Rat Nrf2 ELISA Kit (Colorimetric)

Nrf2 is a transcription factor which belongs to the Cap N Collar (CNC-bZIP) subfamily with an implication in adaptive responses to oxidative stress. Nrf2 is a basic leucine zipper transcription factor that can bind to a NF-E2/AP-1 repeat sequence in the promoter of the beta-globin gene and has two types of binding partners, a cytoplasmic repressor (Keap I) and multiple nuclear binding partners. During oxidative stress on a cell, Nrf2 is released from Keap I, possibly via PKC phosphorylation at serine 40, and translocates to the nucleus. In the nucleus, Nrf2 binds to antioxidant responsive element (ARE) and leads to transcriptional activation of downstream genes for GSTs, glutamate-cysteine ligase, HO-1, and thioredoxin. Nrf2 and its downstream proteins have shown to have important functions in protection against oxidative stress or chemical-induced cellular damage in liver and lung, prevention in cancer formation in GI tract, and promotion of the wound-healing process.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.

We have publications tested in 1 application: ELISA.

Showing Publications 1 - 7 of 7.

Publications using NBP3-08161	Applications	Species
Rania H. Abu-Baih, Dalia H. Abu-Baih, Sara Mohamed Naguib Abdel-Hafez, Moustafa Fathy Activation of SIRT1/Nrf2/HO-1 and Beclin-1/AMPK/mTOR autophagy pathways by eprosartan ameliorates testicular dysfunction induced by testicular torsion in rats Scientific Reports 2024-05-31 [PMID: 38822026]
Dalia O. Saleh, Sara M. Baraka, Gehad A. Abdel Jaleel, Azza Hassan, Omar A. Ahmed-Farid Eugenol alleviates acrylamide-induced rat testicular toxicity by modulating AMPK/p-AKT/mTOR signaling pathway and blood–testis barrier remodeling Scientific Reports 2024-01-22 [PMID: 38253778]
Mohamed F. Balaha, Ahmed A. Alamer, Rana M. Aldossari, Alhussain H. Aodah, Azza I. Helal, Ahmed M. Kabel, Patrick Geraghty Amentoflavone Mitigates Cyclophosphamide-Induced Pulmonary Toxicity: Involvement of -SIRT-1/Nrf2/Keap1 Axis, JAK-2/STAT-3 Signaling, and Apoptosis Medicina 2023-12-04 [PMID: 38138222]
Jwharah M Al Jadani, Nawal A Albadr, Ghedeir M Alshammari, Soheir A Almasri, Farah Fayez Alfayez, Mohammed Abdo Yahya Esculeogenin A, a Glycan from Tomato, Alleviates Nonalcoholic Fatty Liver Disease in Rats through Hypolipidemic, Antioxidant, and Anti-Inflammatory Effects. Nutrients 2023-11-27 [PMID: 38004149]
ALTamimi JZ, AlFaris NA, Alshammari GM et al. Esculeoside A Decreases Diabetic Cardiomyopathy in Streptozotocin-Treated Rats by Attenuating Oxidative Stress, Inflammation, Fibrosis, and Apoptosis: Impressive Role of Nrf2 Medicina (Kaunas, Lithuania) 2023-10-14 [PMID: 37893548] (ELISA)	ELISA
El-Deeb AM, Mohamed AF, El-Yamany MF, El-Tanbouly DM Novel trajectories of the NK1R antagonist aprepitant in rotenone-induced Parkinsonism-like symptoms in rats: Involvement of ERK5/KLF4/p62/Nrf2 signaling axis Chemico-biological interactions 2023-08-01 [PMID: 37224993] (ELISA)	ELISA
Ahmed M Kabel, Samir A Salama, Hany M Borg, Dina A Ali, Maaly A Abd Elmaaboud Targeting p-AKT/mTOR/MAP kinase signaling, NLRP3 inflammasome and apoptosis by fluvastatin with or without taxifolin mitigates gonadal dysfunction induced by bisphenol-A in male rats. Human & experimental toxicology 2022-04-26 [PMID: 35465754]

Array NBP3-08161

• Nrf2 Antibodies
• Nrf2 ELISA Kits
• Nrf2 Proteins