| Reactivity | Hu, Mu, RtSpecies Glossary |
| Applications | WB, Simple Western, KO |
| Clone | 2089B |
| Clonality | Monoclonal |
| Host | Rabbit |
| Conjugate | Unconjugated |
| Additional Information | Recombinant Monoclonal Antibody. |
| Immunogen | E. coli-derived recombinant human GRK2 Pro468-Leu689 Accession # P25098 |
| Specificity | Detects human GRK2 in direct ELISAs and Western blots. |
| Source | N/A |
| Isotype | IgG |
| Clonality | Monoclonal |
| Host | Rabbit |
| Purity Statement | Protein A or G purified from cell culture supernatant |
| Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
| Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
| Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. |
| Preservative | Sodium Azide |
| Reconstitution Instructions | Reconstitute at 0.5 mg/mL in sterile PBS. |
G protein-coupled receptor kinases (GRKs) are important modulators of G protein-coupled receptor (GPCR) signaling. Receptor phosphorylation by specific GRKs plays a key role in triggering rapid desensitization. The GRK family consists of 7 isoforms that share a central catalytic domain with homology to other serine/threonine kinases. The catalytic domain is flanked by an amino-terminal RGS domain of 183‑188 amino acids and a carboxyl-terminus of variable length. GRK2 is a member of the beta ARK subfamily, and was originally termed beta ‑adrenergic receptor kinase 1 ( beta ARK1).
![GRK2 Antibody (2089B) [Unconjugated]](/sites/all/modules/enterprise-tech/et_datasheets/images/novus_guarantee.png "GRK2 Antibody (2089B) [Unconjugated]")
Secondary Antibodies |
Isotype Controls |
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"Freeze!" - Arrestin Antibodies Used in New Serotonin Syndrome Study The beta-arrestin family regulate receptor binding of G-proteins, a group of seven transmembrane receptor proteins which includes the adrenergic, dopamine and serotonin receptors. Recently, arrestin antibodies were used in a study into Serotonin Syndr... Read full blog post. |
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