n-Myc Antibody (NMYC-1) - BSA Free

n-Myc, also known as bHLHe37, NMYC, N-myc proto-oncogene protein, and MYCN, is a transcriptional regulator of cell proliferation, differentiation and apoptosis. n-Myc is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Defects in n-Myc are the cause of Feingold syndrome type 1 (FGLDS1), a syndrome characterized by variable combinations of esophageal and duodenal atresias, microcephaly, learning disability, mental retardation, and limb malformations. n-Myc expression is highest during embryonic development and then later in the adult during B-cell development. These expression patterns and results from targeted deletion of n-Myc suggest that n-Myc plays an important role in tissue development and differentiation. Recent research has linked n-Myc to suppressing the anti-apoptotic protein Bcl-2 (PMID: 22920753), as well as elucidated this proteins role in various forms of tumorigenesis (PMID: 22722710).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: Chemotaxis, FLOW, PLA, WB.

Showing Publications 1 - 6 of 6.

Publications using NB200-109	Applications	Species
Ton AT, Foo J, Singh K et al. Development of VPC-70619, a Small-Molecule N-Myc Inhibitor as a Potential Therapy for Neuroendocrine Prostate Cancer International journal of molecular sciences 2022-02-26 [PMID: 35269731] (PLA, Human)	PLA	Human
Gupta R, Turati V, Brian D et Al. Nov/CCN3 Enhances Cord Blood Engraftment by Rapidly Recruiting Latent Human Stem Cell Activity Cell Stem Cell. [PMID: 32197066] (FLOW, Human)	FLOW	Human
Yang Y, Ding L, Zhou Q et al. Silencing of AURKA augments the antitumor efficacy of the AURKA inhibitor MLN8237 on neuroblastoma cells Cancer Cell Int. 2020-01-07 [PMID: 31920463] (WB, Mouse)	WB	Mouse
Murakami-Tonami Y, Ikeda H, Yamagishi R et al. SGO1 is involved in the DNA damage response in MYCN-amplified neuroblastoma cells. Sci Rep. 2016-08-19 [PMID: 27539729] (WB, FLOW, Chemotaxis, Human)	WB, FLOW, Chemotaxis	Human
Murakami-Tonami Y, Kishida S, Takeuchi I et al. Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells. Cell Cycle 2014-01-01 [PMID: 24553121]
Tasseva G, Cole L, Vance JE. N-Myc and SP regulate phosphatidylserine synthase-1 expression in brain and glial cells. J Biol Chem 286(2):1061-73. 2011-01-14 [PMID: 21068393]

Array NB200-109

• n-Myc Antibodies
• n-Myc Lysate
• n-Myc Proteins