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IL-10R alpha Antibody (1B1.3a) [DyLight 650]

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Product Details

Summary
Reactivity Mu, Hu(-)Species Glossary
Applications Flow
Clone
1B1.3a
Clonality
Monoclonal
Host
Rat
Conjugate
DyLight 650

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB100-63577AF350
Alexa Fluor 405
NB100-63577AF405
Alexa Fluor 488
NB100-63577AF488
Alexa Fluor 532
NB100-63577AF532
Alexa Fluor 594
NB100-63577AF594
Alexa Fluor 647
NB100-63577AF647
Alexa Fluor 700
NB100-63577AF700
Alexa Fluor 750
NB100-63577AF750
Allophycocyanin
NB100-63577APC
Biotin
NB100-63577B
DyLight 350
NB100-63577UV
DyLight 405
NB100-63577V
DyLight 488
NB100-63577G
DyLight 550
NB100-63577R
DyLight 594
NB100-63577DL594
DyLight 680
NB100-63577FR
DyLight 755
NB100-63577IR
FITC
NB100-63577F
HRP
NB100-63577H
Janelia Fluor 549
NB100-63577JF549
Janelia Fluor 646
NB100-63577JF646
PE
NB100-63577PE
PerCP
NB100-63577PCP
Unconjugated
NB100-63577
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IL-10R alpha Antibody (1B1.3a) [DyLight 650] Summary

Immunogen
Purified recombinant extracellular region of mouse CDw210a
Specificity
NB100-63577 recognizes mouse CDw210a, a cell surface glycoprotein of approximately 110KD, also known as Interleukin-10 receptor 1 (IL-10R1). The epitope recognised by this antibody has been localised to the ligand binding domain within the extracellular region of mouse CDw210a. Mouse CDw210a is expressed by a range of cells including thymocytes, T cells, B cells and monocytes. This clone is reported to neutralize the effects of IL-10 (1).
Isotype
IgG1
Clonality
Monoclonal
Host
Rat
Gene
IL10RA
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Reacts with Mouse. Does not react with Human.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for IL-10R alpha Antibody (1B1.3a) [DyLight 650]

  • CD210 antigen
  • CDw210a
  • HIL-10R
  • IBD28
  • IL-10 R alpha
  • IL-10 receptor subunit alpha
  • IL10R alpha
  • IL-10R subunit 1
  • IL-10R1
  • IL10RA
  • IL-10Ra
  • IL10RIL-10R subunit alpha
  • interleukin 10 receptor, alpha
  • interleukin-10 receptor alpha chain
  • Interleukin-10 receptor subunit 1
  • interleukin-10 receptor subunit alpha

Background

The IL-10 receptor, IL-10R, is a member of the class II subgroup of the cytokine receptor family and exhibits structural similarity to the interferon receptor. IL-10R is expressed in B cells and T helper cells, as well as in LPS-induced mouse fibroblasts. Overall, mouse IL-10R and human IL-10R share 60% sequence identity at the protein level. Stimulation with IL-10 leads to tyrosine phosphorylation of JAK1 and Tyk2, but not JAK2 or JAK3. In addition to its role as an antagonist of IFN-gamma-mediated macrophage activation, IL-10Ralpha transmits differentiation as well as proliferative signals. IL-10R is constitutively expressed on human natural killer (NK) cells and the direct binding of IL-10 potentiates cytokine production by human NK cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Species: Hu
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(372 Publications)
Species: Hu
Applications: BA

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Bioinformatics

Gene Symbol IL10RA