Tryptophan hydroxylase 2 Products

Description

Tryptophan hydroxylase (TPH) catalyzes the 5-hydroxylation of tryptophan, which is the first step in the biosynthesis of indoleamines (serotonin and melatonin) (Martinez et al., 2001). In mammals, serotonin biosynthesis occurs predominantly in neurons which originate in the Raphe nuclei of the brain, and melatonin synthesis takes place within the pineal gland. Although TPH catalyzes the same reaction within the Raphe nuclei and the pineal gland, TPH activity is rate-limiting for serotonin but not melatonin biosynthesis. Serotonin functions mainly as a neurotransmitter, whereas melatonin is the principal hormone secreted by the pineal gland. The activity of TPH is enhanced by phosphorylation by cAMP-dependent protein kinase (PKA) and Ca2+/calmodulin kinase II (CaM K II) (Jiang et al., 2000; Johansen et al., 1996). CaM K II phosphorylates Ser260 which lies within the regulatory domain of TPH (Jiang et al., 2000).

Bioinformatics

Entrez	121278 Human 216343 Mouse 317675 Rat
Uniprot	NP_775489.2 Human Q8IWU9 Human
Product By Gene ID	121278
Alternate Names	ADHD7 EC 1.14.16 EC 1.14.16.4 FLJ37295 MGC138872 Neuronal tryptophan hydroxylase NTPHMGC138871 tryptophan 5-hydroxylase 2 Tryptophan 5-monooxygenase 2 tryptophan hydroxylase 2

Research Areas for Tryptophan hydroxylase 2

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Lipid and Metabolism
Phospho-Specific