FUS Antibody

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. Involved in placental, cardiac, hepatic and embryonic development. NCOA6 is over-expressed in several breast cancer cell lines.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: ICC/IF, IF/IHC, IHC-P, WB.

Showing Publications 1 - 6 of 6.

Publications using NB100-2599	Applications	Species
Cooper-Knock J, Walsh MJ, Higginbottom A et al. Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions. Brain. 2014-05-27 [PMID: 24866055] (IHC-P, Human)	IHC-P	Human
Vance C, Scotter EL, Nishimura AL et al. ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules Hum Mol Genet 2013-03-29 [PMID: 23474818] (WB, IHC-P, Human)	WB, IHC-P	Human
Seilhean D, Le Ber I, Sarazin M, Lacomblez L, Millecamps S, Salachas F, Pradat PF, Le Forestier N, LeGuern E, Dubois B, Meininger V, Brice A, Hauw JJ, Duyckaerts C. Fronto-temporal lobar degeneration: neuropathology in 60 cases. J Neural Transm;118(5):753-64. 2011-05-01 [PMID: 21541771] (IF/IHC, Human)	IF/IHC	Human
Spijkers XM, Pasteuning-Vuhman S, Dorleijn JC, et al. A directional 3D neurite outgrowth model for studying motor axon biology and disease Scientific reports 2021-01-22 [PMID: 33483540] (ICC/IF, Human)	ICC/IF	Human
Wharton, S B, Verber, N S Et al. Combined fused in sarcoma-positive (FUS+) basophilic inclusion body disease and atypical tauopathy presenting with an amyotrophic lateral sclerosis/motor neurone disease (ALS/MND)-plus phenotype. Neuropathol Appl Neurobiol 2019-10-01 [PMID: 30659642] (WB, Mouse)	WB	Mouse

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	ICC	Mouse	04/01/2017	View Summary Application Immunocytochemistry Sample Tested brain and spinal cord Species Mouse Lot N/A

Array NB100-2599

• FUS Antibodies
• FUS ELISA Kits
• FUS Lysate
• FUS Proteins