, 2014-05-08;124(6):2513-22. 2014-05-08 [PMID: 24812667] (Bioassay, Human)	Bioassay	Human
Kongsbak M, von Essen M, Boding L, Levring T, Schjerling P, Lauritsen J, Woetmann A, Odum N, Bonefeld C, Geisler C Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells. PLoS ONE, 2014-05-02;9(5):e96695. 2014-05-02 [PMID: 24792400] (Bioassay, Human)	Bioassay	Human
Bu Y, Su F, Wang X, Gao H, Lei L, Chang N, Wu Q, Hu K, Zhu X, Chang Z, Meng K, Xiong J Protein tyrosine phosphatase PTPN9 regulates erythroid cell development through STAT3 dephosphorylation in zebrafish. J Cell Sci, 2014-04-11;127(0):2761-70. 2014-04-11 [PMID: 24727614] (Bioassay, Human)	Bioassay	Human
Richter R, Jochheim-Richter A, Ciuculescu F, Kollar K, Seifried E, Forssmann U, Verzijl D, Smit M, Blanchet X, von Hundelshausen P, Weber C, Forssmann W, Henschler R Identification and characterization of circulating variants of CXCL12 from human plasma: effects on chemotaxis and mobilization of hematopoietic stem and progenitor cells. Stem Cells Dev, 2014-05-27;23(16):1959-74. 2014-05-27 [PMID: 24708339] (Bioassay, Mouse)	Bioassay	Mouse
Zheng Y, Chow S, Boernert K, Basel D, Mikuscheva A, Kim S, Fong-Yee C, Trivedi T, Buttgereit F, Sutherland R, Dunstan C, Zhou H, Seibel M Direct crosstalk between cancer and osteoblast lineage cells fuels metastatic growth in bone via auto-amplification of IL-6 and RANKL signaling pathways. J Bone Miner Res, 2014-09-01;29(9):1938-49. 2014-09-01 [PMID: 24676805] (Bioassay, Human)	Bioassay	Human
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Umashankar , Mahadeva, Rak , Michael, Bughio , Farah, Zagallo , Patricia, Caviness , Katie, Goodrum , Felicia Antagonistic determinants controlling replicative and latent states of human cytomegalovirus infection. J Virol, 2014-03-12;88(11):5987-6002. 2014-03-12 [PMID: 24623432] (Bioassay, Human)	Bioassay	Human
Pei X, Dai Y, Felthousen J, Chen S, Takabatake Y, Zhou L, Youssefian L, Sanderson M, Bodie W, Kramer L, Orlowski R, Grant S Circumvention of Mcl-1-dependent drug resistance by simultaneous Chk1 and MEK1/2 inhibition in human multiple myeloma cells. PLoS ONE, 2014-03-04;9(3):e89064. 2014-03-04 [PMID: 24594907] (Bioassay, Human)	Bioassay	Human
Di Martino M, Gulla A, Gallo Cantafio M, Altomare E, Amodio N, Leone E, Morelli E, Lio S, Caracciolo D, Rossi M, Frandsen N, Tagliaferri P, Tassone P In vitro and in vivo activity of a novel locked nucleic acid (LNA)-inhibitor-miR-221 against multiple myeloma cells. PLoS ONE, 2014-02-21;9(2):e89659. 2014-02-21 [PMID: 24586944] (Bioassay, Human)	Bioassay	Human
Liu R, Zeng Y, Lei Z, Wang L, Yang H, Liu Z, Zhao J, Zhang H JAK/STAT3 signaling is required for TGF-beta-induced epithelial-mesenchymal transition in lung cancer cells. Int J Oncol, 2014-02-21;44(5):1643-51. 2014-02-21 [PMID: 24573038] (Bioassay, Human)	Bioassay	Human
O'Reilly S, Ciechomska M, Cant R, van Laar J Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-beta (TGF-beta) signaling promoting SMAD3 activation and fibrosis via Gremlin protein. J Biol Chem, 2014-02-18;289(14):9952-60. 2014-02-18 [PMID: 24550394] (Bioassay, Human)	Bioassay	Human
Prigent L, Robineau M, Jouneau S, Morzadec C, Louarn L, Vernhet L, Fardel O, Sparfel L The aryl hydrocarbon receptor is functionally upregulated early in the course ofvhuman T-cell activation. Eur J Immunol, 2014-02-18;44(5):1330-40. 2014-02-18 [PMID: 24549985] (Bioassay, Human)	Bioassay	Human
