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HLA DPA Antibody (TAL3C3) [PE]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Func, IHC
Clone
TAL3C3
Clonality
Monoclonal
Host
Mouse
Conjugate
PE

Order Details

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HLA DPA Antibody (TAL3C3) [PE] Summary

Immunogen
Bristol 8 separated alpha chain preparation
Specificity
TAL 3C3 is reactive on fixed tissue, reacts to class II antigens and cross-reacts with smooth muscle. Not cytotoxic with rabbit complement. TAL 3C3 detects alpha chain only by western blot and not the dimer.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
HLA-DPA1
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Radioimmunoassay
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Alternate Names for HLA DPA Antibody (TAL3C3) [PE]

  • DP alpha 1 chain
  • HLA class II histocompatibility antigen, DP alpha chain
  • HLADP
  • HLA-SB alpha chain
  • major histocompatibility complex, class II, DP alpha 1
  • MHC class II antigen
  • MHC class II DP3-alpha
  • MHC class II DPA1
  • MHC class II HLA-DPA1 antigen
  • Primed lymphocyte test-1

Background

HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Bioinformatics

Gene Symbol HLA-DPA1