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Von Willebrand Disease: Disease Bioinformatics

Von Willebrand Disease is a genetic bleeding disorder. The disease occurs when a blood clotting protein, called the von Willebrand Factor, is defected or absent from an individual. This means that individuals with von Willebrand Disease take longer to stop bleeding and form blood clots. The intensity of symptoms vary between individuals, though the most common symptom of von Willebrand Disease is abnormal bleeding. Other common symptoms include frequent nosebleeds, bleeding from gums, easy bruising, and excessive or uncontrolled bleeding. Von Willebrand Disease often has an autosomal dominant inheritance pattern, but the more severe forms are autosomal recessive. Most individuals with von Willebrand Disease have mild symptoms, so diagnosis of the disease can be difficult. Doctors often take blood tests measuring the levels of von Willebrand factor and the ability of the protein to clot. A variety of treatment options are available depending on the severity of the disease in each individual.

Top Research Reagents

We have 4159 products for the study of Von Willebrand Disease that can be applied to Chromatin Immunoprecipitation (ChIP), Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

C-Reactive Protein/CRP [HRP]

DCRP00B

N/A C-Reactive Protein/CRP [HRP]

N/A C-Reactive Protein/CRP [HRP]

Species Human
Applications ELISA

144 Publications

Factor VIII Antibody - BSA Free

NB100-91761

Western Blot: Factor VIII Antibody [NB100-91761] - Detection of Factor VIII protein in extracts from human umbilical vein endothelial cells (HUVECs).

Immunocytochemistry/Immunofluorescence: Factor VIII Antibody [NB100-91761] - Factor VIII antibody was tested 1:50 in HeLa cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). Image objective 40X.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ELISA, ICC/IF

4 Publications

Coagulation Factor II/Thrombin Antibody

NBP1-58268

Western Blot: Coagulation Factor II/Thrombin Antibody [NBP1-58268] - 721_B tissue lysate at a concentration of 1ug/ml.

Immunohistochemistry: Coagulation Factor II/Thrombin Antibody [NBP1-58268] - Analysis of human liver after heat-induced Antigen retrieval. Antibody concentration 5 ug/ml.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, IHC, IHC-P

1 Review

3 Publications

RNF130 Antibody

NBP1-81858

Western Blot: RNF130 Antibody [NBP1-81858] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-478

Immunohistochemistry-Paraffin: RNF130 Antibody [NBP1-81858] - Staining of human kidney shows strong cytoplasmic positivity in cells in tubules.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

Fibronectin Antibody - BSA Free

NBP1-91258

Western Blot: Fibronectin Antibody - BSA Free [NBP1-91258] - VSOP observed in perivascular-restricted spinal cord lesions with intact BBB. Immunostaining for laminin (brown) shows vascular endothelium and glia limitans of a perivascular lesion, along with infiltrating cells and VSOP (blue). Image collected and cropped by CiteAb from the following publication (https://asn.sagepub.com/lookup/doi/10.1042/AN20120081), licensed under a CC-BY license.

Immunocytochemistry/Immunofluorescence: Fibronectin Antibody - BSA Free [NBP1-91258] - NIH3T3 cells were fixed in 4% paraformaldehyde for 10 minutes and permeabilized in 0.05% Triton X-100 in PBS for 5 minutes. The cells were incubated with anti- NBP1-91258 at 1 ug/ml overnight at 4C and detected with an anti-rabbit Dylight 488 (Green) at a 1:1000 dilution for 60 minutes. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 100X objective and digitally deconvolved.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, ICC/IF

11 Reviews

52 Publications

Plasminogen Antibody

NB600-930

Western Blot: Plasminogen Antibody [NB600-930] - Lane 1: Plasminogen. Lane 2: None. Load: 50 ng per lane. Primary antibody: Plasminogen primary antibody at 1:1,000 overnight at 4C. Secondary antibody: Peroxidase goat secondary antibody at 1:40,000 for 60 min at RT. Blocking: incubated with blocking buffer for 30 min at RT. Predicted/Observed size: 91 kDa, 91 kDa for Plasminogen. Other band(s): None.

Western Blot: Plasminogen Antibody [NB600-930] - Detection of Plasminogen under reducing (R) and non-reducing (NR) conditions. Reduced samples of purified target proteins contained 4% BME and were boiled for 5 minutes. Samples of 1ug of protein per lane were run by SDS-PAGE. Protein was transferred to nitrocellulose and probed with 1:3000 dilution of primary antibody. Detection shown was using Dylight 649 conjugated Donkey anti goat 1 hr RT.

Goat Polyclonal
Species Human, Rat
Applications WB, ELISA

2 Reviews

6 Publications

Hemoglobin alpha Antibody - BSA Free

NB110-41083

Goat Polyclonal
Species Human
Applications WB, ELISA, ICC/IF

12 Publications

Von Willebrand Factor Antibody

NB600-586

Dual RNAscope ISH-IHC: Von Willebrand Factor Antibody [NB600-586] - Formalin-fixed paraffin-embedded tissue sections of human metastatic tonsil were probed for vWF mRNA (ACD RNAScope probe, catalog # 5860461; Fast Red chromogen, ACD catalog # 322500). Adjacent tissue section was processed for immunohistochemistry using rabbit polyclonal (Novus catalog # NB600-586) at 1:500 dilution for 1 hour at room temperature followed by incubation with the anti-rabbit IgG VisUCyte HRP Polymer Antibody (Catalog # VC003) and DAB chromogen (yellow-brown). Tissue was counterstained with hematoxylin (blue).

