Occludin Antibody (690213)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Occludin is an integral membrane protein with an apparent molecular mass of approximately 65 kDa.  It is localized exclusively at tight junctions (TJ) of select epithelial and endothelial cells.  The protein is 522 amino acids (aa) in length and contains a cytoplasmic N-terminus, four transmembrane domains, and a long COOH‑terminal cytoplasmic domain (domain E) that contains 255 aa.  Residues 1-66 make up the first cytoplasmic domain, and that is included in the MARVEL region consisting of aa 57-210.  The MARVEL region is a membrane-associating domain that spans aa 67-243.  Of note, residues 92-131 are glycine and tyrosine rich.  Residues 244-265 constitute the last transmembrane region, with aa 266-522 representing the long cytoplasmic domain termed domain E.  At the TJ, Occludin associates with membrane peripheral protein ZO-1 (220 kDa).  Human Occludin shares 90% aa sequence identity with mouse Occludin.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ICC.

Showing Publications 1 - 2 of 2.

Publications using MAB7074	Applications	Species
H Schmidt, P Braubach, C Schilpp, R Lochbaum, K Neuland, K Thompson, D Jonigk, M Frick, P Dietl, OH Wittekindt IL-13 Impairs Tight Junctions in Airway Epithelia Int J Mol Sci, 2019-06-30;20(13):. 2019-06-30 [PMID: 31262043] (ICC, Human)	ICC	Human
Dan Ting Kho, Rebecca Johnson, Laverne Robilliard, Elyce du Mez, Julie McIntosh, Simon J. O’Carroll et al. ECIS technology reveals that monocytes isolated by CD14+ve selection mediate greater loss of BBB integrity than untouched monocytes, which occurs to a greater extent with IL-1 beta activated endothelium in comparison to TNF alpha PLOS ONE 2017-07-21 [PMID: 28732059]

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	ICC	Pig	06/07/2017	View Summary Application Immunocytochemistry Sample Tested Hep2G cells Species Pig Lot N/A
Enlarge	5 reviewed by: Verified Customer	ICC	Pig	06/07/2017	View Summary Application Immunocytochemistry Sample Tested pig SC cells Species Pig Lot N/A

Array MAB7074

• Occludin Antibodies
• Occludin ELISA Kits
• Occludin Lysate
• Occludin Proteins