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n-Myc Antibody (NMYC-1) [PE]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ChIP, Flow, GS, ICC/IF, IP, ChIP, CyTOF-ready
Clone
NMYC-1
Clonality
Monoclonal
Host
Mouse
Conjugate
PE

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n-Myc Antibody (NMYC-1) [PE] Summary

Immunogen
A synthetic peptide (SPYVESEDAPPQKC) conjugated to KLH, corresponding to amino acids 327-339 of human n-Myc. [UniProt# P04198]
Localization
Nuclear, some cytoplasmic.
Specificity
This antibody does not react with c-Myc or L-Myc.
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Mouse
Gene
MYCN
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Chromatin Immunoprecipitation (ChIP)
  • Chromatin Immunoprecipitation
  • CyTOF-ready
  • Flow Cytometry
  • Gel Super Shift Assays
  • Immunocytochemistry/ Immunofluorescence
  • Immunoprecipitation
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Alternate Names for n-Myc Antibody (NMYC-1) [PE]

  • BHLHE37
  • bHLHe37N-myc proto-oncogene protein
  • Class E basic helix-loop-helix protein 37
  • MODED
  • neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene
  • N-myc
  • NMYCneuroblastoma MYC oncogene
  • ODED
  • oncogene NMYC
  • pp65/67
  • v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived
  • v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)

Background

n-Myc is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Video Protocols

WB Video Protocol
ChIP Video Protocol
ChIP Webinar
ICC/IF Video Protocol

FAQs for n-Myc Antibody (NB200-109PE) (0)

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Secondary Antibodies

 

Isotype Controls

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Research Areas for n-Myc Antibody (NB200-109PE)

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Blogs on n-Myc.

Dual applications of a c-Myc antibody in mitochondrial research
c-Myc, a proto-oncogene, has documented involvement in cellular differentiation, cell growth, cell death and tumor formation.  Target genes of the Myc family include those that participate in cell survival, translation, transcription, metabolism and...  Read full blog post.

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Bioinformatics

Gene Symbol MYCN