Arginase 1/ARG1/liver Arginase Antibody [Alexa Fluor® 700] Summary
Immunogen |
E. coli-derived recombinant human Arginase 1/ARG1 Accession # P05089 |
Specificity |
Detects human, mouse, and rat Arginase 1/ARG1 in direct ELISAs and Western blots. |
Source |
N/A |
Isotype |
IgG |
Clonality |
Polyclonal |
Host |
Sheep |
Purity Statement |
Antigen Affinity-purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Intracellular Staining by Flow Cytometry 0.25-1 ug/10^6 cells
|
Packaging, Storage & Formulations
Storage |
Protect from light. Do not freeze.- 12 months from date of receipt, 2 to 8 °C as supplied.
|
Buffer |
Supplied in a saline solution containing BSA and Sodium Azide. |
Notes
This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Arginase 1/ARG1/liver Arginase Antibody [Alexa Fluor® 700]
Background
Arginase 1 (ARG1) is a 35‑40 kDa member of the arginase family of
enzymes. It is expressed in multiple cell types, including erythrocytes,
hepatocytes, neutrophils, smooth muscle and macrophages. ARG1
demonstrates two distinct functions: in the hepatocyte cytoplasm, it
catalyzes the conversion of arginine to ornithine and urea, while in
multiple cells, it degrades arginine, thus indirectly downregulating NO
synthase (NOS) activity by depriving this enzyme of its substrate. Human
AGR1 is 322 amino acids (aa) in length. Its enzyme region comprises
aa 9‑309 and contains two Mn atoms. ARG1 is modestly active as a
monomer, but highly active as a 105 kDa homotrimer. Trimerization is
promoted by nitrosylation of Cys303, creating a regulatory feedback loop
with NOS. There are two isoform variants, one that shows an eight aa
insertion after Gln43, and another that shows a deletion of aa 204‑289.
Full-length human ARG1 shares 87% aa identity with mouse and rat ARG1.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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