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DYM Antibody

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Immunohistochemistry-Paraffin: DYM Antibody [NBP2-13942] - Staining of human liver shows strong cytoplasmic granular positivity in hepatocytes.
Immunohistochemistry-Paraffin: DYM Antibody [NBP2-13942] - Staining of human liver shows strong cytoplasmic granular positivity in hepatocytes.
Immunohistochemistry-Paraffin: DYM Antibody [NBP2-13942] - Staining of human fallopian tube shows strong cytoplasmic granular positivity in glandular cells.
Immunohistochemistry-Paraffin: DYM Antibody [NBP2-13942] - Staining of human kidney shows strong cytoplasmic granular positivity in cells in tubules.
Immunohistochemistry-Paraffin: DYM Antibody [NBP2-13942] - Staining of human pancreas shows strong cytoplasmic granular positivity in exocrine glandular cells.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

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DYM Antibody Summary

Immunogen
This antibody was developed against a recombinant protein corresponding to the amino acids: MTRTRDKYLHTNCLAALANMSAQFRSLHQYAAQRIISLFSLLSKKHNKVLEQATQSLRGSLSSNDVPLPDYAQDLNVIEEVIR
Predicted Species
Mouse (96%), Rat (98%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
DYM
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:20 - 1:50
  • Immunohistochemistry-Paraffin 1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
DYM Protein (NBP2-13942PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for DYM Antibody

  • DMCSMCFLJ20071
  • Dyggve-Melchior-Clausen syndrome protein
  • dymeclin
  • FLJ90130

Background

The DYM gene encodes for a protein that is critical for correct organization of Golgi apparatus and is involved in skeletal development and brain functioning. Isoform 1 of this protein is 669 amino acids long at nearly 76 kDA while isoform 2 is 479 amino acids long at approximately 54 kDA. DYM is known to interact with ACO2, C12orf4, SPAG9, GMPS, and TBC1D22B genes. Defects in the DYM gene are known to cause Dyggve-Melchior-Clausen syndrome as well as Smith-McCort Dysplasia. DYM has also been investigated for its role in various diseases such as thyroiditis, acromegaly, dwarfism, gangliosidosis, turner syndrome, atherosclerosis, microencephaly, intellectual disabilities, and sponastrime dysplasia.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol DYM