Human Myeloperoxidase DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Myeloperoxidase (MPO) is a heme-containing enzyme belonging to the XPO subfamily of peroxidases. It is an abundant neutrophil and monocyte glycoprotein that catalyzes the hydrogen peroxide dependent formation of hypochlorus acid (HOCl) and other reactive species. Enzymatically active MPO is a disulfide-linked tetramer that contains two heme groups and two copies each of the heavy and light chains. MPO binds Albumin, MMR, Cytokeratin 1 on vascular endothelial cells, HMW Kininogen, and Integrin CD11b/CD18 on neutrophils. These interactions promote MPO clearance, a reduction of nitric oxide and bradykinin levels, reduced vasodilation, and continued neutrophil activation. Neutrophil MPO is stored in cytoplasmic azurophilic granules. Upon cellular activation and degranulation, MPO is delivered into phagosomes where it is required for the killing of phagocytosed bacteria. Activated neutrophils also release granule contents extracellularly. Elevated plasma MPO levels have been associated with a variety of clinical conditions including systemic inflammation, eclampsia, risk of cardiovascular events, vascular endothelial dysfunction, severity of multiple sclerosis, and prospective mortality and oxidative stress during hemodialysis.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 10 of 26. Show All 26 Publications. Collapse Publications.

Publications using DY3174	Applications	Species
Grannes, H;Ueland, T;Simeone, P;Liani, R;Guagnano, MT;Aukrust, P;Michelsen, AE;Birkeland, K;di Castelnuovo, A;Cipollone, F;Consoli, A;Halvorsen, B;Gregersen, I;Santilli, F; Liraglutide and not lifestyle intervention reduces soluble CD163 after comparable weight loss in obese participants with prediabetes or type 2 diabetes mellitus Cardiovascular diabetology 2024-04-29 [PMID: 38685051] (Human)		Human
Vozza, EG;Daly, CM;O'Rourke, SA;Fitzgerald, HK;Dunne, A;McLoughlin, RM; Staphylococcus aureus suppresses the pentose phosphate pathway in human neutrophils via the adenosine receptor A2aR to enhance intracellular survival mBio 2023-12-18 [PMID: 38108639] (Human)		Human
Mihalic, ZN;Kloimböck, T;Cosic-Mujkanovic, N;Valadez-Cosmes, P;Maitz, K;Kindler, O;Wadsack, C;Heinemann, A;Marsche, G;Gauster, M;Pollheimer, J;Kargl, J; Myeloperoxidase enhances the migration and invasion of human choriocarcinoma JEG-3 cells Redox biology 2023-09-19 [PMID: 37776707] (Human)		Human
Flockhart, M;Nilsson, LC;Tillqvist, EN;Vinge, F;Millbert, F;Lännerström, J;Nilsson, PH;Samyn, D;Apró, W;Sundqvist, ML;Larsen, FJ; Glucosinolate-rich broccoli sprouts protect against oxidative stress and improve adaptations to intense exercise training Redox biology 2023-09-03 [PMID: 37688976] (Human)		Human
Pastorek, M;Kone?ná, B;Janko, J;Janovi?ová, ?;Podracká, ?;Záhumenský, J;Šte?ová, E;Dúbrava, M;Hodosy, J;Vlková, B;Celec, P; Mitochondria-induced formation of neutrophil extracellular traps is enhanced in the elderly via Toll-like receptor 9 Journal of leukocyte biology 2023-08-30 [PMID: 37648664] (Human)		Human
