Cadherin-13 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Cadherin-13, also known as T-Cadherin and H-Cadherin, is a 105 kDa member of the cadherin family of transmembrane glycoproteins that mediate calcium-dependent intercellular adhesion (1). However, Cadherin-13 is an atypical member, lacking transmembrane and cytosolic domains and containing a GPI moiety that anchors Cadherin-13 to the plasma membrane (1‑2). Human Cadherin-13 is synthesized as a 713 amino acid (aa) precursor that contains a 22 aa signal sequence, a 116 aa propeptide, a 555 aa mature chain, and a second propeptide of 20 aa that is removed in the mature form to reveal the GPI anchor. The mature form contains five cadherin domains and eight potential sites for N-linked glycosylation. Mature human Cadherin-13 shares 96% aa identity with mature mouse Cadherin-13. Cadherin-13 is expressed in various tissues. It is highly expressed in the heart, and in the CNS, Cadherin-13 is expressed in the cerebral cortex, medulla, hippocampus, amygdala, thalamus, and substantia nigra (2). There are higher levels of Cadherin-13 in the adult brain than in developing brain (2). Cadherin‑13 is also expressed in skin in the basal layer of the epidermis, lung, liver, kidney, and blood vessels (2). The structural characteristics of Cadherin-13 predict that it is unlikely to function as a true adhesion molecule in vivo (2). It is suggested that it may act rather as a signaling receptor participating in recognition of the environment and regulation of cell motility, proliferation, and phenotype (2). Cellular expression levels of Cadherin‑13 in various tissues often correlate, negatively or positively, with the proliferative potential of the cells (2). Cadherin-13 may also act as a suppressor of tumor cell growth (2). This potential role for Cadherin‑13 was emphasized by localization of Cadherin-13 gene to chromosome 16q24, a region exhibiting loss of heterozygosity in many solid tumors (2). Allelic loss of chromosome bands 16q24.1-q24.2 and reduced expression of Cadherin‑13, as well as hypermethylation of the remaining allele have been detected in a considerable number of human cancers (2).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 5 applications: ICC, IHC, IHC-Fr, Immunoprecipitation, Western Blot.

Showing Publications 1 - 10 of 18. Show All 18 Publications. Collapse Publications.