Valle Oseguera , Cendy A, Spencer , Juliet V cmvIL-10 stimulates the invasive potential of MDA-MB-231 breast cancer cells. PLoS ONE, 2014-02-10;9(2):e88708. 2014-02-10 [PMID: 24520416] (Bioassay, Human)	Bioassay	Human
Milwid , Jack M, Elman , Jessica, Li , Matthew, Shen , Keyue, Manrai , Arjun, Gabow , Aaron, Yarmush , Joshua, Jiao , Yunxin, Fletcher , Anne, Lee , Jungwoo, Cima , Michael, Yarmush , Martin L, Parekkadan , Biju Enriched protein screening of human bone marrow mesenchymal stromal cell secretions reveals MFAP5 and PENK as novel IL-10 modulators. Mol Ther, 2014-02-05;22(5):999-1007. 2014-02-05 [PMID: 24496384] (Bioassay, Human)	Bioassay	Human
Jensen B, Frandsen P, Raaby E, Schiotz P, Skov P, Poulsen L Molecular and stimulus-response profiles illustrate heterogeneity between peripheral and cord blood-derived human mast cells. J Leukoc Biol, 2014-02-03;95(6):893-901. 2014-02-03 [PMID: 24493825] (Bioassay, Human)	Bioassay	Human
McCutcheon , Krista M, Gray , Julia, Chen , Natalie, Liu , Keyi, Park , Minha, Ellsworth , Stote, Tripp , Ralph A, Tompkins , S Mark, Johnson , Scott K, Samet , Shelly, Pereira , Lenore, Kauvar , Lawrence Multiplexed screening of natural humoral immunity identifies antibodies at fine specificity for complex and dynamic viral targets. MAbs, 2014-01-08;6(2):460-73. 2014-01-08 [PMID: 24492306] (Bioassay, Human)	Bioassay	Human
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Imai F, Kishi H, Nakao K, Nishimura T, Minegishi T IL-6 up-regulates the expression of rat LH receptors during granulosa cell differentiation. Endocrinology, 2014-01-27;155(4):1436-44. 2014-01-27 [PMID: 24467743] (Bioassay, Rat)	Bioassay	Rat
Rodin S, Antonsson L, Niaudet C, Simonson O, Salmela E, Hansson E, Domogatskaya A, Xiao Z, Damdimopoulou P, Sheikhi M, Inzunza J, Nilsson A, Baker D, Kuiper R, Sun Y, Blennow E, Nordenskjold M, Grinnemo K, Kere J, Betsholtz C, Hovatta O, Tryggvason K Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment. Nat Commun, 2014-01-01;5(0):3195. 2014-01-01 [PMID: 24463987] (Bioassay, Human)	Bioassay	Human
Mok J, Mindrinos M, Davis R, Javanmard M Digital microfluidic assay for protein detection. Proc Natl Acad Sci U S A, 2014-01-21;111(6):2110-5. 2014-01-21 [PMID: 24449893] (Bioassay, ELISA Standard, N/A)	Bioassay, ELISA Standard	N/A
Kamat V, Paluru P, Myint M, French D, Gadue P, Diamond S MicroRNA screen of human embryonic stem cell differentiation reveals miR-105 as an enhancer of megakaryopoiesis from adult CD34+ cells. Stem Cells, 2014-05-01;32(5):1337-46. 2014-05-01 [PMID: 24446170] (Bioassay, Human)	Bioassay	Human
Gupta , Shashi, Hirota , Masao, Waugh , Sheela M, Murakami , Ikuo, Suzuki , Tomoki, Muraguchi , Masahiro, Shibamori , Masafumi, Ishikawa , Yuichi, Jarvis , Thale C, Carter , Jeffrey, Zhang , Chi, Gawande , Bharat, Vrkljan , Michael, Janjic , Nebojsa, Schneider , Daniel J Chemically modified DNA aptamers bind interleukin-6 with high affinity and inhibit signaling by blocking its interaction with interleukin-6 receptor. J Biol Chem, 2014-01-12;289(12):8706-19. 2014-01-12 [PMID: 24415766] (Bioassay, Human)	Bioassay	Human
Suzuki , Hitoshi, Raska , Milan, Yamada , Koshi, Moldoveanu , Zina, Julian , Bruce A, Wyatt , Robert J, Tomino , Yasuhiko, Gharavi , Ali G, Novak , Jan Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes. J Biol Chem, 2014-01-07;289(8):5330-9. 2014-01-07 [PMID: 24398680] (Bioassay, Human)	Bioassay	Human
