ATG16L1 Antibody - BSA Free

Atg16L1 (autophagy-related protein 16-1) forms a component of a protein complex that directs LC3 to autophagosomes en route to their fusion with lysosomes, thereby playing a key role in the process of autophagosome maturation. Atg16L1 belongs to WD repeat ATG16 family, exist as homooligomer and interacts with ATG5 as well as RAB33B, and forms a part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kD) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kD). It is found in cytoplasm and gets localized to preautophagosomal structure where it is implicated in the membrane targeting of ATG5. Mice deficient in Atg16L1 (Atg16L1HM) display reduced autophagy and develop, on viral infection, intestinal abnormalities similar to pathologies found in Crohn's disease patients, including abnormalities in the integrity, architecture, and function of Paneth cells, which are specialized secretory epithelial cells of the small intestine. Atg16L1 has also been shown to play a role in modulating proinflammatory responses and population genetic studies have positively linked a common polymorphism in ATG16L1 gene with inflammatory bowel disease type 10 (IBD10).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 1 application: WB.

Showing Publications 1 - 3 of 3.

Publications using NB110-82384	Applications	Species
Jeong S, Kim Y, Park S et al. Lactobacillus plantarum Metabolites Elicit Anticancer Effects by Inhibiting Autophagy-Related Responses Molecules (Basel, Switzerland) 2023-02-16 [PMID: 36838877] (WB, Human)	WB	Human
Parry H, Randall R, Hyatt H et al. Short and long-term effect of reproduction on mitochondrial dynamics and autophagy in rats Heliyon 2021-09-01 [PMID: 34622072] (WB, Rat)	WB	Rat
Kim YH, Kwak MS, Shin JM et al. Inflachromene inhibits autophagy through modulation of Beclin 1 activity. J Cell Sci 2018-02-20 [PMID: 29361549]

Array NB110-82384

• ATG16L1 Antibodies
• ATG16L1 ELISA Kits
• ATG16L1 Lysate
• ATG16L1 Proteins