Species: Hu, Mu, Rt, Bv
Applications: WB, ICC/IF, IHC, IP, KO
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Bv
Applications: WB, IHC, IP
Host: Rabbit Polyclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: WB, PAGE
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
FUS, fused in sarcoma, encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. Involved in placental, cardiac, hepatic and embryonic development. NCOA6 is over-expressed in several breast cancer cell lines.
Bioinformatics
Entrez |
Mouse Human |
Uniprot |
Human Human Mouse |
Product By Gene ID |
2521 |
Alternate Names |
- 75 kDa DNA-pairing protein
- ALS6
- amyotrophic lateral sclerosis 6
- FUS1
- fused in sarcoma
- fusion (involved in t(12;16) in malignant liposarcoma)
- fusion gene in myxoid liposarcoma
- fusion, derived from t(12;16) malignant liposarcoma
- fus-like protein
- heterogeneous nuclear ribonucleoprotein P2
- HNRNPP2
- Oncogene FUS
- Oncogene TLS
- POMP75
- POMp75
- RNA-binding protein FUS
- TLShnRNP-P2
- Translocated in liposarcoma protein
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Research Areas for FUS
Find related products by research area and learn more about each of the different research areas below.
CancerNeuroscience