IFN-alpha Antibody (MMHA-2) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: Flow Cytometry, IHC-P, Neutralization.

Showing Publications 1 - 10 of 13. Show All 13 Publications. Collapse Publications.

Publications using 21100-1	Applications	Species
Adrian Gervais, Francesca Rovida, Maria Antonietta Avanzini, Stefania Croce, Astrid Marchal, Shih-Ching Lin et al. Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in ∼40% of patients Journal of Experimental Medicine 9/4/2023 [PMID: 37347462]
J Hong, JH Lee, Z Zhang, Y Wu, M Yang, Y Liao, R de la Rosa, J Scheirer, D Pechacek, N Zhang, Z Xu, T Curiel, X Tan, TH Huang, K Xu PRC2-mediated epigenetic suppression of type I IFN-STAT2 signaling impairs antitumor immunity in luminal breast cancer Cancer Research, 2022-12-16;0(0):. 12/16/2022 [PMID: 36222718]
Qian Zhang, Andrés Pizzorno, Lisa Miorin, Paul Bastard, Adrian Gervais, Tom Le Voyer et al. Autoantibodies against type I IFNs in patients with critical influenza pneumonia Journal of Experimental Medicine 11/7/2022 [PMID: 36112363]
Kyung-min Lee, Chang-Ching Lin, Alberto Servetto, Joonbeom Bae, Vishal Kandagatla, Dan Ye et al. Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer Cancer Immunology Research 7/1/2022 [PMID: 35561311]
Paul Bastard, Adrian Gervais, Tom Le Voyer, Jérémie Rosain, Quentin Philippot, Jérémy Manry et al. Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths Sci Immunol 8/19/2021 [PMID: 34413139]
Paul Bastard, Eleftherios Michailidis, Hans-Heinrich Hoffmann, Marwa Chbihi, Tom Le Voyer, Jérémie Rosain et al. Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine Journal of Experimental Medicine 4/5/2021 [PMID: 33544838]
Wen‑Bin Zheng, Lu‑Jiao Li, Di‑Chen Zhao, Ou Wang, Yan Jiang, Wei‑Bo Xia et al. A novel variant in AIRE causing a rare, non‑classical autoimmune polyendocrine syndrome type 1 Molecular Medicine Reports 6/12/2020 [PMID: 32627016]
J Uebele, C Stein, MT Nguyen, A Schneider, F Kleinert, O Tichá, G Bierbaum, F Götz, I Bekeredjia Antigen delivery to dendritic cells shapes human CD4+ and CD8+ T cell memory responses to Staphylococcus aureus PLoS Pathog., 2017-05-25;13(5):e1006387. 2017-05-25 [PMID: 28542586] (Neutralization, Human)	Neutralization	Human
Gupta S, Termini J, Issac B, Guirado E, Stone G Constitutively Active MAVS Inhibits HIV-1 Replication via Type I Interferon Secretion and Induction of HIV-1 Restriction Factors. PLoS ONE, 2016-02-05;11(2):e0148929. 2016-02-05 [PMID: 26849062] (Neutralization, Human)	Neutralization	Human
Borhis G, Burelout C, Chaoul N, Smith N, Goujard C, Meyer L, Paul S, Saoudin H, Hosmalin A, Gilbert C, Herbeuval J, Richard Y Plasmacytoid dendritic cells and myeloid cells differently contribute to BAFF over-expression during primary HIV infection. AIDS, 2016-01-28;30(0):365-376. 2016-01-28 [PMID: 26558721] (Neutralization, Human)	Neutralization	Human
Zahn S, Rehkamper C, Kummerer BM, Ferring-Schmidt S, Bieber T, Tuting T, Wenzel J Evidence for a pathophysiological role of keratinocyte-derived type III interferon (IFN-lambda) in cutaneous lupus erythematosus. J. Invest. Dermatol., 2010-08-19;131(1):133-40. 2010-08-19 [PMID: 20720564] (IHC-P, Human)	IHC-P	Human
Moll HP, Freudenthaler H, Zommer A Neutralizing type I IFN antibodies trigger an IFN-like response in endothelial cells. J. Immunol., 2008-04-15;180(8):5250-6. 2008-04-15 [PMID: 18390705] (Neutralization, Human)	Neutralization	Human
Megjugorac NJ, Young HA, Amrute SB, Olshalsky SL, Fitzgerald-Bocarsly P Virally stimulated plasmacytoid dendritic cells produce chemokines and induce migration of T and NK cells. J. Leukoc. Biol., 2004-01-23;75(3):504-14. 2004-01-23 [PMID: 14742635] (Flow Cytometry, Human)	Flow Cytometry	Human
Show All 13 Publications. Collapse Publications.

Array 21100-1

• IFN-alpha Antibodies
• IFN-alpha ELISA Kits
• IFN-alpha ELISAs
• IFN-alpha Proteins and Enzymes