FEN-1 Antibody

FEN-1 (Flap Endonuclease and Five prime Exonuclease) is a 42 kDa protein that functions as an endonuclease that cleaves branched DNA structures containing single-stranded 5' flaps or as an exonuclease on DNA nicks and gaps. FEN-1 endonuclease and exonuclease activities are stimulated by an association with proliferating cell nuclear antigen (PCNA) in the nucleus. FEN-1 is believed to have important roles in DNA replication and repair and is required in cell-free DNA replication systems.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 9 of 9.

Publications using NB100-320	Applications	Species
Caston RA, Fortini P, Chen K et al. Maintenance of Flap Endonucleases for Long-Patch Base Excision DNA Repair in Mouse Muscle and Neuronal Cells Differentiated In Vitro International Journal of Molecular Sciences 2023-08-12 [PMID: 37628896] (WB)	WB
YY1 suppresses FEN1 over-expression and drug resistance in breast cancer Wang J, Zhou L, Li Z et al. Cancer 2005-07-07 [PMID: 25885449] (WB, Human)	WB	Human
Duxin JP, Moore HR, Sidorova J et al. Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication. J Biol Chem 2012-06-01 [PMID: 22570476]
Saharia A, Teasley DC, Duxin JP et al. FEN1 ensures telomere stability by facilitating replication fork re-initiation. J Biol Chem 2010-08-01 [PMID: 20551483]
Sampathi S, Bhusari A, Shen B et al. Human flap endonuclease I is in complex with telomerase and is required for telomerase-mediated telomere maintenance. J Biol Chem 2009-02-01 [PMID: 19068479]
Hegde ML, Theriot CA, Das A et al. Physical and functional interaction between human oxidized base-specific DNA glycosylase NEIL1 and flap endonuclease 1. J Biol Chem 2008-10-01 [PMID: 18662981]
Szczesny B, Tann AW, Longley MJ et al. Long patch base excision repair in mammalian mitochondrial genomes. J Biol Chem 2008-09-01 [PMID: 18635552]
Wang SC, Nakajima Y, Yu YL et al. Tyrosine phosphorylation controls PCNA function through protein stability. Nat Cell Biol 2006-12-01 [PMID: 17115032]
Muftuoglu M, Wong HK, Imam SZ et al. Telomere repeat binding factor 2 interacts with base excision repair proteins and stimulates DNA synthesis by DNA polymerase beta. Cancer Res 2006-01-01 [PMID: 16397223]

Array NB100-320

• FEN-1 Antibodies
• FEN-1 Lysate
• FEN-1 Proteins