Immunohistochemistry: Von Willebrand Factor Antibody [NB600-586] - Formalin fixed paraffin embedded human tonsil stained with Factor VIII antibody.

Rabbit Polyclonal
Species Human, Mouse, Canine
Applications ICC/IF, IHC, IHC-Fr

3 Reviews

9 Publications

Thrombomodulin/BDCA-3 Antibody [Unconjugated]

AF3894

Thrombomodulin/BDCA-3 was detected in immersion fixed bEnd.3 mouse endothelioma cell line using Goat Anti-Mouse Thrombomodulin/BDCA-3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3894) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights&#8482; 493-conjugated Anti-Goat IgG Secondary Antibody (green; Catalog # <a class=

Thrombomodulin/BDCA‑3 was detected in immersion fixed paraffin-embedded sections of human kidney tissue using Goat Anti-Mouse Thrombomodulin/BDCA‑3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3894) at 1&nbsp;µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte&#8482; HRP Polymer Antibody (Catalog&nbsp;# <a class=

Goat Polyclonal
Species Mouse
Applications WB, Flow, IHC

14 Publications

CD31/PECAM-1 Antibody [Unconjugated]

AF3628

Western blot shows lysates of bEnd.3 mouse endothelioma cell line. PVDF membrane was probed with 0.5 µg/mL of Goat Anti-Human/Mouse/Rat CD31/PECAM-1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3628) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (<a class=

Mouse splenocytes were stained with Goat Anti-Human/Mouse/Rat CD31/PECAM-1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3628, filled histogram) or control antibody (<a class=

Goat Polyclonal
Species Human, Mouse, Rat
Applications WB, Flow, IHC

6 Reviews

467 Publications

ADAMTS13 [HRP]

DADT130

N/A ADAMTS13 [HRP]

N/A ADAMTS13 [HRP]

Species Human
Applications ELISA

11 Publications

Serpin E1/PAI-1 [HRP]

DSE100

N/A Serpin E1/PAI-1 [HRP]

N/A Serpin E1/PAI-1 [HRP]

Species Human
Applications ELISA

44 Publications

VEGF [HRP]

DVE00

N/A VEGF [HRP]

N/A VEGF [HRP]

Species Human
Applications ELISA

672 Publications

P-Selectin/CD62P

137-PS

Species Human
Applications BA

45 Publications

t-Plasminogen Activator/tPA [HRP]

DTPA00

N/A t-Plasminogen Activator/tPA [HRP]

N/A t-Plasminogen Activator/tPA [HRP]

Species Human
Applications ELISA

7 Publications

Tenascin C Antibody (4C8MS) - BSA Free

NB110-68136

Flow (Intracellular): Tenascin C Antibody (4C8MS) [NB110-68136] - Figure A: Intracellular stain performed on U87MG Cells with Tenascin C (4C8MS) antibody NB110-68136 (blue) and a matched isotype control NBP1-97005 (orange). Cells were fixed with 4% paraformaldehyde, following fixation, cells were permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 1 ug/mL for 30 minutes at room temperature, followed by mouse F(ab)2 IgG (H+L) APC-conjugated secondary antibody [F0101B, R&D Systems].Figure B: U87MG Cells were either untreated (orange) or treated with 3uM Monensin (blue). An intracellular stain was performed with Tenascin C (4C8MS) antibody NB110-68136. Cells were fixed with 4% paraformaldehyde, following fixation, cells were permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 1 ug/mL for 30 minutes at room temperature, followed by mouse F(ab)2 IgG (H+L) APC-conjugated secondary antibody [F0101B, R&D Systems].

Western Blot: Tenascin C Antibody (4C8MS) [NB110-68136] - Regulation of Tenascin C expression and its effect on fibrotic responses. Confluent foreskin fibroblasts were incubated with TGF-beta (10 ng ml-1 or indicated concentrations) or Tenascin C (TNC) for 24 or 72 h or indicated periods. Whole-cell lysates, culture media and RNA were examined by western analysis (upper panels) and qPCR (lower panel). Representative immunoblots or qPCR results (means+/-s.e.m. of triplicate determinations). S, secreted; L, lysates. Image collected and cropped by CiteAb from the following publication (https://www.nature.com/doifinder/10.1038/ncomms11703), licensed under a CC-BY license.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, Flow

2 Reviews

26 Publications

Recombinant Human PRH2 GST (N-Term) Protein

H00005555-P01

SDS-Page: Recombinant Human PRH2 Protein [H00005555-P01] - 12.5% SDS-PAGE Stained with Coomassie Blue.

Species Human
Applications WB, ELISA, PA

Related Genes

Von Willebrand Disease has been researched against:

Related Pathways

Von Willebrand Disease has been linked to:

Related Diseases

Von Willebrand Disease has been studied in relation to diseases such as:

Related PTMs

Von Willebrand Disease has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Von Willebrand Disease is also known as Angiohemophilia, Constitutional Thrombopathy, Pseudohaemophilia, Pseudohemophilia, Pseudohemophilia Type B.

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