FUS Antibody

FUS, fused in sarcoma, encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. Involved in placental, cardiac, hepatic and embryonic development. NCOA6 is over-expressed in several breast cancer cell lines.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 3 applications: ICC/IF, IF/IHC, WB.

Showing Publications 1 - 10 of 19. Show All 19 Publications. Collapse Publications.

Publications using NBP1-89113	Applications	Species
Ziskin JL, Greicius MD, Zhu W et al. Neuropathologic analysis of Tyr69His TTR variant meningovascular amyloidosis with dementia. Acta Neuropathol Commun 2015-07-10 [PMID: 26156087] (IF/IHC, Human)	IF/IHC	Human
Barmada SJ, Ju S, Arjun A et al. Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1. Proc Natl Acad Sci U S A 2015-06-23 [PMID: 26056265] (IF/IHC, Rat)	IF/IHC	Rat
Ayaki T, Ito H, Fukushima H et al. Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant. Acta Neuropathol Commun 2014-12-10 [PMID: 25492614] (IF/IHC, Human)	IF/IHC	Human
Sephton CF, Tang AA, Kulkarni A et al. Activity-dependent FUS dysregulation disrupts synaptic homeostasis. Proc Natl Acad Sci U S A 2014-11-04 [PMID: 25324524] (WB, IF/IHC, Mouse)	WB, IF/IHC	Mouse
Nakamura M, Murray ME, Lin WL et al. Optineurin immunoreactivity in neuronal and glial intranuclear inclusions in adult-onset neuronal intranuclear inclusion disease. Am J Neurodegener Dis 2014-01-01 [PMID: 25232514] (IF/IHC, ICC/IF, Human)	IF/IHC, ICC/IF	Human
Qiu H, Lee S, Shang Y et al. ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects. J Clin Invest 2014-03-01 [PMID: 24509083]
Dobson-Stone C, Luty AA, Thompson EM et al. Frontotemporal dementia-amyotrophic lateral sclerosis syndrome locus on chromosome 16p12.1-q12.2: genetic, clinical and neuropathological analysis. Acta Neuropathol 2013-04-01 [PMID: 23338750]
Dormann D, Madl T, Valori CF et al. Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS. EMBO J 2012-11-14 [PMID: 22968170] (ICC/IF, IF/IHC)	ICC/IF, IF/IHC
Snowden JS, Rollinson S, Thompson JC et al. Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations. Brain 2012-03-01 [PMID: 22300873]
Neumann M, Bentmann E, Dormann D et al. FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations. Brain 2011-09-01 [PMID: 21856723]
Lashley T, Rohrer JD, Bandopadhyay R et al. A comparative clinical, pathological, biochemical and genetic study of fused in sarcoma proteinopathies. Brain 2011-09-01 [PMID: 21752791]
Pikkarainen M, Hartikainen P, Soininen H, Alafuzoff I. Distribution and Pattern of Pathology in Subjects with Familial or Sporadic Late-Onset Cerebellar Ataxia as Assessed by p62/Sequestosome Immunohistochemistry. Cerebellum. 2011-05-05 [PMID: 21544590]
Kino Y, Washizu C, Aquilanti E et al. Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations. Nucleic Acids Res 2011-04-01 [PMID: 21109527]
Deng HX, Zhai H, Bigio EH et al. FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis. Ann Neurol 2010-06-01 [PMID: 20517935] (IF/IHC, WB, ICC/IF, Human)	IF/IHC, WB, ICC/IF	Human
Urwin H, Josephs KA, Rohrer JD et al. FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration. Acta Neuropathol 2010-07-01 [PMID: 20490813]
Seelaar H, Klijnsma KY, de Koning I et al. Frequency of ubiquitin and FUS-positive, TDP-43-negative frontotemporal lobar degeneration. J Neurol 2010-05-01 [PMID: 19946779]
Munoz DG, Neumann M, Kusaka H et al. FUS pathology in basophilic inclusion body disease. Acta Neuropathol 2009-11-01 [PMID: 19830439]
Neumann M, Rademakers R, Roeber S et al. A new subtype of frontotemporal lobar degeneration with FUS pathology. Brain 2009-11-01 [PMID: 19674978]
Neumann M, Roeber S, Kretzschmar HA et al. Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease. Acta Neuropathol 2009-11-01 [PMID: 19669651]
Show All 19 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Kristi Bailey	IHC-P	Human	01/26/2018	View Summary Application Immunohistochemistry-Paraffin Sample Tested Human brain Species Human Lot J114737 Comments Comments FFPE 5micron sections, Citrate pretreatment, 1:500 20m, Ultravision DAB detection

Array NBP1-89113

• FUS Antibodies
• FUS ELISA Kits
• FUS Lysate
• FUS Proteins