Human CXCL4/PF4 Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CXCL4/PF4 is a secreted chemokine that is expressed by megakaryocytes and restrains the coagulation cascade. It is released by activated platelets and regulates Thrombin/Thrombomodulin complexes, activated Protein C (APC), Coagulation Factor Xa, and Fibrin. The anticoagulant heparin neutralizes CXCL4 procoagulant effects. Complexes of heparin and CXCL4 trigger antibody formation that causes the pathological syndrome HITT. Immunogenic complexes of CXCL4 with Apolipoprotein H contribute to antiphospholipid syndrome (APS). CXCL4 interferes with the proliferative and angiogenic functions of FGF-2 and VEGF. However, it can also exert proinflammatory and pro-atherogenic effects on monocytes, macrophages, and endothelial cells. CXCL4 may signal through CXCR3B in humans.

We have publications tested in 2 confirmed species: Human, Mouse.

Showing Publications 1 - 10 of 17. Show All 17 Publications. Collapse Publications.

Publications using DPF40	Applications	Species
Mochizuki, T;Ushiki, T;Suzuki, K;Sato, M;Ishiguro, H;Suwabe, T;Watanabe, S;Edama, M;Omori, G;Yamamoto, N;Kawase, T; Elevated IL-1? and Comparable IL-1 Receptor Antagonist Levels Are Characteristic Features of L-PRP in Female College Athletes Compared to Male Professional Soccer Players International journal of molecular sciences 2023-12-14 [PMID: 38139317] (Human)		Human
Z?bczyk, M;Kruk, A;Natorska, J;Undas, A; Low-grade endotoxemia in acute pulmonary embolism: Links with prothrombotic plasma fibrin clot phenotype Thrombosis research 2023-12-01 [PMID: 37949000] (Human)		Human
Mochizuki, T;Ushiki, T;Suzuki, K;Sato, M;Ishiguro, H;Suwabe, T;Edama, M;Omori, G;Yamamoto, N;Kawase, T; Characterization of Leukocyte- and Platelet-Rich Plasma Derived from Female Collage Athletes: A Cross-Sectional Cohort Study Focusing on Growth Factor, Inflammatory Cytokines, and Anti-Inflammatory Cytokine Levels International journal of molecular sciences 2023-09-02 [PMID: 37686398] (Human)		Human
Stewart, JC;Patel, JS;Polanka, BM;Gao, S;Nurnberger, JI;MacDonald, KL;Gupta, SK;Considine, RV;Kovacs, RJ;Vrany, EA;Berntson, J;Hsueh, L;Shell, AL;Rollman, BL;Callahan, CM; Effect of Modernized Collaborative Care for Depression on Depressive Symptoms and Cardiovascular Disease Risk Biomarkers: eIMPACT Randomized Controlled Trial Brain, behavior, and immunity 2023-05-18 [PMID: 37209779] (Human)		Human
RO Ali, GM Quinn, R Umarova, JA Haddad, GY Zhang, EC Townsend, L Scheuing, KL Hill, M Gewirtz, S Rampertaap, SD Rosenzweig, AT Remaley, JM Han, V Periwal, H Cai, PJ Walter, C Koh, EB Levy, DE Kleiner, O Etzion, T Heller Longitudinal multi-omics analyses of the gut-liver axis reveals metabolic dysregulation in hepatitis C infection and cirrhosis Nature Microbiology, 2022-12-15;0(0):. 2022-12-15 [PMID: 36522461] (Human)		Human
C Tacquard, C Mouriaux, X Delabranch, C Bourdon, A Eckly, S Magnenat, L Sattler, C Gachet, PM Mertes, B Hechler, PH Mangin Platelet dysfunction and thrombus instability in flow conditions in patients with severe COVID-19 Thrombosis Research, 2022-11-08;0(0):. 2022-11-08 [PMID: 36376109] (Human)		Human
