OPA1 Products

Description

OPA1 product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Highly expressed in the retina, OPA1 mutations have been associated with a dominantly inherited optic neuropathy, called optic atrophy type 1, resulting in progressive loss of visual acuity. Eight transcript variants encoding different isoforms, resulting from alternative splicing of exon 4 and two novel exons named 4b and 5b, have been reported for this gene.

OPA1 antibodies are used primarily for vision research.

Bioinformatics

Uniprot	NP_056375 Human NP_570844 Human NP_570845 Human NP_570846 Human NP_570847 Human NP_570848 Human NP_570849 Human O60313 Human P58281 Mouse Q2TA68 Rat
Product By Gene ID	4976
Alternate Names	FLJ12460 KIAA0567dynamin-like 120 kDa protein, mitochondrial MGM1 mitochondrial dynamin-like GTPase NPGlargeG NTGmitochondrial dynamin-like 120 kDa protein optic atrophy 1 (autosomal dominant) Optic atrophy protein 1

Research Areas for OPA1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Mitochondrial Fusion Proteins
Neurodegeneration
Neuroscience
Sensory Systems
Vision

Related OPA1 Blog Posts

Check out the latest blog posts on OPA1.

Understanding OPA1 and Mitochondrial Function OPA1 belongs to the Dynamin large GTPase protein family. OPA1 exists as a single-pass membrane protein localized in the mitochondrial inner membrane and also as a soluble form in the mitochondrial intermembrane space. There, it is a key player in fusi...    Read more.

Losing memory: Toxicity from mutant APP and amyloid beta explain the hippocampal neuronal damage in Alzheimer's disease  By Jamshed Arslan Pharm.D.  Alzheimer's disease (AD) is an irreversible brain disorder that destroys memory and thinking skills. The telltale signs of AD brains are extracellular deposits of amy...    Read more.

BNIP3 - a regulator of mitochondrial autophagy and cell death Bcl-2 nineteen-kilodalton interacting protein 3 (BNIP3) is a pro-apoptotic BH3-only protein. BNIP3 localizes to the mitochondrial membrane where it plays a key role in mitochondrial autophagy and cell death pathways. Similar to other Bcl-2 family m...    Read more.

Read more OPA1 related blogs.