A Gaál Koval, ? Janovi?ová, J Hodosy, J Bábí?ková, D Vavrincová, P Vavrinec, P Boor, ? Podracká, K Šebeková, P Celec, ? Tóthová Extracellular DNA concentrations in various aetiologies of acute kidney injury Scientific Reports, 2022-10-07;12(1):16812. 2022-10-07 [PMID: 36207374] (Human)		Human
AR Gründing, MA Schneider, S Richtmann, M Kriegsmann, H Winter, B Martinez-D, S Varona, B Liu, DS DeLuca, J Held, S Wrenger, T Muley, M Meister, T Welte, S Janciauski Lung Adenocarcinoma Cell Sensitivity to Chemotherapies: A Spotlight on Lipid Droplets and SREBF1 Gene Cancers, 2022-09-14;14(18):. 2022-09-14 [PMID: 36139614] (Human)		Human
K Nakamura, H Nakayama, S Sasaki, K Takahashi, K Iwabuchi Mycobacterium avium-intracellulare complex promote release of pro-inflammatory enzymes matrix metalloproteinases by inducing neutrophil extracellular trap formation Scientific Reports, 2022-04-11;12(1):5181. 2022-04-11 [PMID: 35410994] (Human)		Human
S Hakki, EJ Robinson, MG Robson Circulating Interleukin-6 and CD16 positive monocytes increase following angioplasty of an arteriovenous fistula Scientific Reports, 2022-01-26;12(1):1427. 2022-01-26 [PMID: 35082332] (Human)		Human
A Topf, M Mirna, N Bacher, V Paar, C Edlinger, LJ Motloch, S Gharibeh, M Bannehr, UC Hoppe, M Lichtenaue The Value of Fetuin-A as a Predictor to Identify Takotsubo Patients at Risk of Cardiovascular Events Journal of cardiovascular development and disease, 2021-10-05;8(10):. 2021-10-05 [PMID: 34677196] (Human)		Human
LE Cabrera, PT Pekkarinen, M Alander, KHA Nowlan, NA Nguyen, S Jokiranta, S Kuivanen, A Patjas, S Mero, SH Pakkanen, S Heinonen, A Kantele, O Vapalahti, E Kekäläinen, T Strandin Characterization of low-density granulocytes in COVID-19 PloS Pathogens, 2021-07-06;17(7):e1009721. 2021-07-06 [PMID: 34228753] (Human)		Human
GR Kathamuthu, K Moideen, R Sridhar, D Baskaran, S Babu Reduced neutrophil granular proteins and post-treatment modulation in tuberculous lymphadenitis PLoS ONE, 2021-06-21;16(6):e0253534. 2021-06-21 [PMID: 34153068] (Human)		Human
JH Jeong, SJ Choi, SM Ahn, JS Oh, YG Kim, CK Lee, B Yoo, S Hong Neutrophil extracellular trap clearance by synovial macrophages in gout Arthritis Research & Therapy, 2021-03-19;23(1):88. 2021-03-19 [PMID: 33741037] (Human)		Human
M Tong, SE Hanna, VM Abrahams Polymicrobial stimulation of human fetal membranes induce neutrophil activation and neutrophil extracellular trap release Journal of reproductive immunology, 2021-03-09;145(0):103306. 2021-03-09 [PMID: 33725528] (Human)		Human
A Minami-Tak, H Iwata, K Miyosawa, T Shiozawa, H Hayashi, T Funamizu, K Ishii, Y Nozaki, H Tabuchi, G Sekita, K Shimada, M Sumiyoshi, Y Nakazato, H Daida, T Minamino The association between impairment of HDL cholesterol efflux capacity and atrial remodeling in atrial fibrillation Scientific Reports, 2021-02-11;11(1):3547. 2021-02-11 [PMID: 33574408] (Human)		Human
