Stathmin 1 Products

Description

Stathmin (oncoprotein 18, op18) is a ubiquitous cytosolic phosphoprotein with various regulatory functions in cell proliferation, differentiation signaling, and activation (1). In particular, stathmin is involved in the regulation of tubulin dynamics through inhibition of microtubule formation and/or microtubule depolymerization. Stathmin interacts with soulable tubulins (alpha,beta-tubulin) resulting in the formation of T2S complex which sequesters free tubulin, impeding tubulin formation (2). Stathmin activity is regulated through phosphorylation at Ser16, Ser25, Ser38 and Ser63 by various protein kinases (e.g. MAP-kinase, p34cdc2 kinase), weakening stathmin's affinity to tubulin (3). A mutation on stathmin can lead to excess build up of mitotic spindle and with possible consequence of unregulated cell cycles seen in cancer cells (4). Stathmin is also known as the generic member of a protein family which includes neural proteins SCG10, SCLIP and RB3/RB3/RB3. All members in this family exhibits tubulin binding ability.

Bioinformatics

Entrez	16765 Mouse 29332 Rat 3925 Human
Uniprot	AAH14353 Human AAH82228 Human NM_005563.3 Human NM_203399 Human NP_005554 Human NP_005554.1 Human NP_981946 Human P16949 Human
Product By Gene ID	3925
Alternate Names	C1orf215 chromosome 1 open reading frame 215 Lag Leukemia-associated phosphoprotein p18 Metablastin metablastin MGC138869 Oncoprotein 18 Op18 OP18MGC138870 phosphoprotein 19 Phosphoprotein p19 pp17 PP17 pp19 PP19 PR22 prosolin Prosolin Protein Pr22 SMNLAP18FLJ32206 stathmin 1 stathmin 1/oncoprotein 18 stathmin transmembrane protein C1orf215

Research Areas for Stathmin 1

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
CD Markers
Immunology
Microglia Markers
Neuroscience
Phospho-Specific
Signal Transduction