Mouse Nrf2 ELISA Kit (Colorimetric)

Nrf2 is a transcription factor which belongs to the Cap N Collar (CNC-bZIP) subfamily with an implication in adaptive responses to oxidative stress. Nrf2 is a basic leucine zipper transcription factor that can bind to a NF-E2/AP-1 repeat sequence in the promoter of the beta-globin gene and has two types of binding partners, a cytoplasmic repressor (Keap I) and multiple nuclear binding partners. During oxidative stress on a cell, Nrf2 is released from Keap I, possibly via PKC phosphorylation at serine 40, and translocates to the nucleus. In the nucleus, Nrf2 binds to antioxidant responsive element (ARE) and leads to transcriptional activation of downstream genes for GSTs, glutamate-cysteine ligase, HO-1, and thioredoxin. Nrf2 and its downstream proteins have shown to have important functions in protection against oxidative stress or chemical-induced cellular damage in liver and lung, prevention in cancer formation in GI tract, and promotion of the wound-healing process.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: ELISA.

Showing Publications 1 - 4 of 4.

Publications using NBP2-76758	Applications	Species
Ushimoto C, Sugiki S, Kunii K et al. Dynamic change and preventive role of stress response via Keap1-Nrf2 during renal crystal formation Free radical biology & medicine 2023-07-13 [PMID: 37451369] (ELISA)	ELISA
Somayajulu M, McClellan SA, Wright R et al. Airborne Exposure of the Cornea to PM10 Induces Oxidative Stress and Disrupts Nrf2 Mediated Anti-Oxidant Defenses International journal of molecular sciences 2023-02-15 [PMID: 36835320] (ELISA, Mouse)	ELISA	Mouse
Ghanim By, Ahmad Mi, Abdallah Qm Et Al. Modulation of NRF2/ARE pathway- and cell death-related genes during drug-induced liver injury Human & experimental toxicology 2021-07-05 [PMID: 34219507]
Estatieh ON Evaluation of the Antioxidant and Metabolic Effects of Trolox on Acetaminophen-Induced Hepatotoxicity Thesis 2021-01-01 (ELISA)	ELISA

Array NBP2-76758

• Nrf2 Antibodies
• Nrf2 ELISA Kits
• Nrf2 Proteins