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IL-10R alpha Antibody (714212) [Biotin]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, CyTOF-ready
Clone
714212
Clonality
Monoclonal
Host
Mouse
Conjugate
Biotin

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB2742U-100UG
Alexa Fluor 405
FAB2742V-100UG
Alexa Fluor 488
FAB2742G-100UG
Alexa Fluor 532
FAB2742X
Alexa Fluor 594
FAB2742T-100UG
Alexa Fluor 647
FAB2742R-100UG
Alexa Fluor 700
FAB2742N-100UG
Alexa Fluor 750
FAB2742S-100UG
Allophycocyanin
FAB2742A
Allophycocyanin/Cy7
FAB2742APCCY7
DyLight 350
FAB2742D
DyLight 405
FAB2742E
DyLight 488
FAB2742K
DyLight 550
FAB2742L
DyLight 594
FAB2742M
DyLight 650
FAB2742W
DyLight 680
FAB2742Y
DyLight 755
FAB2742Z
FITC
FAB2742F
HRP
FAB2742H
Janelia Fluor 549
FAB2742I
Janelia Fluor 646
FAB2742J
PE
FAB2742P
PE/Atto594
FAB2742PEATT594
PE/Cy5.5
FAB2742PECY55
PE/Cy7
FAB2742PECY7
PerCP
FAB2742C
Unconjugated
MAB2742
mFluor Violet 450 SE
FAB2742MFV450
mFluor Violet 500 SE
FAB2742MFV500
mFluor Violet 610 SE
FAB2742MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB2742
Carrier Free
MAB2742
Carrier Free
MAB2742-SP
Carrier Free
FAB2742V-100UG
Carrier Free
FAB2742U-100UG
Carrier Free
FAB2742T-100UG
Carrier Free
FAB2742S-100UG
Carrier Free
FAB2742R-100UG
Carrier Free
FAB2742N-100UG
Carrier Free
FAB2742G-100UG
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IL-10R alpha Antibody (714212) [Biotin] Summary

Immunogen
Mouse myeloma cell line NS0-derived and S. frugiperda insect ovarian cell line Sf 21-derived recombinant human IL-10 R alpha
His22-Asn235
Accession # Q13651
Specificity
Detects human IL-10 R alpha in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant mouse IL-10 R alpha or recombinant human (rh) IL-10 R beta is observed. In Western blots, no cross-reactivity with rhIL-10 R beta is observed.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
IL10RA
Purity
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from hybridoma culture supernatant

Alternate Names for IL-10R alpha Antibody (714212) [Biotin]

  • CD210 antigen
  • CDw210a
  • HIL-10R
  • IBD28
  • IL-10 R alpha
  • IL-10 receptor subunit alpha
  • IL10R alpha
  • IL-10R subunit 1
  • IL-10R1
  • IL10RA
  • IL-10Ra
  • IL10RIL-10R subunit alpha
  • interleukin 10 receptor, alpha
  • interleukin-10 receptor alpha chain
  • Interleukin-10 receptor subunit 1
  • interleukin-10 receptor subunit alpha

Background

The IL-10 receptor, IL-10R, is a member of the class II subgroup of the cytokine receptor family and exhibits structural similarity to the interferon receptor. IL-10R is expressed in B cells and T helper cells, as well as in LPS-induced mouse fibroblasts. Overall, mouse IL-10R and human IL-10R share 60% sequence identity at the protein level. Stimulation with IL-10 leads to tyrosine phosphorylation of JAK1 and Tyk2, but not JAK2 or JAK3. In addition to its role as an antagonist of IFN-gamma-mediated macrophage activation, IL-10Ralpha transmits differentiation as well as proliferative signals. IL-10R is constitutively expressed on human natural killer (NK) cells and the direct binding of IL-10 potentiates cytokine production by human NK cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol IL10RA