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BCMA/TNFRSF17 Antibody [Biotin]

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U266 cells were stained with Goat Anti-Human BCMA/TNFRSF17 Biotinylated Antigen Affinity-purified Polyclonal Antibody (Catalog # BAF193, filled histogram) or isotype control antibody (Catalog # BAF108, open histogram) followed by Streptavidin-Phycoerythrin (Catalog # F0040). View our protocol for Staining Membrane-associated Proteins.
U266 cells were stained with Goat Anti-Human BCMA/TNFRSF17 Biotinylated Antigen Affinity-purified Polyclonal Antibody (Catalog # BAF193, filled histogram) or isotype control antibody (Catalog # BAF108, open ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, ELISA(Det)
Clonality
Polyclonal
Host
Goat
Conjugate
Biotin
Concentration
LYOPH

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Allophycocyanin
FAB193A
Fluorescein
FAB193F
Phycoerythrin
FAB193P
Unconjugated
AF193
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
AF193
Carrier Free
AF193
Carrier Free
FAB193A
Carrier Free
FAB193F
Carrier Free
FAB193P
Carrier Free
AF193-SP
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BCMA/TNFRSF17 Antibody [Biotin] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human BCMA/TNFRSF17
Met1-Ala54
Accession # Q6PE46
Specificity
Detects human BCMA in ELISAs and Western blots. In sandwich ELISAs, less than 0.1% cross-reactivity with recombinant human (rh) APRIL, rhBAFF, rhTACI, and recombinant mouse BCMA is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
TNFRSF17
Purity Statement
Antigen Affinity-purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • ELISA Capture (Matched Antibody Pair) 0.2-0.8 ug/mL
  • ELISA Detection (Matched Antibody Pair) 0.1-0.4 ug/mL
  • ELISA Standard (Matched Pair)
  • ELISA Standard (Matched Pair)
  • Flow Cytometry 0.25 ug/10^6 cells
  • Western Blot 0.1 ug/mL
Application Notes
ELISA Capture: Human BCMA/TNFRSF17 Antibody (Catalog # AF193)
ELISA Detection: Human BCMA/TNFRSF17 Biotinylated Antibody (Catalog # BAF193)
Standard: Recombinant Human BCMA/TNFRSF17 Fc Chimera (Catalog # 193-BC)
Readout System
Publications
Read Publications using
BAF193 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for BCMA/TNFRSF17 Antibody [Biotin]

  • B cell maturation antigen
  • B-cell maturation protein
  • BCMA
  • BCMAtumor necrosis factor receptor superfamily member 17
  • BCMB-cell maturation factor
  • CD269 antigen
  • CD269
  • TNFRSF13A
  • TNFRSF17
  • tumor necrosis factor receptor superfamily, member 17

Background

BCMA, B cell maturation, is a member of the TNF receptor superfamily. It has been designated TNFRSF17. BCMA is a type III membrane protein containing one extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of the TNF ligand superfamily. BCMA expression has been found in immune organs and mature B cell lines. Although some expression has been observed at the cell surface, BCMA appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells. This data suggests that BCMA may play an important role in B cell development, function and regulation. Human BCMA is a 184 amino acid (aa) protein consisting of a 54 aa extracellular domain, a 23 aa transmembrane domain, and a 107 aa intracellular domain. Mouse and human BCMA share 62% amino acid identity.

  1. Madry, C. et al. (1998) Int. Immunol. 10:1693.
  2. Gras, M. et al. (1995) Int. Immunol. 7:1093.
  3. Kwon, B. et al. (1999) Curr. Opin. Immunol. 11:340.
  4. Marsters, S. et al. (2000) Curr. Biol. 10:785.
  5. Thompson, J. et al. (2000) J. Exp. Med. 192:129.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for BCMA/TNFRSF17 Antibody (BAF193)(5)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Flow Cytometry.


Filter By Application
Flow Cytometry
(5)
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Human
(5)
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Showing Publications 1 - 5 of 5.
Publications using BAF193 Applications Species
Carpenter , Robert O, Evbuomwan , Moses O, Pittaluga , Stefania, Rose , Jeremy J, Raffeld , Mark, Yang , Shicheng, Gress , Ronald E, Hakim , Frances, Kochenderfer , James N B-cell Maturation Antigen is a Promising Target for Adoptive T-cell Therapy of Multiple Myeloma. Clin Cancer Res, 2013-01-23;19(0):2048-60. 2013-01-23 [PMID: 23344265] (Flow Cytometry, Human) Flow Cytometry Human
Luster , Troy A, Mukherjee , Ipsita, Carrell , Jeffrey, Cho , Yun Hee, Gill , Jeffrey, Kelly , Lizbeth, Garcia , Andy, Ward , Christop, Oh , Luke, Ullrich , Stephen, Migone , Thi-Sau, Humphreys , Robin Fusion Toxin BLyS-Gelonin Inhibits Growth of Malignant Human B Cell Lines In Vitro and In Vivo. PLoS ONE, 2012-10-09;7(10):e47361. 2012-10-09 [PMID: 23056634] (Flow Cytometry, Human) Flow Cytometry Human
Ettinger R, Sims GP, Robbins R, Withers D, Fischer RT, Grammer AC, Kuchen S, Lipsky PE IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cells. J. Immunol., 2007-03-01;178(5):2872-82. 2007-03-01 [PMID: 17312131] (Flow Cytometry, Human) Flow Cytometry Human
Elsawa SF, Novak AJ, Grote DM, Ziesmer SC, Witzig TE, Kyle RA, Dillon SR, Harder B, Gross JA, Ansell SM B-lymphocyte stimulator (BLyS) stimulates immunoglobulin production and malignant B-cell growth in Waldenstrom macroglobulinemia. Blood, 2005-11-22;107(7):2882-8. 2005-11-22 [PMID: 16304043] (Flow Cytometry, Human) Flow Cytometry Human
Moir S, Malaspina A, Pickeral OK, Donoghue ET, Vasquez J, Miller NJ, Krishnan SR, Planta MA, Turney JF, Justement JS, Kottilil S, Dybul M, Mican JM, Kovacs C, Chun TW, Birse CE, Fauci AS Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamily. J. Exp. Med., 2004-10-04;200(7):587-99. 2004-10-04 [PMID: 15508184] (Flow Cytometry, Human) Flow Cytometry Human

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Bioinformatics

Gene Symbol TNFRSF17
Uniprot