HSPA8/HSC71/Hsc70 Antibody (521503) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The 70 kDa heat shock proteins (HSP70s) are a highly conserved family of stress response proteins. The HSP70 family of proteins contains both heat/stress inducible and constitutively expressed members known as heat shock cognate proteins. Heat Shock 70 kDa Protein 8 (HSPA8), also known as Heat Shock Cognate Protein 71 (HSC71), HSC70, HSP73, HSPA10 and LPS-associated protein 1 (LAP1), is a 646 amino acid (aa) heat shock cognate protein. Many HSPs function as molecular chaperones, facilitating the folding of other cellular proteins. HSPA8 plays an important role in cells by transiently associating with nascent polypeptides to facilitate correct folding. HSPA8 is a ubiquitously expressed protein and rapidly translocates from the cytoplasm to the nucleus in response to heat shock. Two alternatively spliced variants have been identified. This antibody detects isoform 1 but not isoform 2 (HSC54). Human HSPA8 shares greater than 99% identity with mouse and rat HSPA8.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: Western Blot.

Showing Publications 1 - 2 of 2.

Publications using MAB4148	Applications	Species
Vincent Deruelle, Stéphanie Bouillot, Viviana Job, Emmanuel Taillebourg, Marie-Odile Fauvarque, Ina Attrée et al. The bacterial toxin ExoU requires a host trafficking chaperone for transportation and to induce necrosis Nature Communications 2021-06-29 [PMID: 34188051]
Aoi , Jun, Endo , Motoyosh, Kadomatsu , Tsuyoshi, Miyata , Keishi, Ogata , Aki, Horiguchi , Haruki, Odagiri , Haruki, Masuda , Tetsuro, Fukushima , Satoshi, Jinnin , Masatosh, Hirakawa , Satoshi, Sawa , Tomohiro, Akaike , Takaaki, Ihn , Hironobu, Oike , Yuichi Angiopoietin-like protein 2 accelerates carcinogenesis by activating chronic inflammation and oxidative stress. Mol Cancer Res, 2013-11-20;12(2):239-49. 2013-11-20 [PMID: 24258150] (Western Blot, Mouse)	Western Blot	Mouse

Images	Ratings	Applications	Species	Date	Details
Enlarge	3 reviewed by: Verified Customer	Simple Western	Rat	01/04/2017	View Summary Application Simple Western Sample Tested B103 cells Species Rat Comments Comments Simple Western run of MAB4148 on rat B103 cells (~250, 750, and 1500 cell equivalents per lane [left to right]) using 5 µg/mL of antibody final. Overall, the signal is clean, although the band at 56 kDa was not expected and some cross-reactivity is seen with the 230-kDa fluorescent migration control.

Array MAB4148

• HSPA8/HSC71/Hsc70 Antibodies
• HSPA8/HSC71/Hsc70 ELISA Kits
• HSPA8/HSC71/Hsc70 Lysate
• HSPA8/HSC71/Hsc70 Protein