H Kared, AS Wolf, A Alirezayla, A Ravussin, G Solum, TT Tran, F Lund-Johan, JT Vaage, LS Nissen-Mey, UC Nygaard, O Hungnes, AH Robertson, LM Næss, L Trogstad, P Magnus, LA Munthe, S Mjaaland Immune responses in Omicron SARS-CoV-2 breakthrough infection in vaccinated adults Nature Communications, 2022-07-18;13(1):4165. 2022-07-18 [PMID: 35851055] (Human)		Human
M Ebeyer-Mas, T Eichhorn, R Weiss, V Semak, L Lauková, MB Fischer, V Weber Heparin-Functionalized Adsorbents Eliminate Central Effectors of Immunothrombosis, including Platelet Factor 4, High-Mobility Group Box 1 Protein and Histones International Journal of Molecular Sciences, 2022-02-05;23(3):. 2022-02-05 [PMID: 35163743] (Human)		Human
S Nawrocka-M, J Biegus, M Hurkacz, M Guzik, M Rosiek-Bie, EA Jankowska, P Ponikowski, R Zymli?ski Differences in the Biomarker Profile of De Novo Acute Heart Failure versus Decompensation of Chronic Heart Failure Biomolecules, 2021-11-16;11(11):. 2021-11-16 [PMID: 34827701] (Human)		Human
M Mussbacher, TL Krammer, S Heber, WC Schrottmai, S Zeibig, HP Holthoff, D Pereyra, P Starlinger, M Hackl, A Assinger Impact of Anticoagulation and Sample Processing on the Quantification of Human Blood-Derived microRNA Signatures Cells, 2020-08-18;9(8):. 2020-08-18 [PMID: 32824700] (Human)		Human
M Z?bczyk, J Natorska, A Janion-Sad, KP Malinowski, M Janion, A Undas Elevated Lactate Levels in Acute Pulmonary Embolism Are Associated with Prothrombotic Fibrin Clot Properties: Contribution of NETs Formation J Clin Med, 2020-03-30;9(4):. 2020-03-30 [PMID: 32235490] (Human)		Human
CC Huang, CH Chou, SU Chen, HN Ho, YS Yang, MJ Chen Increased platelet factor 4 and aberrant permeability of follicular fluid in PCOS J. Formos. Med. Assoc., 2018-05-18;0(0):. 2018-05-18 [PMID: 29779926] (Human)		Human
M Mussbacher, WC Schrottmai, M Salzmann, C Brostjan, JA Schmid, P Starlinger, A Assinger Optimized plasma preparation is essential to monitor platelet-stored molecules in humans PLoS ONE, 2017-12-08;12(12):e0188921. 2017-12-08 [PMID: 29220362] (Human)		Human
Elizabeth R Volkmann Changes in plasma CXCL4 levels are associated with improvements in lung function in patients receiving immunosuppressive therapy for systemic sclerosis-related interstitial lung disease Arthritis Res. Ther, 2016-12-30;18(1):305. 2016-12-30 [PMID: 28038680] (Human)		Human
Unaltered Angiogenesis-Regulating Activities of Platelets in Mild Type 2 Diabetes Mellitus despite a Marked Platelet Hyperreactivity PLoS ONE, 2016-09-09;11(9):e0162405. 2016-09-09 [PMID: 27612088] (Human)		Human
Vir B Singh Smoothened Agonist Reduces Human Immunodeficiency Virus Type-1-Induced Blood-Brain Barrier Breakdown in Humanized Mice Sci Rep, 2016-05-31;6(0):26876. 2016-05-31 [PMID: 27241024] (Mouse)		Mouse
Proenca-Ferreira R, Brugnerotto A, Garrido V, Dominical V, Vital D, Ribeiro M, dos Santos M, Traina F, Olalla-Saad S, Costa F, Conran N Endothelial activation by platelets from sickle cell anemia patients. PLoS ONE, 2014-02-13;9(2):e89012. 2014-02-13 [PMID: 24551209] (Human)		Human
Show All 17 Publications. Collapse Publications.

Array DPF40

• CXCL4/PF4 Antibodies
• CXCL4/PF4 ELISA Kit
• CXCL4/PF4 Lysate
• CXCL4/PF4 Proteins
• CXCL4/PF4 Proteins and Enzymes
• CXCL4/PF4 ELISAs