IKK alpha Products

Description

IKK-alpha (I-Kappa-B kinase-alpha) is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP (1-2). Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. Activation of NFKB by TNF requires phosphorylation of IKK-alpha at threonine 23 and serine 176 by AKT1 and NIK respectively (3). It has been demonstrated that IKK-alpha can accumulate in the nucleus after cytokine exposure (4). In the nucleus IKK-alpha interacts with CREB-binding protein in conjunction with RELA to be recruited to the NF-kappa-B-responsive promoters in order to mediate the cytokine-induced phosphorylation and subsequent acetylation of specific residues in histone H3 (5).

Bioinformatics

Entrez	1147 Human 12675 Mouse 309361 Rat
Uniprot	AF009225 Human NP_001269 Human NP_001269.3 Human O15111 Human
Product By Gene ID	1147
Alternate Names	conserved helix-loop-helix ubiquitous kinaseIKBKA EC 2.7.11 EC 2.7.11.10 I-kappa-B kinase 1 I-kappa-B kinase alpha IkappaB kinase IkBKA IKK1I-kappa-B kinase-alpha IKK-A IKKAIkB kinase alpha subunit IKK-alphainhibitor of nuclear factor kappa-B kinase subunit alpha NFKBIKAIKK-a kinase Nuclear factor NFkappaB inhibitor kinase alpha Nuclear factor NF-kappa-B inhibitor kinase alpha TCF16 TCF-16 Transcription factor 16

Research Areas for IKK alpha

Find related products by research area and learn more about each of the different research areas below.

Cancer
DNA Repair
DNA replication, Transcription, Translation and Splicing
Immunology
Innate Immunity
mTOR Pathway
Phospho-Specific
Protein Kinase
Signal Transduction

Related IKK alpha Blog Posts

Check out the latest blog posts on IKK alpha.

IKK alpha: Roles in Development, B-cell Survival and ESC Differentiation Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK1 alpha) is a serine/threonine kinase that forms a complex with IKK beta and NEMO. It plays an essential role in embryonic skin development. Mice with low levels of IKKa show an increase in ...    Read more.

Regulating Immune Response Pathways with IKK beta IKK beta, also known as IKK2, activates the NFkB complex by phosphorylating the NFkB inhibitor, IkBa. Several transcript variants, some protein-coding and some not, have been found for IKKB. The Nuclear Factor-kappa B (NF-kB) family of transcription f...    Read more.

IKK alpha says "no" to NFk beta The nuclear factor kappa B (NFkB) is a ubiquitous transcription factor essential for the activation of immune and inflammatory responses. NFkB activity is inhibited when it is associated with IkB proteins in the cell cytoplasm. IkB proteins are phosph...    Read more.

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