MD-2 Products

Description

The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. Toll-like receptor 4 (TLR4), the principal signaling receptor for lipopolysaccharide (LPS) in mammals, requires the binding of MD-2 to its extracellular domain for maximal responsiveness. MD-2 enables TLR4 to respond to a wide variety of LPS partial structures, Gram-negative bacteria, and Gram-positive lipoteichoic acid, but not to Gram-positive bacteria, peptidoglycan, and lipopeptide.

Bioinformatics

Entrez	17087 Mouse 23643 Human 448830 Rat
Uniprot	AAH20690 Human NM_015364 Human NP_056179 Human Q9Y6Y9 Human
Product By Gene ID	23643
Alternate Names	ESOP1 ESOP-1 ly-96 Ly-96 lymphocyte antigen 96 MD2 MD-2 myeloid differentiation protein-2 Protein MD-2

Research Areas for MD-2

Find related products by research area and learn more about each of the different research areas below.

Signal Transduction