GRK3 Products

Description

Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonistmediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first are the second essenger-regulated kinases such as c-AMP dependent protein kinase A and protein kinase C. The second are the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase, GRK 1; two forms of beta-adrenergic receptor kinase, GRK 2 (betaARK, betaARK1) and GRK 3 (betaARK2); IT-11 (GRK 4); GRK 5, GRK 6 and GRK 7.

Bioinformatics

Entrez	157 Human 25372 Rat 320129 Mouse
Uniprot	AAH36797 Human NP_005151 Human P35626 Human
Product By Gene ID	157
Alternate Names	adrenergic, beta, receptor kinase 2 BARK2beta-adrenergic receptor kinase 2 beta-ARK-2 EC 2.7.11 EC 2.7.11.15 G-protein-coupled receptor kinase 3 GRK3Beta-ARK-2

Research Areas for GRK3

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Protein Kinase

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