IL-17RA/IL-17R Antibody

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IL-17 R, also known as IL-17 RA, is a 120 kDa type I transmembrane glycoprotein protein that plays a central role in inflammatory responses (1-3). Mature mouse
IL‑17 R consists of a 291 amino acid (aa) extracellular domain, a 21 aa transmembrane segment, and a 521 aa cytoplasmic domain (4). The cytoplasmic domain contains a region homologous to the TIR domain of the TLR/IL-1 R family (5). Mouse IL-17 R shares 84% and 72% aa sequence identity with rat and human IL-17 R, respectively. Within the extracellular domain, it shares 18-25% sequence identity with mouse IL-17 RB, C, D, and E. While the expression of IL-17 is restricted to activated T cells, IL-17 R exhibits a broad tissue distribution (4). Even in the absence of ligand, IL-17 R exists on the cell surface as a multimer (6). IL-17 R can bind IL-17 but must associate with IL-17 RC to transduce signals (7, 8). Interestingly, human IL-17 R does not appear to form productive complexes with mouse IL-17 RC (8). The IL-17 R can also signal in response to IL-17F (9). IL-17 R ligation promotes T cell activation and the production of IL-6, G-CSF, SCF, and multiple pro‑inflammatory chemokines (4, 7, 9, 10). IL-17A and IL-17F synergize with TNF-alpha in the induction of CXCL1, G-CSF, and IL-6 (9, 11). This effect requires the presence of both TNF RI and TNF RII (9). IL-17 interactions with IL-17 R also inhibit the TNF-alpha induced upregulation of fibroblast CCL5 and VCAM-1 (11). CCL5 and VCAM-1 induced effects are differentially sensitive to blockade with IL-17 R specific antibodies, suggesting that IL-17 R triggers divergent intracellular signals (11). In vivo, IL‑17 R activity is important for increased generation of neutrophils and their recruitment to sites of inflammation (10, 12, 13). IL-17 R is required for host defense against microbial infection and for the progression of arthritis from inflammation to destructive joint erosion (10, 13).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 5 applications: Flow Cytometry, ICC, Immunoprecipitation, Neutralization, Western Blot.

Showing Publications 1 - 10 of 10.

Publications using AF448	Applications	Species
BK Tusi, SL Wolock, C Weinreb, Y Hwang, D Hidalgo, R Zilionis, A Waisman, JR Huh, AM Klein, M Socolovsky Population snapshots predict early haematopoietic and erythroid hierarchies Nature, 2018-02-21;0(0):. 2018-02-21 [PMID: 29466336] (Western Blot, Mouse)	Western Blot	Mouse
Keisa W. Mathis, Erin B. Taylor, Michael J. Ryan Anti-CD3 antibody therapy attenuates the progression of hypertension in female mice with systemic lupus erythematosus Pharmacological Research 2017-06-01 [PMID: 28400152]
IL-17 Augments B Cell Activation in Ocular Surface Autoimmunity J Immunol, 2016-09-21;0(0):. 2016-09-21 [PMID: 27655846] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Ding Y, Li J, Wu Q et al. IL-17RA Is Essential for Optimal Localization of Follicular Th Cells in the Germinal Center Light Zone To Promote Autoantibody-Producing B Cells. J Immunol 8/15/2013 [PMID: 23858031]
Sikora AG, Jaffarzad N, Hailemichael Y, Gelbard A, Stonier SW, Schluns KS, Frasca L, Lou Y, Liu C, Andersson HA, Hwu P, Overwijk WW IFN-alpha enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor activity. J. Immunol., 2009-06-15;182(12):7398-407. 2009-06-15 [PMID: 19494262] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Nichols JR, Aldrich AL, Mariani MM, Vidlak D, Esen N, Kielian T TLR2 deficiency leads to increased Th17 infiltrates in experimental brain abscesses. J. Immunol., 2009-06-01;182(11):7119-30. 2009-06-01 [PMID: 19454709] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Das Sarma J, Ciric B, Marek R, Sadhukhan S, Caruso M, Shafagh J, Fitzgerald D, Shindler K, Rostami A Functional interleukin-17 receptor A is expressed in central nervous system glia and upregulated in experimental autoimmune encephalomyelitis. J Neuroinflammation, 2009-04-28;6(0):14. 2009-04-28 [PMID: 19400960] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Rong Z, Wang A, Li Z, Ren Y, Cheng L, Li Y, Wang Y, Ren F, Zhang X, Hu J, Chang Z IL-17RD (Sef or IL-17RLM) interacts with IL-17 receptor and mediates IL-17 signaling. Cell Res., 2009-02-01;19(2):208-15. 2009-02-01 [PMID: 19079364] (Immunoprecipitation, Western Blot, Mouse)	Immunoprecipitation, Western Blot	Mouse
Molesworth-Kenyon SJ, Yin R, Oakes JE, Lausch RN IL-17 receptor signaling influences virus-induced corneal inflammation. J. Leukoc. Biol., 2007-11-12;83(2):401-8. 2007-11-12 [PMID: 17998300] (ICC, Mouse)	ICC	Mouse
Burchill MA, Nardelli DT, England DM, DeCoster DJ, Christopherson JA, Callister SM, Schell RF Inhibition of interleukin-17 prevents the development of arthritis in vaccinated mice challenged with Borrelia burgdorferi. Infect. Immun., 2003-06-01;71(6):3437-42. 2003-06-01 [PMID: 12761128] (Neutralization, Mouse)	Neutralization	Mouse

Array AF448

• IL-17RA/IL-17R Antibodies
• IL-17RA/IL-17R Antibody Pair
• IL-17RA/IL-17R Proteins and Enzymes
• IL-17RA/IL-17R ELISA