Species: Hu, Pm, Pm
Applications: WB, ELISA, Flow, IHC, CyTOF-ready
Host: Mouse Monoclonal
Species: Hu
Applications: WB, ICC/IF
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: PAGE
Species: Hu
Applications: AC
Description
Nck is a ubiquitously expressed adaptor protein consisting of one SH2 and three SH3 Src homology domains. Stimulation by epidermal growth factor (EGF) or platelet-derived growth factor (PDGF) leads to phosphorylation of Nck on tyrosine, serine and threonine residues. Overexpression of Nck resulted in transformation of NIH 3T3 and 3Y1 rat fibroblast (1-2). Additionally, Nck has been shown to associate with BLNK, PLCG1 and VAV1 in a B-cell antigen receptor-dependent fashion and may play a role in linking tyrosine and serine/threonine kinase pathways within the cell (2).
Bioinformatics
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
4690 |
| Alternate Names |
- cytoplasmic protein NCK1
- MGC12668
- NCK adaptor protein 1melanoma NCK protein
- nck-1
- Nck-1
- NCKalpha
- NCKNCK tyrosine kinase
- non-catalytic region of tyrosine kinase
- SH2/SH3 adaptor protein NCK-alpha
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