NANS Products

Description

NANS encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant.

Bioinformatics

Uniprot	NM_018946 Human NP_061819 Human NP_061819.2 Human Q9NR45 Human
Product By Gene ID	54187
Alternate Names	EC 2.5.1.56 EC 2.5.1.57 N-acetylneuraminate synthase N-acetylneuraminate-9-phosphate synthase N-acetylneuraminic acid phosphate synthase N-acetylneuraminic acid synthasesialic acid phosphate synthase SASsialic acid synthase