Mleczko-Sanecka K, Roche F, Da Silva A, Call D, D'Alessio F, Ragab A, Lapinski P, Ummanni R, Korf U, Oakes C, Damm G, D'Alessandro L, Klingmuller U, King P, Boutros M, Hentze M, Muckenthaler M Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. Blood, 2014-01-02;123(10):1574-85. 2014-01-02 [PMID: 24385536] (Bioassay, Human)	Bioassay	Human
Meynard , Delphine, Sun , Chia Chi, Wu , Qifang, Chen , Wenjie, Chen , Shanzhuo, Nelson , Caroline, Waters , Michael, Babitt , Jodie L, Lin , Herbert Inflammation regulates TMPRSS6 expression via STAT5. PLoS ONE, 2013-12-23;8(12):e82127. 2013-12-23 [PMID: 24376517] (Bioassay, Human)	Bioassay	Human
Thanunchai , Maytawan, Kanrai , Pumaree, Wiboon-Ut , Suwimon, Puthavathana , Pilaipan, Hongeng , Suradej, Thitithanyanont , Arunee Tropism of avian influenza A (H5N1) virus to mesenchymal stem cells and CD34+ hematopoietic stem cells. PLoS ONE, 2013-12-10;8(12):e81805. 2013-12-10 [PMID: 24339969] (Bioassay, Human)	Bioassay	Human
Wong , Kwan Yeu, Wan , Thomas S, So , Chi Chiu, Chim , Chor San Establishment of a bortezomib-resistant Chinese human multiple myeloma cell line: MMLAL. Cancer Cell Int, 2013-12-12;13(1):122. 2013-12-12 [PMID: 24330858] (Cell Culture, Human)	Cell Culture	Human
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Sjeklocha L, Wong P, Belcher J, Vercellotti G, Steer C beta-Globin sleeping beauty transposon reduces red blood cell sickling in a patient-derived CD34(+)-based in vitro model. PLoS ONE, 2013-11-18;8(11):e80403. 2013-11-18 [PMID: 24260386] (Cell Culture, Human)	Cell Culture	Human
McFarland B, Hong S, Rajbhandari R, Twitty G, Gray G, Yu H, Benveniste E, Nozell S NF-kappaB-induced IL-6 ensures STAT3 activation and tumor aggressiveness in glioblastoma. PLoS ONE, 2013-11-11;8(11):e78728. 2013-11-11 [PMID: 24244348] (Cell Culture, Human)	Cell Culture	Human
Csaszar , Elizabet, Wang , Weijia, Usenko , Tatiana, Qiao , Wenlian, Delaney , Colleen, Bernstein , Irwin D, Zandstra , Peter W Blood stem cell fate regulation by Delta-1-mediated rewiring of IL-6 paracrine signaling. Blood, 2013-11-15;123(5):650-8. 2013-11-15 [PMID: 24243972] (Bioassay, Human)	Bioassay	Human
Dowty , Martin E, Jesson , Michael, Ghosh , Sarbani, Lee , Jamie, Meyer , Debra M, Krishnaswami , Sriram, Kishore , Nandini Preclinical to clinical translation of tofacitinib, a Janus kinase inhibitor, in rheumatoid arthritis. J Pharmacol Exp Ther, 2013-11-11;348(1):165-73. 2013-11-11 [PMID: 24218541] (Bioassay, Mouse)	Bioassay	Mouse
Mele V, Muraro M, Calabrese D, Pfaff D, Amatruda N, Amicarella F, Kvinlaug B, Bocelli-Tyndall C, Martin I, Resink T, Heberer M, Oertli D, Terracciano L, Spagnoli G, Iezzi G Mesenchymal stromal cells induce epithelial-to-mesenchymal transition in human colorectal cancer cells through the expression of surface-bound TGF-beta. Int J Cancer, 2014-01-30;134(11):2583-94. 2014-01-30 [PMID: 24214914] (Bioassay, Human)	Bioassay	Human
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Todd J, Simpson P, Estis J, Torres V, Wub A Reference range and short- and long-term biological variation of interleukin (IL)-6, IL-17A and tissue necrosis factor-alpha using high sensitivity assays. Cytokine, 2013-10-12;64(3):660-5. 2013-10-12 [PMID: 24128872] (ELISA (Standard), Human)	ELISA (Standard)	Human
