MITF Antibody (C5) - BSA Free

MITF (microphthalmia-associated transcription factor) is a melanocytic nuclear protein that contains basic helix-loop-helix (HLH) and leucine zipper (LZ) domains. These protein motifs are frequently observed in other transcription factors and are particularly common to members of the Myc family. MITF can directly associate with DNA as a homodimer. It is required for the development and differentiation of melanocytes. Its expression is upregulated by cAMP and cAMP dependent pathways. MITF activates several different gene promoters by binding to their E-boxes. Tyrosinase, TRP-1 and TRP-2 are pigment synthesis genes activated by MITF. When MITF is phosphorylated on Serine 73 (via the MAPK pathway), it associates with coactivators of the p300/CBP family and enhances transcription. MITF has several isoforms including MITF-M which is specifically expressed in melanocytes. In Mitfdeficient mice there is a complete absence of melanocytes.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: IF/IHC, WB.

Showing Publications 1 - 2 of 2.

Publications using NB110-10872	Applications	Species
Emmons MF, Bennett RL, Riva A et al. HDAC8-mediated inhibition of EP300 drives a transcriptional state that increases melanoma brain metastasis Nature communications 2023-11-29 [PMID: 38030596] (WB, Human)	WB	Human
Xu Z, Li Y, Wang D et al. Mutated SASH1 promotes Mitf expression in a heterozygous mutated SASH1 knock in mouse model Int. J. Mol. Med. 2020-06-19 [PMID: 32582980] (WB, IF/IHC, Mouse)	WB, IF/IHC	Mouse

Array NB110-10872

• MITF Antibodies
• MITF Lysate
• MITF Proteins