C1qTNF1/CTRP1 Antibody (395520) [Unconjugated] Summary
Immunogen |
Mouse myeloma cell line NS0-derived human CTRP1/C1qTNF1 Arg26-Pro281 Accession # Q9BXJ1 |
Specificity |
Detects human CTRP1/C1qTNF1 in direct ELISAs. |
Source |
N/A |
Isotype |
IgG2b |
Clonality |
Monoclonal |
Host |
Mouse |
Purity Statement |
Protein A or G purified from hybridoma culture supernatant |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Immunohistochemistry 1-25 ug/mL
- Western Blot 2 ug/mL
|
Packaging, Storage & Formulations
Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. - 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
|
Buffer |
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. |
Reconstitution Instructions |
Reconstitute at 0.5 mg/mL in sterile PBS. |
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for C1qTNF1/CTRP1 Antibody (395520) [Unconjugated]
Background
C1qTNF1 (CTRP1) is an approximately 35 kDa member of the C1q family of secreted proteins and plays a role in energy metabolism and inflammation (1, 2). C1qTNF1 contains a collagen-like region and one C1q-like domain (3). Mature human C1qTNF1 shares 80% aa sequence identity with mouse and rat C1qTNF1. Circulating levels of C1qTNF1 are elevated in obesity, hypertension, and diabetes but can be decreased in the serum of diet-induced obese mice (4-6). C1qTNF1 expression is up-regulated in atherosclerotic plaques or adipose tissue by oxidized LDL or inflammatory cytokines (3, 7, 8). In turn, it induces the expression of inflammatory cytokines (7, 9) and the up-reglation of adhesion proteins on vascular endothelial cells (8). Systemically administered C1qTNF1, in contrast, can limit tissue damage following myocardial infarction (9). In skeletal muscle, C1qTNF1 promotes fatty acid oxidation, energy expenditure, insulin sensitivity, and glucose uptake and glycolysis (6, 10). It also induces the proliferation of immature chondrocytes (11) and aldosterone synthesis in the adrenal cortex (4). R&D Systems in-house testing indicates that C1qTNF1 binds to BAI3, consistent with the reported interactions between BAI3 and C1qL proteins (12).
- Grebrehiwet, B. et al. (2012) Front. Immunol. 5:3.
- Seldin, M.M. et al. (2014) Rev. Endocr. Metab. Disord. 15:111.
- Kim, K.-Y. et al. (2006) FEBS Lett. 580:3953.
- Jeon, J.H. et al. (2008) FASEB J. 22:1502.
- Xin, Y. et al. (2014) Endocr. J. 61:841.
- Peterson, J. M. et al. (2012) J. Biol. Chem. 287:1576.
- Wang, X.Q. et al. (2016) Atherosclerosis 250:38.
- Lu, L. et al. (2016) Eur. Heart J. 37:1762.
- Yuasa, D. et al. (2016) FASEB J. 30:1065.
- Han, S. et al. (2016) J. Nutr. Biochem. 27:43.
- Akiyama, H. et al. (2013) Mol. Cell. Endocrinol. 369:63.
- Bolliger, M.F. et al. (2011) Proc. Natl. Acad. Sci. USA 108:2534.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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