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Fletcher E, Love-Homan L, Sobhakumari A, Feddersen C, Koch A, Goel A, Simons A EGFR inhibition induces proinflammatory cytokines via NOX4 in HNSCC. Mol Cancer Res, 2013-09-18;11(12):1574-84. 2013-09-18 [PMID: 24048704] (Bioassay, Human)	Bioassay	Human
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Yoo H, Seo J, Yoo J CTR9, a component of PAF complex, controls elongation block at the c-Fos locus via signal-dependent regulation of chromatin-bound NELF dissociation. PLoS ONE, 2013-04-11;8(4):e61055. 2013-04-11 [PMID: 23593388] (Bioassay, Human)	Bioassay	Human
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Melemedjian O, Tillu D, Asiedu M, Mandell E, Moy J, Blute V, Taylor C, Ghosh S, Price T BDNF regulates atypical PKC at spinal synapses to initiate and maintain a centralized chronic pain state. Mol Pain, 2013-03-20;9(0):12. 2013-03-20 [PMID: 23510079] (In Vivo, Mouse)	In Vivo	Mouse
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Yu , Jianhua, Peng , Yong, Wu , Lai-Chu, Xie , Zhiliang, Deng , Youcai, Hughes , Tiffany, He , Shun, Mo , XiaoKui, Chiu , Ming, Wang , Qi-En, He , Xiaoming, Liu , Shujun, Grever , Michael, Chan , Kenneth, Liu , Zhongfa Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia. PLoS ONE, 2013-02-13;8(2):e55934. 2013-02-13 [PMID: 23457487] (Bioassay, Human)	Bioassay	Human
Leone E, Morelli E, Di Martino M, Amodio N, Foresta U, Gulla A, Rossi M, Neri A, Giordano A, Munshi N, Anderson K, Tagliaferri P, Tassone P Targeting miR-21 inhibits in vitro and in vivo multiple myeloma cell growth. Clin Cancer Res, 2013-02-27;19(8):2096-106. 2013-02-27 [PMID: 23446999] (Bioassay, Human)	Bioassay	Human
Srivastava R, Lee S, Andrade Filho P, Lord C, Jie H, Davidson H, Lopez-Albaitero A, Gibson S, Gooding W, Ferrone S, Ferris R Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patients. Clin Cancer Res, 2013-02-26;19(7):1858-72. 2013-02-26 [PMID: 23444227] (Bioassay, Human)	Bioassay	Human
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Park J, Lim M, Cho M, Ryu J, Moon Y, Jhun J, Byun J, Kim E, Hwang S, Ju J, Kwok S, Kim H p53 controls autoimmune arthritis via STAT-mediated regulation of the Th17 cell/Treg cell balance in mice. Arthritis Rheum, 2013-04-01;65(4):949-59. 2013-04-01 [PMID: 23280308] (Bioassay, Human)	Bioassay	Human
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Nagineni CN, Kutty V, Detrick B, Hooks JJ Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta. J. Cell. Physiol., 2005-04-01;203(1):35-43. 2005-04-01 [PMID: 15368539] (Bioassay, Human)	Bioassay	Human
Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways. J. Immunol., 2004-09-01;173(5):3482-91. 2004-09-01 [PMID: 15322213] (Bioassay, Human)	Bioassay	Human
Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R IL-22 increases the innate immunity of tissues. Immunity, 2004-08-01;21(2):241-54. 2004-08-01 [PMID: 15308104] (Bioassay, Human)	Bioassay	Human
Phillips TM Rapid analysis of inflammatory cytokines in cerebrospinal fluid using chip-based immunoaffinity electrophoresis. Electrophoresis, 2004-06-01;25(10):1652-9. 2004-06-01 [PMID: 15188254]
