Species: Hu
Applications: B/N
Host: Mouse Monoclonal
Species: Mu
Applications: WB, B/N
Host: Goat Polyclonal
Species: Hu
Applications: WB, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: Bioactivity
Species: Hu
Applications: Bioactivity, GelChrom
Species: Pm-Cm
Applications: Bioactivity
Description
The IL-10 receptor, IL-10R, is a member of the class II subgroup of the cytokine receptor family and exhibits structural similarity to the interferon receptor. IL-10R is expressed in B cells and T helper cells, as well as in LPS-induced mouse fibroblasts. Overall, mouse IL-10R and human IL-10R share 60% sequence identity at the protein level. Stimulation with IL-10 leads to tyrosine phosphorylation of JAK1 and Tyk2, but not JAK2 or JAK3. In addition to its role as an antagonist of IFN-gamma-mediated macrophage activation, IL-10Ralpha transmits differentiation as well as proliferative signals. IL-10R is constitutively expressed on human natural killer (NK) cells and the direct binding of IL-10 potentiates cytokine production by human NK cells.
Bioinformatics
| Entrez |
Mouse
Human
|
| Uniprot |
Human
Human
Human
|
| Product By Gene ID |
3587 |
| Alternate Names |
- CD210 antigen
- CDw210a
- CDW210A
- HIL-10R
- IBD28
- IL-10 receptor subunit alpha
- IL-10R subunit 1
- IL-10R1
- IL-10RA
- IL10RIL-10R subunit alpha
- interleukin 10 receptor, alpha
- interleukin-10 receptor alpha chain
- Interleukin-10 receptor subunit 1
- interleukin-10 receptor subunit alpha
|
![Neutralization IL-10R alpha Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/IL-10_R_alpha_AF-474-NA_Block_Neutralize_8724.jpg)
![Immunocytochemistry/ Immunofluorescence IL-10R alpha Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af-474-na_mouse-il-10-r-alpha-affinity-purified-polyclonal-ab-8220249505988.jpg)
![Western Blot IL-10R alpha Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af-474-na_mouse-il-10-r-alpha-affinity-purified-polyclonal-ab-8220249501921.jpg)
![Western Blot IL-10R alpha Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af-474-na_mouse-il-10-r-alpha-affinity-purified-polyclonal-ab-8220249501918.jpg)
![Immunocytochemistry/ Immunofluorescence IL-10R alpha Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af-474-na_mouse-il-10-r-alpha-affinity-purified-polyclonal-ab-8220249504613.jpg)
![N/A IL-10R alpha Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/af-474-na_mouse-il-10-r-alpha-affinity-purified-polyclonal-ab-822024102949..jpg)
![Binding Activity IL-10R alpha [Biotin]](http://images.novusbio.com/fullsize/protein/avi9044_recombinant-human-il-10-r-alpha-fc-avi-tag-protein-cf-binding-activity-19112020154359.jpg)
![SDS-PAGE IL-10R alpha [Biotin]](http://images.novusbio.com/fullsize/protein/avi9044_recombinant-human-il-10-r-alpha-fc-avi-tag-protein-cf-sds-page-311202013590.jpg)
![Inhibition Activity IL-10R alpha [Unconjugated]](http://images.novusbio.com/fullsize2/IL10_R_alpha_10186RI_2632.jpg)
![SDS-PAGE IL-10R alpha [Unconjugated]](http://images.novusbio.com/fullsize2/IL10_R_alpha_10186RI_2554.jpg)