MMP-8 Antibody (100608) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Matrix metalloproteinases (MMPs) are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-8 (neutrophil collagenase) is expressed in neutrophils, where it is stored in specific granules. MMP-8 release from the neutrophils is stimulated by various factors such as interleukins 1 and 8, TNF-alpha and GM-CSF. MMP-8 is capable of cleaving types I, II and III triple-helical collagen, gelatin peptides, fibronectin, proteoglycans, aggrecan, serpins, beta -casein and peptides such as angiotensin and substance P. In addition to its function in phagocytosis,
MMP‑8 has a high capacity for infiltrating connective tissue, and is implicated in the breakdown of the extracellular matrix in diseases such as rheumatoid arthritis. Structurally, MMP-8 consists of several domains: a pro-domain that is cleaved upon activation, a catalytic domain containing the zinc-binding site, a short hinge region and a hemopexin-like domain. MMP-8 is heavily glycosylated.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IHC-P, Western Blot.

Showing Publications 1 - 3 of 3.

Publications using MAB9081	Applications	Species
van Dijk R A, Rijs K et al. Systematic Evaluation of the Cellular Innate Immune Response During the Process of Human Atherosclerosis. J Am Heart Assoc 6/16/2016 [PMID: 27312803]
Pim J Koelink, Saskia A Overbeek, Saskia Braber, Mary E Morgan, Paul A J Henricks, Mojtaba Abdul Abdul Roda et al. Collagen degradation and neutrophilic infiltration: a vicious circle in inflammatory bowel disease Gut 4/1/2014 [PMID: 23525573]
Arechavaleta-Velasco F, Marciano D, Diaz-Cueto L, Parry S Matrix metalloproteinase-8 is expressed in human chorion during labor. Am. J. Obstet. Gynecol., 2004-03-01;190(3):843-50. 2004-03-01 [PMID: 15042023] (IHC-P, Western Blot, Human)	IHC-P, Western Blot	Human

Array MAB9081

• MMP-8 Antibodies
• MMP-8 Antibody Pair
• MMP-8 ELISA Kits
• MMP-8 Lysate
• MMP-8 Proteins
• MMP-8 Proteins and Enzymes
• MMP-8 ELISAs