E Nikolaou, SP Jochems, E Mitsi, S Pojar, A Blizard, J Reiné, C Solórzano, E Negera, B Carniel, A Soares-Sch, V Connor, H Adler, SR Zaidi, C Hales, H Hill, A Hyder-Wrig, SB Gordon, J Rylance, DM Ferreira Experimental Human Challenge Defines Distinct Pneumococcal Kinetic Profiles and Mucosal Responses between Colonized and Non-Colonized Adults MBio, 2021-01-12;12(1):. 2021-01-12 [PMID: 33436429] (Human)		Human
C Thomas, H Nothaft, R Yadav, C Fodor, A Alemka, O Oni, M Bell, B Rada, CM Szymanski Characterization of ecotin homologs from Campylobacter rectus and Campylobacter showae PLoS ONE, 2020-12-30;15(12):e0244031. 2020-12-30 [PMID: 33378351] (Human)		Human
J Theprungsi, JT Thaden, RM Wierzbicki, AS Burns, S Skopelja-G, VG Fowler, KL Winthrop, IW Martin, WFC Rigby Low-Avidity Autoantibodies Against Bactericidal/Permeability Increasing Protein Occur in Gram-Negative and Gram-Positive Bacteremia Infect. Immun., 2020-09-18;0(0):. 2020-09-18 [PMID: 32747603] (Human)		Human
RD Williamson, FP McCarthy, LC Kenny, CM McCarthy Activation of a TLR9 mediated innate immune response in preeclampsia Sci Rep, 2019-04-11;9(1):5920. 2019-04-11 [PMID: 30976066] (Human)		Human
HM Alyami, LS Finoti, HS Teixeira, A Aljefri, DF Kinane, MR Benakanake Role of NOD1/NOD2 receptors in Fusobacterium nucleatum mediated NETosis Microb. Pathog., 2019-03-30;0(0):. 2019-03-30 [PMID: 30940608] (Human)		Human
D Emal, E Rampanelli, N Claessen, FJ Bemelman, JC Leemans, S Florquin, MC Dessing Calcineurin inhibitor Tacrolimus impairs host immune response against urinary tract infection Sci Rep, 2019-01-14;9(1):106. 2019-01-14 [PMID: 30643171] (Human)		Human
T Barliya, R Dardik, Y Nisgav, M Dachbash, D Gaton, G Kenet, R Ehrlich, D Weinberger, T Livnat Possible involvement of NETosis in inflammatory processes in the eye: Evidence from a small cohort of patients Mol. Vis., 2017-12-13;23(0):922-932. 2017-12-13 [PMID: 29296072] (Human)		Human
L Rocha-Penh, M Caldeira-D, JE Tanus-Sant, R de Carvalh, VC Sandrim Myeloperoxidase in Hypertensive Disorders of Pregnancy and Its Relation With Nitric Oxide Hypertension, 2017-05-01;0(0):. 2017-05-01 [PMID: 28461600] (Human)		Human
Swimming Motility Mediates the Formation of Neutrophil Extracellular Traps Induced by Flagellated Pseudomonas aeruginosa PLoS Pathog., 2016-11-17;12(11):e1005987. 2016-11-17 [PMID: 27855208] (Human)		Human
Koepke J, Dresel M, Schmid S, Greulich T, Beutel B, Schmeck B, Vogelmeier C, Janciauskiene S, Koczulla A Therapy with plasma purified alpha1-antitrypsin (Prolastin(R)) induces time-dependent changes in plasma levels of MMP-9 and MPO. PLoS ONE, 2015-01-30;10(0):. 2015-01-30 [PMID: 25635861] (Human)		Human
Yoo D, Winn M, Pang L, Moskowitz S, Malech H, Leto T, Rada B Release of cystic fibrosis airway inflammatory markers from Pseudomonas aeruginosa-stimulated human neutrophils involves NADPH oxidase-dependent extracellular DNA trap formation. J Immunol, 2014-04-16;192(10):4728-38. 2014-04-16 [PMID: 24740504] (Human)		Human
Show All 26 Publications. Collapse Publications.

Array DY3174

• Myeloperoxidase/MPO Antibodies
• Myeloperoxidase/MPO Kits
• Myeloperoxidase/MPO Lysate
• Myeloperoxidase/MPO Proteins
• Myeloperoxidase/MPO ELISAs
• Myeloperoxidase/MPO Proteins and Enzymes