Recombinant Cynomolgus/Rhesus Macaque IL-17F His Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The Interleukin 17 (IL-17) protein family, composed of six members (IL-17A through IL-17F), are secreted, structurally related proteins that share a conserved cystine-knot fold near the C-terminus, but have considerable sequence divergence at the N‑terminus. With the exception of IL-17B which exists as a non-covalently linked dimer, all IL-17 family members are disulfide-linked dimers. IL-17 proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions (1, 2). Cynomolgus IL-17F cDNA encodes a 163 amino acid (aa) protein with a putative 30 aa signal peptide. Mature cynomolgus IL-17F shares 96% and 100% aa sequence identity with human and rhesus macaque IL-17F, respectively. IL-17F is expressed in activated CD4⁺ T-cells and activated monocytes. Five receptors (IL-17 RA-RE) have been identified. Although the ligands for IL-17 RD and RE are not known yet, it is reported that IL-17 RA binds IL-17A, and IL-17 RB binds IL-17B and IL-17E. IL-17 RC binds IL‑17A and IL‑17F with similarly high affinity and functions as a receptor for both IL-17A and IL‑17F (3, 4). The biological activities mediated by IL-17F are similar to those of IL-17A. IL-17F stimulates production of IL-6, IL-8, G-CSF, and regulates cartilage matrix turnover by increasing matrix release and inhibiting new matrix synthesis (5). IL-17F also inhibits angiogenesis and induces production of IL-2, TGF-beta, and monocyte chemoattractant protein-1 in endothelial cells (6).

Array 10225-IL

• IL-17F Antibodies
• IL-17F ELISA Kit
• IL-17F Lysate
• IL-17F Protein
• IL-17F Proteins and Enzymes
• IL-17F ELISAs