Publications using AF3264	Applications	Species
Keita Fukuoka, Ryohei Mineo, Shunbun Kita, Shiro Fukuda, Tomonori Okita, Emi Kawada-Horitani et al. ER stress decreases exosome production through adiponectin/T-cadherin-dependent and -independent pathways Journal of Biological Chemistry 9/1/2023 [PMID: 37524131]
Tomonori Okita, Shunbun Kita, Shiro Fukuda, Keita Fukuoka, Emi Kawada-Horitani, Masahito Iioka et al. Soluble T-cadherin promotes pancreatic beta -cell proliferation by upregulating Notch signaling iScience 11/18/2022 [PMID: 36439986]
MR Vitale, JEM Zöller, C Jansch, A Janz, F Edenhofer, E Klopocki, D van den Ho, T Vanmierlo, O Rivero, N Nadif Kasr, GC Ziegler, KP Lesch Generation of induced pluripotent stem cell (iPSC) lines carrying a heterozygous (UKWMPi002-A-1) and null mutant knockout (UKWMPi002-A-2) of Cadherin 13 associated with neurodevelopmental disorders using CRISPR/Cas9 Stem Cell Research, 2021-01-11;51(0):102169. 2021-01-11 [PMID: 33486346] (ICC, Western Blot, Human)	ICC, Western Blot	Human
Y Nakamura, S Kita, Y Tanaka, S Fukuda, Y Obata, T Okita, H Nishida, Y Takahashi, Y Kawachi, Y Tsugawa-Sh, Y Fujishima, H Nishizawa, Y Takakura, S Miyagawa, Y Sawa, N Maeda, I Shimomura Adiponectin Stimulates Exosome Release to Enhance Mesenchymal Stem-Cell-Driven Therapy of Heart Failure in Mice Mol. Ther., 2020-07-10;0(0):. 2020-07-10 [PMID: 32652045] (Western Blot, Human)	Western Blot	Human
Shunbun Kita, Shiro Fukuda, Norikazu Maeda, Iichiro Shimomura Native adiponectin in serum binds to mammalian cells expressing T-cadherin, but not AdipoRs or calreticulin eLife 10/24/2019 [PMID: 31647413]
Stanislaw A. Buechner, Therese J. Resink T-Cadherin Expression in Actinic Keratosis Transforming to Invasive Squamous Cell Carcinoma Dermatopathology (Basel) 1/10/2019 [PMID: 31049318]
D Mori, S Miyagawa, R Matsuura, N Sougawa, S Fukushima, T Ueno, K Toda, T Kuratani, K Tomita, N Maeda, I Shimomura, Y Sawa Pioglitazone strengthen therapeutic effect of adipose-derived regenerative cells against ischemic cardiomyopathy through enhanced expression of adiponectin and modulation of macrophage phenotype Cardiovasc Diabetol, 2019-03-22;18(1):39. 2019-03-22 [PMID: 30902059] (Western Blot, Rat)	Western Blot	Rat
Y Obata, S Kita, Y Koyama, S Fukuda, H Takeda, M Takahashi, Y Fujishima, H Nagao, S Masuda, Y Tanaka, Y Nakamura, H Nishizawa, T Funahashi, B Ranscht, Y Izumi, T Bamba, E Fukusaki, R Hanayama, S Shimada, N Maeda, I Shimomura Adiponectin/T-cadherin system enhances exosome biogenesis and decreases cellular ceramides by exosomal release JCI Insight, 2018-04-19;3(8):. 2018-04-19 [PMID: 29669945] (ICC, Western Blot, Mouse)	ICC, Western Blot	Mouse
Andrea Forero, Olga Rivero, Sina Wäldchen, Hsing-Ping Ku, Dominik P. Kiser, Yvonne Gärtner et al. Cadherin-13 Deficiency Increases Dorsal Raphe 5-HT Neuron Density and Prefrontal Cortex Innervation in the Mouse Brain Frontiers in Cellular Neuroscience 9/26/2017 [PMID: 29018333]
A Frismantie, E Kyriakakis, B Dasen, P Erne, TJ Resink, M Philippova Actin cytoskeleton regulates functional anchorage-migration switch during T-cadherin-induced phenotype modulation of vascular smooth muscle cells Cell Adh Migr, 2017-05-25;0(0):1-17. 2017-05-25 [PMID: 28524745] (Western Blot, Human)	Western Blot	Human
S Fukuda, S Kita, Y Obata, Y Fujishima, H Nagao, S Masuda, Y Tanaka, H Nishizawa, T Funahashi, J Takagi, N Maeda, I Shimomura The unique prodomain of T-cadherin plays a key role in adiponectin binding with the essential extracellular cadherin repeats 1 and 2 J. Biol. Chem, 2017-03-21;0(0):. 2017-03-21 [PMID: 28325833] (Western Blot, Mouse)	Western Blot	Mouse
Georgia M Alexander Vagal Nerve Stimulation Modifies Neuronal Activity and the Proteome of Excitatory Synapses of Amygdala/Piriform Cortex J. Neurochem, 2017-02-03;0(0):. 2017-02-03 [PMID: 27973753] (Western Blot, Rat)	Western Blot	Rat
Stanislaw Buechner T-Cadherin Expression in the Epidermis and Adnexal Structures of Normal Skin Dermatopathology (Basel), 2016-10-21;3(4):68-78. 2016-10-21 [PMID: 27904857] (IHC, Human)	IHC	Human
Cremaschi P, Oliverio M, Leva V et al. Chronic Replication Problems Impact Cell Morphology and Adhesion of DNA Ligase I Defective Cells PLoS ONE. 7/8/2015 [PMID: 26151554] Details: Cadherin-4/R-Cadherin antibody was used at 1:300 dilution for WB assay on lysates from Human SV40-transformed 46BR.1G1 fibroblasts, 7A3 cells and 31W cells (Figure 5 and 6).
Thegna Mavroconstanti, Stefan Johansson, Ingeborg Winge, Per M. Knappskog, Jan Haavik Functional Properties of Rare Missense Variants of Human CDH13 Found in Adult Attention Deficit/Hyperactivity Disorder (ADHD) Patients PLoS ONE 8/1/2013 [PMID: 23936508]
Parker-Duffen , Jennifer, Nakamura , Kazuto, Silver , Marcy, Kikuchi , Ryosuke, Tigges , Ulrich, Yoshida , Sumiko, Denzel , Martin S, Ranscht , Barbara, Walsh , Kenneth T-cadherin is essential for adiponectin-mediated revascularization. J Biol Chem, 2013-07-03;288(34):24886-97. 2013-07-03 [PMID: 23824191] (IHC-Fr, Immunoprecipitation, Western Blot, Mouse)	IHC-Fr, Immunoprecipitation, Western Blot	Mouse
Kyriakakis E, Maslova K, Frachet A, Ferri N, Contini A, Pfaff D, Erne P, Resink T, Philippova M Cross-talk between EGFR and T-cadherin: EGFR activation promotes T-cadherin localization to intercellular contacts. Cell Signal, 2013-02-11;25(5):1044-53. 2013-02-11 [PMID: 23411345] (ICC, Western Blot, Human)	ICC, Western Blot	Human
Philippova M, Ivanov D, Joshi MB, Kyriakakis E, Rupp K, Afonyushkin T, Bochkov V, Erne P, Resink TJ Identification of proteins associating with glycosylphosphatidylinositol- anchored T-cadherin on the surface of vascular endothelial cells: role for Grp78/BiP in T-cadherin-dependent cell survival. Mol. Cell. Biol., 2008-04-14;28(12):4004-17. 2008-04-14 [PMID: 18411300] (ICC, Western Blot, Human)	ICC, Western Blot	Human
Show All 18 Publications. Collapse Publications.

Array AF3264

• Cadherin-13 Antibodies
• Cadherin-13 ELISA Kits
• Cadherin-13 Lysate
• Cadherin-13 Protein
• Cadherin-13 Proteins and Enzymes