Larsson M, Babcock E, Grakoui A, Shoukry N, Lauer G, Rice C, Walker C, Bhardwaj N Lack of phenotypic and functional impairment in dendritic cells from chimpanzees chronically infected with hepatitis C virus. J. Virol., 2004-06-01;78(12):6151-61. 2004-06-01 [PMID: 15163708] (Bioassay, Primate - Pan troglodytes (Chimpanzee))	Bioassay	Primate - Pan troglodytes (Chimpanzee)
Bas S, Gauthier BR, Spenato U, Stingelin S, Gabay C CD14 is an acute-phase protein. J. Immunol., 2004-04-01;172(7):4470-9. 2004-04-01 [PMID: 15034063] (Bioassay, Human)	Bioassay	Human
Copeland S, Siddiqui J, Remick D Direct comparison of traditional ELISAs and membrane protein arrays for detection and quantification of human cytokines. J. Immunol. Methods, 2004-01-01;284(1):99-106. 2004-01-01 [PMID: 14736420] (ELISA (Standard))	ELISA (Standard)
McLoughlin RM, Witowski J, Robson RL, Wilkinson TS, Hurst SM, Williams AS, Williams JD, Rose-John S, Jones SA, Topley N Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. J. Clin. Invest., 2003-08-01;112(4):598-607. 2003-08-01 [PMID: 12925700] (ELISA (Standard))	ELISA (Standard)
Hurst SM, McLoughlin RM, Monslow J, Owens S, Morgan L, Fuller GM, Topley N, Jones SA Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells. J. Immunol., 2002-11-01;169(9):5244-51. 2002-11-01 [PMID: 12391243] (ELISA (Standard))	ELISA (Standard)
Erices A, Conget P, Rojas C, Minguell JJ Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. Exp. Cell Res., 2002-10-15;280(1):24-32. 2002-10-15 [PMID: 12372336] (Bioassay, Human)	Bioassay	Human
Cork BA, 146, Tuckerman EM, Li TC, Laird SM Expression of interleukin (IL)-11 receptor by the human endometrium in vivo and effects of IL-11, IL-6 and LIF on the production of MMP and cytokines by human endometrial cells in vitro. 2002-09-01;8(9):841-8. 2002-09-01 [PMID: 12200462] (Bioassay, Human)	Bioassay	Human
Manz MG, 107325, Miyamoto T, Akashi K, Weissman IL Prospective isolation of human clonogenic common myeloid progenitors. Ultra-Sensitive and Semi-Quantitative Vertical Flow Assay for the Rapid Detection of Interleukin-6 in Inflammatory Diseases, 2002-08-22;99(18):11872-7. 2002-08-22 [PMID: 12193648] (Bioassay, Human)	Bioassay	Human
Shih CC, Hu MC, Hu J A secreted and LIF-mediated stromal cell-derived activity that promotes ex vivo expansion of human hematopoietic stem cells. Blood, 2000-03-15;95(6):1957-66. 2000-03-15 [PMID: 10706861] (Bioassay, Human)	Bioassay	Human
Gomez-Navarro J, ¯&h~²@á, Contreras JL, Arafat W, Jiang XL, Krisky D, Oligino T, Marconi P, Hubbard B, Glorioso JC, Curiel DT, Thomas JM Genetically modified CD34+ cells as cellular vehicles for gene delivery into areas of angiogenesis in a rhesus model. 2000-01-01;7(1):43-52. 2000-01-01 [PMID: 10680015] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque))	Bioassay	Primate - Macaca mulatta (Rhesus Macaque)
Akagi Y, Liu W, Zebrowski B, Xie K, Ellis LM Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I. Cancer Res., 1998-09-01;58(17):4008-14. 1998-09-01 [PMID: 9731515] (Bioassay, Human)	Bioassay	Human
Barcena A, Park SW, Banapour B, Muench MO, Mechetner E Expression of Fas/CD95 and Bcl-2 by primitive hematopoietic progenitors freshly isolated from human fetal liver. Blood, 1996-09-15;88(6):2013-25. 1996-09-15 [PMID: 8822920] (Bioassay, Human)	Bioassay	Human
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Array 206-IL

• IL-6 Antibodies
• IL-6 Antibody Pair
• IL-6 ELISA Kits
• IL-6 Lysate
• IL-6 Proteins
• IL-6 ELISAs
• IL-6 Proteins and Enzymes