Species: Hu, Mu, Rt
Applications: WB, ICC/IF, KO
Host: Rat Monoclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Monoclonal
Species: Hu, Mu
Applications: WB, IP
Species: Hu, Mu, Rt
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Description
SH2-containing inositol phosphatase 1 (SHIP) is a 145 kDa hemopoietic-specific phosphatase that hydrolyzes phosphatidylinositol-3,4,5-triphosphate to phosphatidylinositol-3, 4-bisphosphate. SHIP has been shown to bind directly a phosphorylated motif, immunoreceptor tyrosine-based inhibition motif (ITIM), present in the cytoplasmic domain of FcgammaRIIB1 (1). Also, results demonstrate that FcgammaRIIB use SHIP1 to inhibit pathways shared by receptor tyrosine kinases and immunoreceptors to trigger cell proliferation and cell activation, respectively (2).
Bioinformatics
| Entrez |
Mouse
Human
Rat
|
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
3635 |
| Alternate Names |
- 145kD
- EC 3.1.3
- hp51CNMGC142142
- Inositol polyphosphate-5-phosphatase of 145 kDa
- inositol polyphosphate-5-phosphatase, 145kDa
- MGC104855
- SHIPMGC142140
|
![Western Blot SHIP Antibody (257812) [Unconjugated]](http://images.novusbio.com/fullsize2/SHIP_MAB2317_Western_Blot_6027.jpg)
![Immunocytochemistry SHIP Antibody (257812) [Unconjugated]](http://images.novusbio.com/fullsize2/SHIP_MAB2317_Immunocytochemistry_9852.jpg)
![Knockout Validated SHIP Antibody (257812) [Unconjugated]](http://images.novusbio.com/fullsize/mab2317_human-mouse-rat-ship-mab-clone-257812-20820241518568.jpg)
![Western Blot SHIP Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/SHIP_AF10117_Western_Blot_23233.jpg)
![Immunoprecipitation SHIP Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af10117_human-mouse-ship-affinity-purified-polyclonal-ab-20820241518565.png)
